Clinical trials: Psychotropic Drugs
Cognitively Healthy Subjects Influenced by Psychoactive Drugs
Cognitive Hyper-performance - Effects of Stimulating Substances in Chess-players
Effects of caffeine, methylphenidate, modafinil and placebo on cognitive performance of chess players in chess games and neuropsychiatric standardized tests.
- Trial name
- CHESS (NCT01834547)
- Testing
- Drugs use: methylphenidate, Drug use: modafinil, caffeine
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- K. Lieb
Major Depressive Disorder
Relative Bioavailability (RBA) Study of LY03005 vs Pristiq®
The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in…
- Trial name
- NCT03357796
- Testing
- LY03005, Pristiq
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Major Depressive Disorder (MDD)
Genomics Used to Improve DEpression Decisions
Evaluate the impact of GeneSight Psychotropic on response to psychotropic treatment as judged by the mean change in the 17-item Hamilton Depression (HAM-D17) score from baseline to end of Week 8 of the study.
- Trial name
- GUIDED (NCT02109939)
- Testing
- GeneSight Psychotropic
- Where
- 61 sites in United States
- Volunteers
- 1,398 people
- Sponsor
- Assurex Health Inc.
Mental Disorders, Metabolism Medication Toxicity
Pharmacogenomic Profiling of Pediatric Patients
The purpose of this study is to determine the proportion of children presenting to a pediatric emergency department with an acute mental health/behavioral crisis or clinical drug toxicity who have a "match" or "mismatch" between…
- Conditions
- Mental Disorders, Metabolism Medication Toxicity, Pediatric Disorder
- Trial name
- NCT02770339
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Dementia, Psychiatric Disorders Mood
Genetic Evaluation for Medication Selection (GEMS) Study
Investigators propose to determine whether knowing details about how a person's genes affect the way medicines work in the brain and body will help doctors pick more effective or safer medicine for that person.
- Conditions
- Dementia, Psychiatric Disorders Mood, Behavior Disorders
- Trial name
- GEMS (NCT03736057)
- Testing
- Delayed results of pharmacogenomic results
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Healthy
A Study to Evaluate the Pharmacokinetics of Duloxetine in Chinese Han Healthy Subjects
The primary objective of this study is to evaluate the pharmacokinetics of duloxetine hydrochloride tablets in Chinese Han Healthy Subjects.
- Trial name
- NCT00933452
- Testing
- duloxetine
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
Safety and Efficacy of Cariprazine in Schizophrenia
The objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine relative to placebo for the treatment of acute exacerbation of schizophrenia.
- Trial name
- NCT01104779
- Testing
- Cariprazine
- Where
- 41 sites in United States, Colombia and 2 more
- Volunteers
- 446 people
- Sponsor
- Forest Laboratories
Anxiety, Depression
Medical Utilization in Israel During Second Intifada
In this ecological study we examine the impact of stress from repeated terrorist attacks during the second initifada on medical utilization by the Israeli population.
- Conditions
- Anxiety, Depression, Stress
- Trial name
- NCT00350675
- Sponsor
- Sheba Medical Center
Depression, Anxiety
Retrospective Analysis of Outcomes With a Pharmacogenomic Algorithm
Antidepressants are among the most widely prescribed medications, yet only 35-45% of patients achieve remission following an initial antidepressant trial.
- Trial name
- UHS (NCT01632267)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Assurex Health Inc.
Schizophrenia, Tranquilizing Agents
A Study to Evaluate Treatment Adherence in Schizophrenia With Long Acting Risperidone Microspheres (e-STAR)
This study is a non-interventional web based registry designed to assess demographic, treatment and outcomes data in patients receiving treatment with long-acting injectable risperidone.
- Conditions
- Schizophrenia, Tranquilizing Agents, Mental Disorders, Therapeutic Uses
- Trial name
- NCT00294008
- Testing
- Risperdal Consta
- Volunteers
- 230 people
- Sponsor
- Janssen Korea, Ltd., Korea
Parkinson Disease
DaTSCAN Brain Scintigraphy and Psychotropic Treatments: Influence on Radiotracer Binding
DaTSCAN™ (123I-ioflupnae) tomoscintigraphy assesses the density of dopamine transporters (DATs) on the presynaptic membrane of dopaminergic neurons.
- Trial name
- DAPSYFIX (NCT05683665)
- Testing
- scintigraphy DaTSCAN
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Psychoactive Substance Use Disorder
Psychoactive Drug Uses Among Medical and Pharmacy Students
Drug addiction to psychoactive substances, widely consumed in France, represents a major public health issue. The three main motivations identified for the consumption of psychostimulants would be self-medication, the party…
- Trial name
- PSYCHO'ACT (NCT05115981)
- Where
- France
- Volunteers
- 1,930 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Schizophrenia, Psychotic Disorders
Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder
This is a randomized, single-dose, open-label, parallel-group study. Patients will undergo the screening evaluations to determine eligibility within 28 days prior to study drug administration.
- Conditions
- Schizophrenia, Psychotic Disorders, Mood Disorders, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- NCT05321602
- Testing
- LY03010 156 mg treatment group, deltoid, LY03010 156 mg treatment group, gluteal, LY03010 351 mg treatment group, deltoid
- Where
- 9 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Schizophrenia
Long-term Study of Cariprazine in Patients With Schizophrenia
The objective of this study is to evaluate the long-term safety, tolerability, and pharmacokinetics of cariprazine in patients with schizophrenia.
- Trial name
- NCT01104792
- Testing
- Cariprazine
- Where
- 86 sites in United States, Colombia and 4 more
- Volunteers
- 752 people
- Sponsor
- Forest Laboratories
Psychotropic Drugs, Psychiatric Drugs
Decreasing Harms and Improving Child Health
The investigators are doing this study because they know from research and talking with caregivers that kids can be on a bunch of medications, and it's hard to keep track of what the medications are for and whether or not they…
- Conditions
- Psychotropic Drugs, Psychiatric Drugs, Children, Shared Decision Making
- Trial name
- NCT07392489
- Testing
- AWARE Shared Decision Making Medication Review
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- Glyn Jones-Elwyn
Substance Withdrawal Syndrome
Abuse and Addiction in ICU
Investigators are seeking to determine the impact of recent alcohol, smoking or psychotropic drug use prior to intensive care unit (ICU) admission on incidence of delirium and sedation requirements.
- Trial name
- NCT02951793
- Testing
- AUDIT-C, Smoking history, Prior psychotropic medication use
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Autism Spectrum Disorder
A Study Looking at How Well Children With Autism Spectrum Disorder on Medications Like Having More Protein
Antipsychotic medications are commonly prescribed in children and adults with ASD (Curtin, Jojic \& Bandini, 2014). But weight gain has been known to be one of the less desirable effects of these medications, increasing one's…
- Trial name
- NCT03708614
- Testing
- Controlled energy diet with elevated protein intake
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Depression
Implementation Strategies for Task-Shifting Depression Care Depression Care in Vietnam
The study is a Hybrid Implementation-Effectiveness study that will primarily test the implementation strategies on provider adoption and implementation quality in three Vietnam provinces.
- Trial name
- NCT04491045
- Testing
- Workshop Training on Multicomponent Collaborative Care for Depression, Supervision, Community-Engaged Learning Collaborative
- Where
- 2 sites in Vietnam
- Volunteers
- 1,382 people
- Sponsor
- City University of New York, School of Public Health
Bipolar Disorder I, Bipolar II Disorder
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar Illness
To initiate a low-carbohydrate, high-fat (LCHF) or ketogenic dietary (KD) intervention among a cohort of outpatients with bipolar illness who also have metabolic abnormalities, overweight/obesity, and/or are currently taking…
- Conditions
- Bipolar Disorder I, Bipolar II Disorder, Bipolar I Disorder, Bipolar Disorder
- Trial name
- NCT05705063
- Testing
- LCHF Ketogenic Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Post-traumatic Stress Disorder (PTSD)
Discontinuing Psychotropic Medication Before Psychotherapy for PTSD
Post-traumatic stress disorder (PTSD) is commonly treated with trauma-focused psychotherapy, including prolonged exposure therapy and eye movement desensitization and reprocessing (EMDR).
- Trial name
- NCT07802158
- Volunteers
- 100 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam