Clinical trials: Pterygium
Neovascularization, Macular Degeneration
Ziv-aflibercept in Ocular Disease Requiring Anti-VEGF Injection
Background/aims: Aflibercept is an approved therapy for neovascular macular degeneration (AMD), diabetic macular edema (DME), retinal vein occlusion and other retinal conditions.
- Conditions
- Neovascularization, Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- Zaltrap (NCT02486484)
- Testing
- ziv-aflibercept
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Rafic Hariri University Hospital
Pterygium
The Corneal and Conjunctiva Sensation Before and After Pterygium Surgeries
The purpose of this current study is to examine the sensation of the corneal and conjunctiva sensation before and after pterygium surgeries by Cochet bonnet esthesiometer and to examine epidemiological, clinical and imaging…
- Trial name
- NCT03314389
- Testing
- Cochet bonnet esthesiometer
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome
Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase
To date there are no approved effective therapies for the treatment of cryopyrin-associated periodic syndromes (CAPS) including Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), or Neonatal Onset…
- Conditions
- Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease
- Trial name
- NCT00991146
- Testing
- canakinumab
- Where
- 3 sites in Japan
- Volunteers
- 19 people
- Sponsor
- Novartis Pharmaceuticals
Pterygium of Conjunctiva and Cornea
Vertical Split Conjunctival Autograft in Double-head Pterygia
15 eyes of 15 patients with primary double-headed pterygia that underwent vertical split conjunctival autograft pterygium surgery were retrospectively reviewed. All patients had primary double-headed pterygia.
- Trial name
- NCT03507283
- Testing
- Double head pterygia excision and repair
- Volunteers
- 15 people
- Sponsor
- Benha University
Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome
Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease
This trial will assess the safety, efficacy and tolerability of ACZ885 in patients aged 4 years and younger with cryopyrin associated periodic syndromes (CAPS)
- Conditions
- Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease
- Trial name
- NCT01302860
- Testing
- ACZ885
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 17 people
- Sponsor
- Novartis Pharmaceuticals
Corneal Ulcers, Cataract
The Application of Fibrin Glue (Tissucol Duo Quick) in External Eye Surgeries
The fibrin sealants are prepared from fibrinogen, thrombin, and sometimes factor XIII that have been purified from human plasma. Tissucol Duo Quick (Baxter, Vienna, Austria) is a kind of fibrin sealants with popular use.
- Conditions
- Corneal Ulcers, Cataract, Pterygium, Retinal Detachment
- Trial name
- NCT02138019
- Testing
- Fibrin Glue assisted external eye surgery, Fibrin glue
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Percutaneous Pedicular Screw (PPS) Fixation, Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS TLIF) Surgeries
Comparison of Thoracolumbar Interfascial Plane Block (TLIP-block) and Local Anesthetic (LA) Infiltration in Minimally Invasive Spine Surgery: A Randomized Controlled Trial
The goal of this clinical trial is to compare the effectiveness of the thoracolumbar interfascial plane block (TLIP block) versus local anesthetic (LA) infiltration in managing postoperative pain in minimally invasive surgery…
- Trial name
- NCT06761079
- Testing
- Thoracolumbar interfascial plane block, Local anesthetic infiltration
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Conjunctival Diseases, Pterygium
The Use of Natural Latex Biomembrane in Ocular Surface Reconstruction
The main problem of ocular surface reconstruction is the lack of viable conjunctival tissue. The use of a biocompatible latex biomembrane in ocular surface healing, like post pterygium surgery, could be an alternative therapeutic…
- Trial name
- NCT01250353
- Testing
- pterygium surgery
- Where
- Brazil
- Volunteers
- 127 people
- Sponsor
- University of Sao Paulo
Cryopyrin-Associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome
Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease
This will provided long-term safety and efficacy data for ACZ885 (a fully human anti-interleukin-1β [anti-IL-1β] monoclonal antibody) given as an injection subcutaneously in patients who participated in the CACZ885A2102…
- Conditions
- Cryopyrin-Associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome, Muckle Wells Syndrome, Neonatal Onset Multisystem Inflammatory Disease
- Trial name
- NCT00685373
- Testing
- Canakinumab (ACZ885)
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 166 people
- Sponsor
- Novartis
Pterygium, Pterygium of the Conjunctiva and Cornea
CsA vs MMC for Preventing Pterygium Recurrence
aimed to compare the efficacy and safety of topical cyclosporin A (CsA) versus mitomycin C (MMC) as adjunctive therapies in preventing pterygium recurrence after surgical excision.
- Trial name
- MMC (NCT06944132)
- Testing
- Excision of the pterygium, Post-operative application of CsA, Intra-operative application of MMC
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Pterygium
Efficacy and Safety of Sub-tenon Ranibizumab for Recurrent Pterygia
Ranibizumab, an effective antineovascular drug, will be studied for safety and efficacy in pterygium, a neovascular disorder of the ocular surface.
- Trial name
- NCT01169909
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Turner Syndrome, Pterygium Colli
Mehri Turki Webbed Neck Classification
This study aims to identify all types of congenital neck deformities called " webbed neck ". Through a literature survey, the researcher selected 27 articles describing the surgical treatment of the webbed neck, but without…
- Conditions
- Turner Syndrome, Pterygium Colli, Web Neck, Klippel-Feil Syndrome
- Trial name
- NCT06489392
- Where
- Tunisia
- Volunteers
- 78 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital
Diabetic Foot Ulcer (DFU), Ocular Disorder
Air-Dried Human Amniotic Membrane Terminally Sterilized by Gamma Irradiation for Multidisciplinary Clinical Application
This prospective interventional clinical study aims to evaluate the safety and therapeutic efficacy of air-dried human amniotic membrane (hAM) sterilized using different doses of gamma irradiation for regenerative medical…
- Conditions
- Diabetic Foot Ulcer (DFU), Ocular Disorder, Pterygium
- Trial name
- GAMMA-AM (NCT07466576)
- Testing
- Air-Dried Human Amniotic Membrane (AD-hAM)
- Where
- Libya
- Volunteers
- 2 people
- Sponsor
- Libyan Center for Biotechnology Research
Limbal Stem Cell Deficiency
Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency
The purpose of this study is to determine whether cultivated stem cell transplantation is effective for the treatment of patients wtih corneal stem cell deficiency.
- Trial name
- LECT (NCT00845117)
- Testing
- Cultivated limbal stem cell graft transplantation
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Veerle Van Gerwen
Pterygium, Inflammation
Intralesional Bevacizumab Injection on Primary Pterygium
The purpose of this study is to evaluate that intralesional injection of bevacizumab on primary pterygium can reduce the corneal pterygium area, inflammation, redness and other symptoms.
- Trial name
- bevacizumab (NCT01380678)
- Testing
- Intralesional injection of bevacizumab, Topical antihistamine and vasoconstrictor
- Where
- Thailand
- Volunteers
- 206 people
- Sponsor
- Khon Kaen University