Clinical trials: Public Health System Research
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Pregnancy, Neonatal Mortality
Scalable Public Health Empowerment, Research, and Education Sites (SPHERES)
SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model.
- Conditions
- Pregnancy, Neonatal Mortality, Tuberculosis, Hepatitis B
- Trial name
- SPHERES (NCT07126041)
- Testing
- Prescription for Action (SPHERES Model)
- Where
- 2 sites in Indonesia
- Volunteers
- 1,750,000 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Diabetes Mellitus, Cardiovascular Disease
SPREAD-NET: PRactices Enabling Adapting and Disseminating in the Safety NET
The investigators propose to compare the effectiveness of 3 strategies (low, medium, high intensity) at supporting CHCs' implementation of the ALL Initiative (an intervention shown to reduce patients' cardiovascular disease (CVD)…
- Trial name
- SPREAD-NET (NCT02325531)
- Testing
- Low support, Medium support, High support
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2
Smartphone Application for Type 2 Diabetes
Since diabetes is a chronic disease closely related to unhealthy lifestyle, the improvement and management of living habits are as significant as medical care with regard to the disease.
- Trial name
- NCT03468283
- Testing
- mobile application for diabetes
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kangbuk Samsung Hospital
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 3
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER3 (NCT05587725)
- Where
- Australia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Monash University
Prediabetes, Obesity
Healthy Living Partnership to Prevent Diabetes
The Healthy Living Partnership to Prevent Diabetes (HELP PD) is a 300-participant randomized trial designed to test the effectiveness of a lay-health counselor led community-based diabetes prevention program in reducing blood…
- Trial name
- HELP PD (NCT00631345)
- Testing
- Group-Based Lifestyle Intervention (Phases 1 and 2), Individual Education Program (All Phases), Self-Directed Maintenance (Phase 3)
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Colorectal Neoplasms, Breast Neoplasms
Increasing Breast and Colorectal Cancer Screening in the Community
The goal of the proposed study is to conduct a pilot randomized controlled trial (RCT) of Chi gung, a community-based intervention using peer education and tailored navigation to simultaneously improve colorectal (CRC) and breast…
- Trial name
- NCT07748377
- Testing
- Chi gung: Stay Well, Live Well
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
HCV
National Prisons Hepatitis Education Project: Research Evaluation
The National Prisons Hepatitis Education Program (HepPEd Program) is a national, prison-based hepatitis C health literacy education program for healthcare providers, correctional officers, and people in prison.
- Trial name
- HepPEd (NCT05942937)
- Testing
- Education Intervention (The HepPEd Program)
- Where
- 2 sites in Australia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Program Effectiveness, Program Implementation
Implementation Study With Embedded RCT of a Digital System of Parenting Support Within Government Services in South Africa
ParentText, a WhatsApp-based parenting support programme, is designed as a universal intervention to improve parent-child relationships (module 1) and promote child safety (module 2).
- Conditions
- Program Effectiveness, Program Implementation, Parent Child Relationship, Caregiver Child Relationship
- Trial name
- SWIFT (NCT07814261)
- Testing
- Module 1 - Improve My Relationship with My Teen/Child, Module 2 - Keep My Child/Teen Safe and Healthy
- Where
- South Africa
- Volunteers
- 4,961 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
HIV, Tuberculosis
Sustainable East Africa Research in Community Health
The SEARCH study aims to test evidenced-based innovative community based interventions that lead to the elimination of HIV in rural communities in East Africa using a multi-disease approach.
- Conditions
- HIV, Tuberculosis, Hypertension, Diabetes
- Trial name
- SEARCH (NCT01864603)
- Testing
- Universal ART in a streamlined care model, Annual Community Health Campaigns, Targeted PrEP and Targeted testing interventions
- Where
- 3 sites in Kenya, Uganda
- Volunteers
- 150,395 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Deafness
Assessing the Impact of Vidéo Remote Sign Language Interpreting in Healthcare
This is a randomise study that looks at what is the effectiveness of the VRI system in improving communication outcomes between Deaf patients and doctors versus the 'available standard of care of the usual communication tools…
- Trial name
- Impact of VRI (NCT05966623)
- Testing
- Video Remote Interpretation
- Where
- 2 sites in Colombia
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Public Health, Public Health System Research
Early ECG Prediction of Multi-system Disease Cohort Establishment and Follow Up
This registered multicenter study aims to investigate the diagnostic efficacy of artificial intelligence-enhanced electrocardiography (AI-ECG) in detecting multi-system diseases.
- Conditions
- Public Health, Public Health System Research, Multi-system Disease Diagnosis
- Trial name
- EARLY-ECG-PRED (NCT06924580)
- Testing
- ECG screening
- Where
- China
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Meta-analyses of Impotrant Food Sources of Sugars and Incident Cardiometabolic Diseases
There is an urgent need for stronger evidence to support recommendations for the role of sugars in diabetes and related cardiometabolic diseases.
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome X, Hypertension, Cardiovascular Diseases
- Trial name
- NCT02702375
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Health-Related Quality-of-Life, Social Capital
Cocreating Action to Improve Rationality in the Health System
Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination).
- Conditions
- Health-Related Quality-of-Life, Social Capital, Health Literacy, Community Based Participatory Research
- Trial name
- CAIR (NCT07237971)
- Testing
- Cocreation process
- Where
- 2 sites in Spain
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Acute Pain, Atrophic
Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy
The purpose of this study is to examine deficits in activation and motor patterns, as well as central drive in patients with rotator cuff tendinopathy.
- Conditions
- Acute Pain, Atrophic, Goals, Impairment
- Trial name
- NCT02971072
- Testing
- Subacromial injection, Physical Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Oregon