Clinical trials: Pulmonary Atelectases
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
Atelectasis
Effects of Spontaneous Breathing Activity on Atelectasis Formation During General Anaesthesia
Atelectasis and redistribution of ventilation towards non-dependent lung zones are a common side effects of general anesthesia. Spontaneous breathing activity (SBA) during mechanical ventilation may avoid or reduce atelectasis…
- Trial name
- SBAFGA (NCT01073917)
- Testing
- Spontaneous Breathing, Pressure Controlled Ventilation, Pressure Support Ventilation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Atelectasis
Lung Recruitment Assessment With Lung Ultrasound In Pediatric Patient Scheduled For Laparoscopic Surgery
Anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia.
- Trial name
- NCT02824146
- Testing
- Lung recruitment maneuver
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Atelectasis
Peroperative Use of Positive End-expiratory Pressure Prevents Formation of Atelectasis as Studied by Computerised Tomography at End of Surgery
Atelectasis is common during and after general anaesthesia and a number of interventions have been suggested in order to prevent their formation.
- Trial name
- NCT02548416
- Testing
- Positive end-expiratory pressure, Control group, zero PEEP
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Västmanland
Lung Disorder
Ventilatory Strategy for the Prevention of Atelectasis During Bronchoscopy Under General Anesthesia, VESPA Trial
This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing bronchoscopy under general anesthesia.
- Trial name
- NCT04311723
- Testing
- Anesthesia Procedure, Bronchoscopy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Atelectasis
Perioperative Atelectasis in Orthopaedic Surgery: a Prospective Study
This study aims at comparing a perioperative pulmonary atelectasis score, measured by pulmonary ultrasound, in patients operated undergoing orthopedic surgery under general anesthesia, spinal anesthesia or peripheral nerve block.
- Trial name
- ATELHO (NCT05384795)
- Testing
- Lung ultrasound
- Where
- Switzerland
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Eric Albrecht
Atelectasis, Acquired Brain Injury
Variation of Atelectasis Score After High-frequency Percussions in Severe Acquired Brain Injury
Investigators conduced in the Neurological Rehabilitation Unit of the IRCCS "S.Maria Nascente - Fondazione Don Gnocchi", (Milan) a retrospective study on 19 patients hospitalized between September 2018 and February 2021, with the…
- Conditions
- Atelectasis, Acquired Brain Injury, Respiratory Rehabilitation
- Trial name
- NCT05630079
- Testing
- Treatment with Metaneb®, Treatment with IPV®
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Hypoxia
Efficacy and Safety of Using Noninvasive Ventilation Associated With Recruitment Maneuver in Cardiac Surgery.
Cardiac surgery can evolve with complications in the postoperative period, atelectasis and hypoxemia are the major pulmonary dysfunctions.
- Trial name
- NCT02913391
- Testing
- recruitment group (RG), control group (CG)
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Mieko Cláudia Miura
Postoperative Pulmonary Atelectasis
Diagnostic Values of Lung Ultrasound for Perioperative Atelectasis
Lung ultrasound offers a novel, reliable and radiation-free tool for diagnosing perioperative atelectasis and evaluating its severity in adult patients undergoing general anesthesia in the operating room.
- Trial name
- NCT02355405
- Testing
- lung ultrasound, thoracic computed tomography
- Where
- 2 sites in China
- Volunteers
- 46 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Foetus With Congenital Pulmonary Malformation
Risk Factors of Neonatal Respiratory Distress for Newborns With Prenatally Diagnosed Congenital Lung Malformations
This research focuses on lung malformations detected in fetuses during prenatal ultrasound exams. Pathogenic mechanisms of these rare malformations are poorly understood.
- Trial name
- MALFPULM (NCT02352207)
- Testing
- identification of a pulmonary malformation in the fetus
- Where
- France
- Volunteers
- 436 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Collapse, One-Lung Ventilation
Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung isolation technique and one-lung ventilation (OLV) are the mainstays of thoracic anesthesia. Two principal lung isolation techniques are mainly use by clinicians, the double lumen tubes (DLT) and the bronchial blockers (BB).
- Conditions
- Lung Collapse, One-Lung Ventilation, Thoracic Surgery, Video-Assisted
- Trial name
- PLC-OLV (NCT02919267)
- Testing
- Double lumen tube, Bronchial blocker
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
Atelectasis
Lung Recruitment Improves Right Ventricle Performance
This study test whether a lung recruitment maneuver improves the right ventricle performance after cardiopulmonary bypass. Half of the patients received an standard protective ventilation and the other half the same ventilatory…
- Trial name
- NCT02795208
- Testing
- Lung recruitment maneuver
- Volunteers
- 40 people
- Sponsor
- Hospital Privado de Cordoba, Argentina
Neonatal Respiratory Distress
The Role of ARTificial Uterine CONtractions in Perinatal Respiratory Morbidity of Term Infants Delivered by Elective Caesarean Section
In this study, the investigators aim to investigate if artificial uterine contractions prior to elective caesarean section delivery may have an impact on the respiratory morbidity of term neonates.
- Trial name
- ARTCON (NCT03899597)
- Testing
- Oxytocin, Normal saline
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Cardiac Congenital Defects
Volume Versus Pressure Ventilation on Lung Atelectasis
This prospective randomized comparative study, to assess post-operative lung atelectasis by comparing calculated lung score using ultrasound between pediatric patients intubated with LMA (laryngeal mask airway) under volume…
- Trial name
- NCT06076395
- Testing
- LMA (Laryngeal Mask Airway)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
Carcinoma, Non Small Cell Lung
Validation of Coregistered CT-PET Imaging in Determining Tumor Volume and Atelectasis in Patients With Operable Non-Small-Cell Lung Cancer and Tumor Associated Atelectasis
CT-PET image fusion has the potential to differentiate 'tumor' from 'atelectasis' much better than the CT-scan in patients with non-small cell lung cancer who also have atelectasis.
- Trial name
- NCT00184964
- Testing
- CT-scan, PET-scan
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Respiratory Distress Syndrome, Newborn
Intrapulmonary Percussive Ventilation (IPV) Versus Nasal Continuous Positive Airway Pressure Ventilation (nCPAP) in Transient Respiratory Distress of the Newborn
During caesarean section, transient respiratory distress which occurs frequently (3%) with possible complications are at present managed by non invasive nasal continuous positive airway pressure ventilation (nCPAP) associated…
- Trial name
- HFPV (NCT00556738)
- Testing
- Nasal Continuous Positive Airway Pressure ventilation, Intrapulmonary Percussive Ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity
Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
The goal of this pragmatic clinical trial is to learn if the drug surfactant given by a less invasive technique works to treat respiratory distress in preterm infants in low- and middle-income African countries where invasive…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Premature Birth
- Trial name
- NCT06554522
- Testing
- Surfactant
- Where
- 8 sites in Central African Republic, Ghana and 2 more
- Volunteers
- 1,512 people
- Sponsor
- Indiana University