Clinical trials: Pulmonary Collapse
Immunity, Vaccine Reaction
Efficacy and Tolerability of ABBC1 in Volunteers Receiving the Influenza or Covid-19 Vaccine
The immune system response needs to be forceful but also balanced for a rapid recovery from infection which avoids harmful overreactions.
- Conditions
- Immunity, Vaccine Reaction, Influenza, Covid19
- Trial name
- NCT04798677
- Testing
- ABBC1 Immunoessential
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AB Biotek
Lung Injury, Acute
Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction
Anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. The study aimed to validate that a positive end-expiratory pressure (PEEP) of 10 cmH2O could reduce lung…
- Trial name
- NCT06900426
- Testing
- 10 PEEP, ZEEP, 5PEEP
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
Pediatric Lung Atelectasis
Effectiveness of Ultrasound-guided Lung Ventilation in Determining the Optimum Inspiratory Pressure in Pediatric Patients
This study aimed to show the Effectiveness of Ultrasound-guided Lung Ventilation to determine the appropriate level of inspiratory pressure sufficient to provide adequate pulmonary ventilation with the resolution of the…
- Trial name
- NCT06188169
- Testing
- Increasing the inspiratory pressure if atelectasis detected by US
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cholelithiasis, Epigastric Hernia
Using Pre-op Incentive Spirometer Reduces Chances of Basal Atelectasis in Patients Undergoing Upper Abdominal Surgeries
ABSTRACT Objective: To compare frequency of basal atelectasis in patients undergoing upper abdominal surgery who are provided pre-operative incentive spirometry versus those not provided pre-operative incentive spirometry
- Conditions
- Cholelithiasis, Epigastric Hernia, Duodenal Perforation
- Trial name
- NCT06115941
- Testing
- Pre-Op Incentive Spirometer
- Where
- Pakistan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Dr. Muhammad Naeem
Lung Ultrasound, Atelectasis
Surgical Positions and Postoperative Atelectasis: A Lung Ultrasound Study
The aim of this study is to prospectively evaluate the effect of surgical position on the development of postoperative atelectasis in patients undergoing surgery in supine, prone, lateral decubitus, and lithotomy positions using…
- Trial name
- NCT07654153
- Testing
- lung ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Atelectasis, General Aneshesia
Effects of Anesthesia on Atelectasis
We know that respiratory functions of patients are affected under general anaesthesia. Although there are many underlying causes of ventilation-perfusion mismatch in the airways, the main cause is atelectasis during general…
- Trial name
- NCT06790901
- Testing
- LUNG ULTRASOUND
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Lung Disorder
Ventilatory Strategy for the Prevention of Atelectasis During Bronchoscopy Under General Anesthesia, VESPA Trial
This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing bronchoscopy under general anesthesia.
- Trial name
- NCT04311723
- Testing
- Anesthesia Procedure, Bronchoscopy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Atelectasis, Cesarean Section
Atelectasis by Lung Ultrasonography in Cesarean Sections
In this study aimed to demonstrate that atelectasis developing in the perioperative period of patients undergoing elective cesarean surgery with spinal or general anesthesia methods using lung ultrasound.
- Trial name
- NCT04591327
- Testing
- The Effect of General Anesthesia and Spinal Anesthesia on Postoperative Atelectasis by Lung Ultrasonography in Cesarean Sections
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity, Pulmonary Atelectasis
Effects of PEEP on Heart and Lungs in Obese Subjects
Aim of this study is to better understand pathophysiology of the alteration of respiratory mechanics and cardiovascular function in obese volunteer subjects.
- Conditions
- Obesity, Pulmonary Atelectasis, Obesity Hypoventilation Syndrome, Magnetic Resonance Imaging
- Trial name
- NCT02523352
- Testing
- Non-Invasive Ventilation, Esophageal catheter positioning
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Postoperative Pulmonary Complications
Consensus Statements on Definition, Components and Grading of Postoperative Pulmonary Complications
An international team of experts is working on a project called PrECiSIOn to develop a clear, consistent definition of PPCs. The goals of this study are to: Define postoperative pulmonary complications in a way that makes sense…
- Trial name
- PrECiSIOn (NCT06916598)
- Testing
- Delphi study, Structured Interview
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pulmonary Atelectasis, Respiratory Tract Diseases
Influence of Different Physical Therapy Resources Application After Reduction Stomach Surgery
The aim of this study will be to investigate the effects of using physical therapy resources in the postoperative morbidly obese individuals undergoing gastroplasty.
- Conditions
- Pulmonary Atelectasis, Respiratory Tract Diseases, Pathological Conditions, Signs and Symptoms
- Trial name
- NCT01872663
- Testing
- Continuous positive airway pressure, Incentive spirometry, Breath Stacking
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
COVID-19, Critical Illness
Immune Modulation by Exosomes in COVID-19
Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.
- Conditions
- COVID-19, Critical Illness, Hypercytokinemia, Lung Fibrosis
- Trial name
- IMECOV19 (NCT05191381)
- Testing
- Application of exosomes in a whole blood assay
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Neonatal Respiratory Distress
A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure
The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an alternative to other forms of non-invasive ventilation mechanism to provide continuous distending pressure to preterm infants.
- Trial name
- NCT04051762
- Testing
- High flow nasal cannula vs. Nasal continuous positive airway pressure
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ramy Saleh Morsy
Anesthesia
Evaluation of Atelectasis Formation With Electrical Impedance Tomography During Anesthesia for MRI in Children
This study investigates under controlled conditions the variation of poorly ventilated lung units (silent spaces) in children between 1 and 6 years of age measured by electrical impedance tomography during intravenous anaesthesia…
- Trial name
- ATLANTIS (NCT04507581)
- Testing
- electrical impedance tomography during anaesthesia
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atelectasis, Postoperative Pulmonary
Evaluation of the Effects of Different Ventilation Modes Used During Anesthesia Awakening on the Frequency of Postoperative Atelectasis
In our study, we aimed to detect atelectasis developing in patients undergoing surgery under general anesthesia using transthoracic lung ultrasonography and to investigate the effect of ventilation methods used during recovery…
- Trial name
- NCT06358027
- Testing
- lung ultrasound
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Atelectasis
The Effect of Lung Recruitment Maneuver on Postoperative Atelectasis in Children
The investigators compare the degree of atelectasis in recovery room between conventional recruitment maneuver and ultrasonography-guided lung recruitment during surgery.
- Trial name
- NCT03453762
- Testing
- recruitment maneuver, ultrasonography-guided recruitment maneuver
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital