Clinical trials: Pulmonary Complications
COVID-19
INB03 for the Treatment of Pulmonary Complications From COVID-19
The purpose of this study is to determine whether XPro1595 can prevent the progression of respiratory complications in COVID19 patients.
- Trial name
- NCT04370236
- Testing
- INB03
- Where
- 9 sites in United States
- Volunteers
- 79 people
- Sponsor
- Inmune Bio, Inc.
Complication,Postoperative, Lung Cancer
Relationship Between Hand Dynamometer Measurements, PFT, and mFI With Postoperative Outcomes
The study will take place at SBÜ Ankara Atatürk Sanatorium Training and Research Hospital and will include 100 patients over the age of 40 who are scheduled for lung malignancy surgery after 01 April 2024.
- Trial name
- NCT06338007
- Testing
- Hand Dynamometer, Pulmonary Function Test, Modified Frailty Index
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
VExUS in Ards Patients and Association with AKI
A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score.
- Trial name
- VEXAKI (NCT06805409)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Melanoma, Non Small Cell Lung Cancer
Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors
AI-061 is a co-formulation drug product (DP) consisting of 1:1 ratio mix of AI-025, an anti-PD-1 antibody, and ONC-392, an anti-CTLA-4 antibody.
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, High Grade Serous Adenocarcinoma of Ovary
- Trial name
- PRESERVE-009 (NCT05858736)
- Testing
- AI-061
- Where
- 5 sites in Australia
- Volunteers
- 18 people
- Sponsor
- OncoC4, Inc.
Mechanical Ventilation Complication, Pneumonia
Mechanically Ventilated Children and Pacifiers
Mechanical ventilation is a life support system developed to support or restore normal lung functions. Children who are connected to mechanical ventilator, separation from family in intensive care environment, getting away from…
- Conditions
- Mechanical Ventilation Complication, Pneumonia, Bronchiolitis
- Trial name
- NCT05566184
- Testing
- Modified pacifier
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hitit University
Mechanical Ventilation Complication, Pulmonary Edema
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
- Trial name
- SystoWean (NCT05226247)
- Testing
- Spontaneous breathing trial
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Respiratory Distress Syndrome, Adult, Critical Illness
Measuring Heart and Lung Function in Critical Care
This is a feasibility study of the use of a novel technique called 'Inspiwave' to measure heart and lung function in adult patients in critical care.
- Conditions
- Respiratory Distress Syndrome, Adult, Critical Illness, Mechanical Ventilation Complication, Haemodynamic Instability
- Trial name
- NCT03424798
- Testing
- Inspiwave
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Postoperative Pain, Pulmonary Function Tests
The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery
In adult patients undergoing cardiac surgery, does adding an sPIP block to standard care compared to standard care alone result in a smaller decrease in PFTs?
- Trial name
- PIPACS (NCT05999721)
- Testing
- superficial parasternal intercostal plane block, Standard care
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Shai Fein
Respiratory Distress Syndrome
A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants
The purpose of this study is to see if a medication called Curosurf can reduce the length of time that small premature babies with Respiratory Distress Syndrome (immature lungs) or RDS, stay on the ventilator, as compared to the…
- Trial name
- NCT01709409
- Testing
- Curosurf-Group1, BLES-group 2
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Ottawa Hospital Research Institute
Postoperative Complications, Long-term Outcome
Prophylactic Penehyclidine Hydrochloride Inhalation and 3-year Outcome After Surgery
Postoperative pulmonary complications (PPCs) are major causes of postoperative morbidity, mortality, and prolonged hospital stay.The incidence of PPCs may be as high as 41% to 75% in high-risk patients.
- Trial name
- NCT03868709
- Testing
- Penehyclidine inhalation
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Peking University First Hospital
COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Quality of Life 1y and 2 y After VV-ECMO for COVID-19
This study aims to investigate the quality of life and the outcome after veno-venous extracoporeal membrane oxygenation (ECMO) support fir severe acute respiratory syndrome (ARDS) in COVID-19 patients.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Quality of Life, Death
- Trial name
- NCT05780255
- Testing
- VV-ECMO
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- University Hospital, Ghent
Lung Transplant, Primary Graft Dysfunction
Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants
Proning manoeuvre as an early treatment for acute severe hypoxic respiratory failure has been implemented recently during the COVID-19 pandemic.
- Trial name
- NCT06159933
- Testing
- Supine positioning, Early pronation, Late pronation
- Where
- Italy
- Volunteers
- 67 people
- Sponsor
- University of Padova
Mechanical Ventilation Complication, Respiratory Failure
Effect of PEEP on Lung Regional Ventilation and Perfusion
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
- Conditions
- Mechanical Ventilation Complication, Respiratory Failure, Hypoxia
- Trial name
- PEEP (NCT04081155)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Yun Long
Pneumonia, Blood Stream Infection
Optimizing Clinical Use of Polymyxin B
Polymyxin B is already being used extensively in the USA and other parts of the world; its use is likely to rapidly increase due to the greater burden of infections caused by MDR Gram-negative bacteria and the growing awareness…
- Conditions
- Pneumonia, Blood Stream Infection, Urinary Tract Infections, Respiratory Tract Infection (Including Tracheobronchitis)
- Trial name
- NCT02682355
- Where
- 6 sites in United States, Brazil and 1 more
- Volunteers
- 155 people
- Sponsor
- Rutgers, The State University of New Jersey
Premature Birth, Respiratory Distress Syndrome, Newborn
Non-invasive Neurally Adjusted Ventilator Assist or Continuous Positive Airway Pressure in Preterm Infants
Strategies to prevent lung injury, facilitate lung development, and to support the preterm infant's capacity to breathe are decisive.
- Trial name
- NCT04333563
- Testing
- CPAP, NIV NAVA
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
One Lung Ventilation in Thoracic Surgery
Oxygen Reserve Index Guided FiO₂ Titration in One-Lung Ventilation
One-lung ventilation (OLV) is routinely used during thoracic surgery to facilitate surgical exposure but is associated with an increased risk of intraoperative hypoxemia.
- Trial name
- NCT07359833
- Testing
- Oxygen Reserve Index (ORi)-guided oxygen titration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
COVID-19; Cardiovascular Diseases
Cardiac complicAtions in Patients With SARS Corona vIrus 2 (COVID-19) regisTrY
CAPACITY (www.capacity-covid.eu) is a registry of patients with COVID-19 across Europe and has been established to answer questions on the role of cardiovascular disease in this pandemic.
- Trial name
- CAPACITY-COVID (NCT04325412)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Pulmonary Arterial Hypertension, Erectile Dysfunction
A Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients with Renal Insufficiency and Healthy Subjects
To evaluate the effect of renal insufficiency on the pharmacokinetics of TPN171H tablets after single dose oral administration, so as to provide basis for formulating clinical medication plan for patients with renal…
- Trial name
- NCT05208814
- Testing
- TPN171H single dose
- Where
- 2 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Small Cell Lung Carcinoma, Non Small Cell Lung Carcinoma
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients
The purpose of this study is to determine a well-tolerated dose of Carfilzomib in combination with Irinotecan (Phase 1b portion of the study) in subjects with relapsed small and non-small cell lung cancer or other…
- Conditions
- Small Cell Lung Carcinoma, Non Small Cell Lung Carcinoma, Irinotecan Sensitive Cancers
- Trial name
- NCT01941316
- Testing
- Carfilzomib, Irinotecan
- Where
- 8 sites in United States
- Volunteers
- 78 people
- Sponsor
- Cancer Research and Biostatistics Clinical Trials Consortium
Breast Cancer, Lung Cancer
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma
- Trial name
- OCTANE (NCT02906943)
- Where
- 7 sites in Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
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