Clinical trials: Pulmonary Cystic Fibrosis
Cystic Fibrosis
Bacteriophage Effects on Pseudomonas Aeruginosa
Pulmonary phage therapy to treat bacterial infections of the respiratory tract have been investigated in animals. The aim of the present study is to evaluate the efficacy of bacteriophages in infecting Pseudomonas aeruginosa (PA)…
- Trial name
- MUCOPHAGES (NCT01818206)
- Testing
- Collection of induced sputum in order to evaluate the efficacy of a cocktail of 10 bacteriophages.
- Where
- France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis, Pancreatic Insufficiency
Oral TheraCLEC™ - Total in Cystic Fibrosis Subjects With Exocrine Pancreatic Insufficiency
The purpose of this study is to determine the most effective dose of a new enzyme therapy on oral nutrient absorption in cystic fibrosis (CF) subjects with exocrine pancreatic insufficiency.
- Trial name
- NCT00095732
- Testing
- Liprotamase
- Where
- 27 sites in United States
- Volunteers
- 129 people
- Sponsor
- Anthera Pharmaceuticals
Cystic Fibrosis
Breath Analysis in in Adults With Cystic Fibrosis (CF)
Exploratory comparative evaluation of exhaled breath composition in cystic fibrosis patients with age and gender-matched healthy adults in order to identify a disease-specific exhaled breath pattern as well as to gain insight…
- Trial name
- NCT02209571
- Testing
- Venous blood markers
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cystic Fibrosis
Utility of Induced Sputum Using Hypertonic Saline to Evaluate Infection and Inflammation in Cystic Fibrosis
The objective of the study is to evaluate the clinical utility and the feasibility, in an outpatient setting, of sputum induction using hypertonic saline.
- Trial name
- NCT00721071
- Testing
- Hypertonic Saline
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Do Musculoskeletal Techniques Improve Forced Expiratory Volume in One Second in Adults With Cystic Fibrosis?
The pilot study aims to evaluate the effects of a treatment series of gentle joint and muscle movements (in addition to normal optimal care)on lung function, exercise capacity and posture in stable adults with cystic fibrosis.
- Trial name
- NCT00716664
- Testing
- A treatment series of gentle joint and muscle movements, Control group measurements
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cystic Fibrosis, Siblings
The Development and Evaluation of iCF-PWR for Healthy Siblings of Individuals With Cystic Fibrosis
The goal of the clinical trial is to test whether a mental health program that is delivered through the Internet works well for healthy children and adolescents with siblings with cystic fibrosis (CF).
- Conditions
- Cystic Fibrosis, Siblings, Mental Health, Internet-based Intervention
- Trial name
- NCT06012084
- Testing
- Internet-delivered Cystic Fibrosis Mental Health Prevention, Wellness, and Resource (iCF-PWR) program
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Regina
Cystic Fibrosis
Cystic Fibrosis Blood Neutrophils
The purpose of this prospective study is to analyze function and phenotype of blood neutrophils in cystic fibrosis patients and the impact of Pseudomonas aeruginosa chronic infection, treatment with CFTR modulators and acute…
- Trial name
- MUCO-PNN (NCT04970225)
- Testing
- 1 blood sample, 2 blood samples
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Disease, Cystic Fibrosis
Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease
The primary objective of this study is to determine if quantitative Dynamic contrast-enhanced magnetic resonance (DCE MR) perfusion imaging accurately quantifies right and left pulmonary artery blood flow as compared with phase…
- Conditions
- Heart Disease, Cystic Fibrosis, Asthma
- Trial name
- NCT01192360
- Testing
- Phase contrast flow velocity mapping (PC), Dynamic contrast-enhanced magnetic resonance imaging
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis, Infection, Bacterial
Manuka Honey Sinus Rinse Study
A trial investigating the effect of a sinus rinse in people with CF
- Trial name
- NCT04589897
- Testing
- Manuka honey sinus rinse, Standard sinus rinse
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Swansea University
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cystic Fibrosis, Pulmonary
Real World Environmental Exposure Study With Healthy and Cystic Fibrosis Subjects
Cystic fibrosis (CF) is the most common autosomal recessive disease that leads to early mortality in Caucasians and affects around 7500 patients in France.
- Trial name
- ExpoCF (NCT06339450)
- Testing
- walk tours
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
CF - Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Relationship Between the Development of Impaired Glucose Tolerance, the Phenotype of CFLD, and the Risk of Liver Fibrosis
This study proposes to examine the relationship between the development of impaired glucose tolerance, the phenotype of CFLD, and risk of liver fibrosis.
- Conditions
- CF - Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis Liver Disease
- Trial name
- NCT05229640
- Testing
- Fibroscan
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cystic Fibrosis, Chronic Pancreatitis
Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon
Exocrine pancreatic insufficiency (EPI) is a condition that is caused by the inadequate pancreatic enzymes needed for normal digestion and is commonly associated with a wide range of chronic diseases, including cystic fibrosis…
- Trial name
- NCT05069597
- Testing
- CREON
- Where
- 21 sites in United States
- Volunteers
- 30 people
- Sponsor
- AbbVie
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD)
- Trial name
- NCT04530383
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Cystic Fibrosis
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of single and multiple ascending doses of VX-272 in combination with deutivacaftor (D-IVA) with or without tezacaftor (TEZ) in healthy…
- Trial name
- NCT07437105
- Testing
- VX-272, Tezacaftor, Deutivacaftor
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis
A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis
This is a Phase 2, randomized, double-blind, placebo- and tezacaftor/ivacaftor (TEZ/IVA)-controlled, parallel-group, 3-part, multicenter study designed to evaluate the safety and efficacy of VX-659 in triple combination (TC) with…
- Trial name
- NCT03224351
- Testing
- VX-659, TEZ/IVA, IVA
- Where
- 47 sites in United States, Ireland and 2 more
- Volunteers
- 124 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis
IL-17 Neutrophils in CF Lung Inflammation
The purpose of this study is to determine whether IL-17 polymorphonuclear leukocytes (PMNs) are central to the disease pathology in CF.
- Trial name
- NCT02025829
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University Hospitals Cleveland Medical Center
Cystic Fibrosis
Clearing Lungs With Epithelial Sodium Channel (ENaC) Inhibition in Cystic Fibrosis (CF)
The goal of the study is to evaluate the safety and tolerability of P-1037 and to determine whether the combination of P-1037 with hypertonic saline or P-1037 alone has a greater effect on lung function in patients with CF than…
- Trial name
- CLEAN-CF (NCT02343445)
- Testing
- P-1037, Hypertonic Saline, Saline
- Where
- 33 sites in United States
- Volunteers
- 142 people
- Sponsor
- Parion Sciences
Cystic Fibrosis
Virtual Care in CF (VIRTUAL-CF) Study
Cystic fibrosis (CF) is the most common fatal inherited condition in Caucasians, causing recurrent chest infections (pulmonary exacerbations).
- Trial name
- NCT03069651
- Testing
- Virtual Care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Heart of England NHS Trust
Cystic Fibrosis
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor
This is a Phase 3, randomized, double blind, placebo controlled, parallel group, multicenter study in people with cystic fibrosis (CF) who are homozygous for the F508del CF transmembrane conductance regulator (CFTR) gene mutation.
- Trial name
- NCT02347657
- Testing
- VX-661 Plus Ivacaftor Combination, Ivacaftor
- Where
- 74 sites in United States, Canada and 10 more
- Volunteers
- 510 people
- Sponsor
- Vertex Pharmaceuticals Incorporated