Clinical trials: Pulmonary Disease, Chronic Obstructive (COPD)
Ultrasonography, Mechanical Ventilation Weaning
The Use of Diaphragmatic Ultrasonography in Mechanical Ventilation Weaning Decision in COPD Patient
The aim of this study is to evaluate the use of diaphragmatic ultrasonography in taking mechanical ventilation weaning decision and predicting outcome in Chronic obstructive pulmonary disease patient.
- Conditions
- Ultrasonography, Mechanical Ventilation Weaning, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07082361
- Testing
- conventional clinical criteria of weaning from mechanical ventilation, conventional clinical criteria and ultrasonic criteria for weaning
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Tanta University
Chronic Obstructive Pulmonary Disease
Exacerbation Prevention GOLD IV COPD With Non Invasive Mechanical Ventilation
The purpose of this study is to evaluate the efficacy of high-intensity non invasive mechanical ventilation (during one year to reduce the severity and frequency of acute exacerbation of chronic obstructive pulmonary disease…
- Trial name
- NCT01481727
- Testing
- BiPAP Pro 2, Phillips Respironics
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Pulmonary Disease, Chronic Obstructive
Registry of COPD Patients From Outpatient Polyclinic Healthcare Institutions of the Russian Federation in Moscow
To describe the clinical profile of COPD patient who is under outpatient surveillance at polyclinic institutions of Moscow (including demographic data (age, gender, ethnicity, occupation), smoking status, disease duration…
- Trial name
- NCT02853383
- Where
- Russia
- Volunteers
- 2,000 people
- Sponsor
- Interregional Public Organization, Russian Respiratory Society
COPD (Chronic Obstructive Pulmonary Disease)
Induced Sputum Collection in COPD Patients With and Without a Vibroacoustic Device
Induced sputum is a non-invasive method to collect samples from the airways. It involves inhaling a saline mist to loosen mucus, which is then coughed up. The samples are used to study markers of lung disease.
- Trial name
- NCT07751705
- Testing
- Vibroacoustic device, Standard induced sputum collection
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Different Doses of Indacaterol in Chronic Obstructive Pulmonary Disease (COPD)
This study compared the 14-day bronchodilator efficacy of indacaterol with that of placebo and salmeterol.
- Trial name
- NCT01089127
- Testing
- Indacaterol, Salmeterol 50 μg
- Where
- 69 sites in United States
- Volunteers
- 552 people
- Sponsor
- Novartis Pharmaceuticals
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To assess the safety and efficacy of BTVA for the treatment of patients with heterogeneous upper lobe emphysema.
- Trial name
- BTVA (NCT01041586)
- Testing
- BTVA System
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Uptake Medical Corp
Copd
Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease
This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07285642
- Testing
- Aerobic Exercise (Treadmill Walking), Resistance Exercise (Upper and Lower Limb Strength Training), Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Obstructive Pulmonary Disease COPD
A Phase IIa Study to Investigate the Efficacy and Safety of AZD7624 in Chronic Obstructive Pulmonary Disease (COPD) Patients While on Maintenance Therapy
The purpose of this study is to determine whether AZD7624 can reduce acute Chronic Obstructive Pulmonary Disease (COPD) exacerbations in patients on COPD maintenance therapy with a history of frequent acute exacerbations.
- Trial name
- NCT02238483
- Testing
- AZD7624 1.0 mg
- Where
- 41 sites in United States, Argentina and 4 more
- Volunteers
- 213 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
Infection, Heart Failure
Remote Physician Care for Home Hospital Patients
This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04080570
- Testing
- Remote Visit
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation (AF), Heart Failure
Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
People with severe mental illness have a substantially increased risk of undiagnosed and insufficiently treated somatic disease.
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SomaScreen (NCT07518446)
- Testing
- Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
- Where
- Denmark
- Volunteers
- 2,800 people
- Sponsor
- Amager Hospital
COPD, Shortness of Breath
Comparison of Jacobson Relaxation Technique and Pranayama Technique in Patients With COPD
Comparison of Jacobson Relaxation Technique and Pranayama Technique in patients with COPD
- Conditions
- COPD, Shortness of Breath, Quality of Life, Cough
- Trial name
- NCT06463288
- Testing
- Jacobsons Breathing Technique, Pranayama Technique
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
New Technology to Assess Treatment for Chronic Obstructive Pulmonary Disease (COPD)
First, the investigators will image patients with hyperpolarized xenon (Xe) magnetic resonance imaging (MRI) to develop the technique of hyperpolarized xenon MRI at the University of Virginia (UVA).
- Trial name
- NCT02826343
- Testing
- Xenon129 MRI imaging, Gadolinium MRI, Advair (250mcg/50mcg) one puff twice a day
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Obstructive Pulmonary Disease
Isometric Hand Grip Exercise and Lung Function in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable lung disease. People with COPD must work harder to breathe, which can lead to shortness of breath and/or feeling tired.
- Trial name
- NCT06658548
- Testing
- Isometric handgrip exercise training with resistance exercise, Resistance Exercise
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
COPD
The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients
Airway inflammation is partly driven by Th17 and Th17-polarizing cytokines that is steroid-resistant. Statins could suppress IL-17 cytokines in other diseases such as atherosclerosis and multiple sclerosis in mouse model.
- Trial name
- NCT01944176
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Chronic Obstructive Pulmonary Disease
Rehabilitation for Patients With COPD
This study will examine COPD Wellness, a 10-week low-intensity pulmonary rehabilitation program consisting of group and home exercise, education, and social support can improve symptoms and increase physical activity in…
- Trial name
- COPD Wellness (NCT03287440)
- Testing
- COPD Wellness, Health Advocate
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial
A randomised controlled trial to test the hypothesis that inhaled therapies for chronic obstructive pulmonary disease (COPD) have differential effects on the upper airway microbiome.
- Trial name
- MUSIC (NCT02972476)
- Testing
- Budesonide & formoterol fumarate and Aclidinium bromide, Fluticasone 500 & salmeterol and Aclidinium bromide, Fluticasone 250 & salmeterol and Aclidinium bromide
- Where
- 6 sites in United Kingdom
- Volunteers
- 158 people
- Sponsor
- University of Dundee
Chronic Obstructive Pulmonary Disease
During-exercise Physiological Effects of Nasal High-flow in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a major cause of disability and mortality worldwide. This disease progressively leads to dyspnea and exercise capacity impairment.
- Trial name
- AIRVO-PHYSIO (NCT04014868)
- Testing
- Nasal high-flow
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ADIR Association
Chronic Obstructive Pulmonary Disease
PK of CHF6001 in Subjects With Mild, Moderate and Severe Renal Impairment vs. Healthy Volunteers
The purpose of the study is to obtain pharmacokinetics, safety and tolerability data after single administrations of CHF6001 in subjects with mild, moderate and severe renal impairment as well as healthy volunteers under the same…
- Trial name
- NCT05431426
- Testing
- CH6001
- Where
- Bulgaria
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
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