Clinical trials: Pulmonary Disease, Obstructive
Asthma, Allergic Asthma
Children's Respiratory and Environmental Workgroup
The environment during the prenatal period and in early life is a major contributor to the risk of developing childhood asthma. Birth cohort studies from single research centers have identified several factors that affect the…
- Conditions
- Asthma, Allergic Asthma, Allergies, Healthy
- Trial name
- CREW02 (NCT03213184)
- Where
- 10 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Asthma
Inspiratory Flow Using the Osmohaler
The OsmohalerTM is a registered device in Australia. It is used to deliver a dry powder a commercial preparation of mannitol registered as AridolTM to test if a person has irritable airways such as active asthma.
- Trial name
- NCT00531414
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Syntara
Healthy, Smokers
Effect of Whole Body Periodic Acceleration on Airway Endothelial Function
In the present proposal the investigators wish to assess the effect of a single session with the device known as Exer-Rest® which applies Whole Body Periodic Acceleration (WBPA) on baseline airway blood flow (Qaw) and in Qaw…
- Conditions
- Healthy, Smokers, Asthma
- Trial name
- NCT01213706
- Testing
- Whole Body Periodic Acceleration (WBPA)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Miami
Asthma
A Practical Model to Transform Childhood Asthma Care - Spirometry Training in the Primary Care Setting
Spirometry is a recommended component of asthma diagnosis and treatment in the primary care setting, however, few primary care providers report routine use of spirometry in the provision of care for their asthma patients.
- Trial name
- NCT01161433
- Testing
- Virtually delivered spirometry quality improvement program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Washington
Severe Asthma
3TR Asthma Biologics Cohort (ABC) Study
The 3TR-ABC study is a multicentre observational prospective cohort study platform that follows patients with severe asthma from the start of biological therapy and three years onwards.
- Trial name
- 3TR-ABC (NCT06126692)
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Obstructive Pulmonary Disease
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Nebulized Ensifentrine in Healthy Chinese Subjects
This is a phase 1, open-label, parallel cohort study to evaluate the PK, safety and tolerability of nebulized ensifentrine following administration of single and multiple doses in healthy Chinese male subjects.
- Trial name
- NCT05758428
- Testing
- Ensifentrine
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Nuance Pharma (shanghai) Co., Ltd
Allergy, Asthma
Role of Circulating Innate Lymphoid Cells in Allergic Disorders
This study evaluates blood type 2 innate lymphoid cells in participants with mild to moderate asthma and participants with chronic urticaria as compared to healthy adult participants.
- Conditions
- Allergy, Asthma, Urticaria
- Trial name
- NCT03069495
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Low Back Pain, Chronic Pain
Aging, Mobility and Chronic Low Back Pain
Chronic low back pain (CLBP) is very common in older adults and is one of the most common reasons for disability and poor quality of life.
- Trial name
- "Chronic pain" (NCT05167877)
- Testing
- No intervention will be given to the participants
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma, Obesity
Pulmonary Inflammation and Microbiome Changes With Bariatric Surgery in Obese Asthma
The purpose of this study is to gain understanding of mechanisms whereby bariatric surgery modulates pulmonary inflammation and pulmonary microbiome composition and how these changes direct the pathobiology of human obese asthma.
- Trial name
- NCT04247971
- Testing
- Blood draw, Sputum collection, Pulmonary function test
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
Pulmonary Disease, Chronic Obstructive
A Study To Evaluate The Safety And Tolerability Of SB-656933-AAA Following Repeated Doses In Healthy Adult Subjects
To assess safety of SB-656933 following repeat dosing for 14 days.
- Trial name
- NCT00504439
- Testing
- SB-656933-AAA, Simvastatin
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Evaluation in Individuals with COPD and Asymptomatic Individuals
The literature does not provide sufficient information on the evaluation of frailty, handgrip strength, physical activity, kinesiophobia, and fatigue in elderly individuals with Chronic Obstructive Pulmonary Disease and…
- Trial name
- NCT06077357
- Testing
- MMSE Test, PASE Test, The PRISMA-7 Frailty Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Asthma
Online Asthma Self-Management for Children Aged 5-10 and Their Parents
The potential benefits of this research to public health include improved understanding of cultural factors in pediatric asthma self-management, improved self-management skills for children, and better asthma management skills…
- Trial name
- ChildAsthma (NCT02602392)
- Testing
- Lungtropolis, Asthma educational booklet
- Where
- United States
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Chronic Obstructive Pulmonary Disease
A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TQC3302 Inhalation Spray in Healthy Adult Subjects
Groups 1, 3, 4, 5 and 6 of this research team adopted a single-center, open-label design. Group 2 used a three-sequence, three-period crossover design, where participants in this dose group were randomly assigned to the three…
- Trial name
- NCT07267130
- Testing
- TQC3302 inhalation spray, TQC3302 inhalation spray+Tiotropium bromide and olodaterol hydrochloride inhalation spray +Budesonide Powder for Inhalation, Tiotropium bromide and olodaterol hydrochloride inhalation spray +Budesonide Powder for Inhalation+ TQC3302 inhalation spray
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical (Guangzhou) Co., Ltd.
Atopic Disease
Microbiome and Atopy in Mali
This study is about allergic diseases in people living in Mali. Allergic diseases can cause health problems like asthma or skin rashes.
- Trial name
- NCT07051902
- Where
- 2 sites in Mali
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Comparison of Microglial Activation in Severe Asthma and Healthy Controls
The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: How airway inflammation in asthma affects the brain; and, Whether airway inflammation in asthma is…
- Trial name
- MAIA-SC (NCT06299592)
- Testing
- PET/MRI using [18F]FEPPA tracer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Bronchiolitis, Bronchiolitis, Viral
Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis
This study will compare the novel methods of NS and BS with the standard technique of nasophayngeal aspiration (NPA) and routine ETT suction.
- Conditions
- Bronchiolitis, Bronchiolitis, Viral, RSV Infection, Respiratory Failure
- Trial name
- RSV-SAM (NCT03062917)
- Testing
- Nasal and Bronchial Sampling
- Where
- United Kingdom
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Pulmonary Disease, Chronic Obstructive
Study of Safety and Drug Levels of CCI15106 Inhalation Powder in Healthy Adults and Adults With Moderate Chronic Obstructive Pulmonary Disease. Study of CCI15106 Levels in People Standing Near the Person Inhaling the Drug
This single and repeat increasing dose study will collect information on safety, tolerability and drug levels in the body of the CCI15106 inhalation powder.
- Trial name
- NCT03235726
- Testing
- CCI15106
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma, Atopy
Airway Microbiome in Asthma: Relationships to Asthma Phenotype and Inhaled Corticosteroid Treatment
There are new, very sensitive methods for detecting bacteria. These methods show that hundreds of millions of microbes (organisms that can only be seen with microscopes), especially bacteria, live in healthy people.
- Trial name
- NCT01537133
- Testing
- fluticasone
- Where
- 9 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
COPD, Asthma
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
An open label study in 40-60 subjects with diagnosed lung airway disease and in 10-20 normal controls. Each subject will receive PFP as a contrast agent to visualize the airway and alveolar spaces in their lungs using magnetic…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01710449
- Testing
- perfluorinated gas/oxygen mixture
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
Chronic Obstructive Pulmonary Disease
Air as a Placebo: Increasing the Respiratory Performance of People With COPD Through Simple Expectations of Improvement
COPD (Chronic Obstructive Pulmonary Disease) is a disease of the respiratory system characterised by irreversible airway obstruction of varying severity.
- Trial name
- NCT05218564
- Testing
- Oxygen Therapy, Compressed Medical Air
- Where
- Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
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