Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Chronic Obstructive Pulmonary Disease
The Effect of Reflective Breathing Therapy Compared With Conventional Breathing Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) III-IV; part2
The purpose of this study is to determine whether different types of breathing therapies in patients with COPD III-IV decrease dyspnea, increase activity and have impact on parasympathetic activities.
- Trial name
- NCT01905982
- Testing
- reflectory breathing therapy, conventional breathing therapy
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease
A Study About Association Between Microbiome, Metabolome and Clinical Characteristics in COPD Patients
The goal of this observational registry study is to compare characteristics of gut and sputum microbiome and metabolome among COPD patients with significant smoking history, COPD patients without significant smoking history and…
- Trial name
- NCT06101459
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Atrial Fibrillation (AF), Heart Failure
Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
People with severe mental illness have a substantially increased risk of undiagnosed and insufficiently treated somatic disease.
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SomaScreen (NCT07518446)
- Testing
- Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
- Where
- Denmark
- Volunteers
- 2,800 people
- Sponsor
- Amager Hospital
COPD, Chronic Hypercapnic Respiratory Failure
Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics
Nasal High Oxygen Flow (HOF) has been demonstrated to reduce the re-intubation rate in hypoxic patients and ameliorate breathing pattern in hypercapnic patients.
- Trial name
- NCT02363920
- Testing
- HOF, noninvasive mechanical ventilation (NIV)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hypoxia, COPD
Intelligent Oxygen Therapy During Activities of Daily Living
The aim of this study is to assess whether an auto-titrating oxygen system can maintain constant oxygen saturations (SpO2) in patients who are on long-term oxygen therapy (LTOT) during activities of daily living.
- Conditions
- Hypoxia, COPD, Hyperoxia
- Trial name
- NCT02683486
- Testing
- Intelligent oxygen therapy (an auto-titrating oxygen system), Long-term oxygen therapy
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety of Tiotropium and Atrovent in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
To compare the bronchodilator efficacy and safety of tiotropium inhalation capsules (18 µg once daily) and Atrovent® MDI (2 puffs of 20µg q.i.d.) among Filipino patients with COPD
- Trial name
- NCT02172469
- Testing
- Tiotropium inhalation powder capsule, Ipratropium Bromide Metered Dose Inhaler
- Volunteers
- 215 people
- Sponsor
- Boehringer Ingelheim
COPD, Dyspnea
Is Reduced Hypoxia Through a Robot Intervention, Associated With Sensory and Emotional Descriptions of Dyspnea, Anxiety, Depression, Symptom Burden and Anxiolytics
Chronic Obstructive Pulmonary Disease (COPD) is associated with high morbidity and mortality. The Danish Lung Association estimates that 320,000 Danes live with COPD, of which approximately 50,000 with severe COPD.
- Conditions
- COPD, Dyspnea, Anxiety, Depressive Symptoms
- Trial name
- NCT04375917
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Chronic Obstructive Pulmonary Disease
Clinical Trial of Efficacy and Safety of Rengalin in the Treatment of Cough in Patients With Chronic Obstructive Pulmonary Disease
The purpose of this study is to obtain additional data on efficacy and safety of Rengalin in the treatment of cough in patients with stable obstructive pulmonary disease
- Trial name
- NCT03159091
- Testing
- Rengalin
- Where
- 18 sites in Russia
- Volunteers
- 238 people
- Sponsor
- Materia Medica Holding
COPD Exacerbation Acute
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2
The proposed study will explore whether remote monitoring of a COPD patient can be undertaken using a wearable medical device.
- Trial name
- BREATH-TRACHER (NCT06419062)
- Testing
- Frontier X2
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Strathclyde
Chronic Bronchitis, Chronic Obstructive Pulmonary Disease
A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)
The purpose of this study was to evaluate the effect of ION-827359 on forced expiratory volume in 1 second (FEV1) in participants with mild to moderate COPD with CB.
- Trial name
- NCT04441788
- Testing
- ION-827359
- Where
- 15 sites in Czechia, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Chronic Obstructive Pulmonary Disease (COPD), Frailty
Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Program
Frailty is common among older patients with chronic obstructive pulmonary disease (COPD) and is associated with poor functional outcomes and increased health risks.
- Trial name
- COPD-FRAIL (NCT07519603)
- Testing
- Vivifrail Exercise program, Usual Care Group
- Where
- 2 sites in Vietnam
- Volunteers
- 80 people
- Sponsor
- National Geriatric Hospital
COPD
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a preventable respiratory characterized by airflow obstruction that is not fully reversible. This disease a major cause of mortality worldwide.
- Trial name
- COPD (NCT03577080)
- Testing
- ET+RT+ NMES
- Where
- Tunisia
- Volunteers
- 42 people
- Sponsor
- Faculty of Medicine, Sousse
Pulmonary Disease, Chronic Obstructive, Heart Failure
Telehealth Program in Chronic Patients
The aim of this randomized control study is to determine the feasibility and efficacy of an innovative multidisciplinary telehealth program in chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients.
- Trial name
- NCT02269618
- Testing
- Home-based telehealth program, Home-based rehabilitation, Usual care
- Where
- 3 sites in Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione Salvatore Maugeri
Smoking, COPD
Integrative-omics of the Disordered COPD Small Airway Epithelium
We aim to use an integrated network systems approach to analyze certain existing small airway epithelium (SAE) omic data sets at the genetic, epigenetic (methylation), gene expression, microRNA and metabolomic levels, to develop…
- Trial name
- NCT02183818
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks…
- Trial name
- PERFECT (NCT03496623)
- Testing
- Inhaled treprostinil solution
- Where
- 76 sites in United States, Argentina and 2 more
- Volunteers
- 188 people
- Sponsor
- United Therapeutics
Chronic Obstructive Pulmonary Disease (COPD)
Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract
The colonization of potential pathogenic bacteria in lower respiratory tract is thought to be accountable for acute exacerbation in subjects with moderate to severe COPD.
- Trial name
- PAEAN (NCT03449459)
- Testing
- oral probiotics, aerosol inhaled amikacin, combined vaccination
- Where
- 3 sites in China
- Volunteers
- 144 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Obstructive Pulmonary Disease
Morphine, Dyspnea, Exercise and COPD
The investigators are studying the effect of a single dose Opioid drug (Morphine) on dyspnea and exercise tolerance in COPD patients.
- Trial name
- NCT01718496
- Testing
- Morphine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Emphysema, COPD
Bronchoreversibility and Radiologic Morphology of Emphysema
To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema…
- Trial name
- NCT02008162
- Testing
- Bronchodilators
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Rome Tor Vergata
Chronic Obstructive Pulmonary Disease
Capnometry-Assisted Breathing Training for COPD
Capnometry-Assisted Breathing Training for COPD (CATCH) is a behavioral intervention that aims to promote optimal, self-regulated, mindful breathing.
- Trial name
- CATCH (NCT03457103)
- Testing
- Capnometry-Assisted Training for COPD to Slow the Breath (CATCH), Pulmonary Rehabilitation (PR)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- NYU Langone Health
Chronic Obstructive Pulmonary Disease
Observational Study to Evaluate Health Status of Chronic Obstructive Pulmonary Disease (COPD) Patients in Response to Real-life Treatments in Thailand
The purpose of this study is to evaluate health status of uncontrolled Chronic Obstructive Pulmonary Disease (COPD) patients in response to treatments in clinical practice.
- Trial name
- NCT01169727
- Where
- 20 sites in Thailand
- Volunteers
- 684 people
- Sponsor
- AstraZeneca
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