Clinical trials: Pulmonary Disease (COPD), Chronic Obstructive
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease Markers and Prognosis
The study aim is to verify the association between the changes in markers of disease and patient´s prognosis in chronic obstructive pulmonary disease.
- Trial name
- NCT00605540
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Comparison of Two Programs to Encourage Physical Activity in Individuals With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. Symptoms include shortness of breath, wheezing, and difficulty exercising.
- Trial name
- NCT00328484
- Testing
- Lifestyle Activity Program, Exercise Program
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Disease, Chronic Obstructive
Study of SB681323 and Prednisolone on Biomarkers in COPD (Chronic Obstructive Pulmonary Disease) Patients
This study will assess the effects of single oral doses of SB681323 and prednisolone on biomarkers in induced sputum and blood COPD patients
- Trial name
- NCT00380133
- Testing
- SB681323, Prednisolone
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease (COPD)
Impact of Family-based Pulmonary Rehabilitation (PR) on Patients With Chronic Obstructive Pulmonary Disease (COPD) and Their Family Members
The purpose of this study is to explore the impact of Family-based pulmonary rehabilitation (PR) on patients with chronic obstructive pulmonary disease (COPD) and their family members.
- Trial name
- NCT02048306
- Testing
- Family-based PR program, Conventional PR program
- Where
- Portugal
- Volunteers
- 56 people
- Sponsor
- Aveiro University
Pulmonary Disease, Chronic Obstructive
Study to Evaluate Efficacy and Safety of Mepolizumab for Frequently Exacerbating Chronic Obstructive Pulmonary Disease (COPD) Patients
This is a multi-center, randomized, placebo-controlled, double-blind, parallel group trial evaluating mepolizumab 100 mg against placebo given every 4 weeks through subcutaneous (SC) injection.
- Trial name
- NCT02105948
- Testing
- Mepolizumab
- Where
- 116 sites in United States, Australia and 14 more
- Volunteers
- 837 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Physiological Study of Minimally Invasive ECCO2R in Exacerbations of COPD Requiring Invasive Mechanical Ventilation
Morbidity and mortality in COPD result largely of acute exacerbations.The optimization of the respiratory management represents a fundamental challenge for improving prognosis and reducing mortality.
- Trial name
- EPHEBE (NCT02586948)
- Testing
- extracorporeal CO2 removal (Hemolung device)
- Where
- 3 sites in France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD, Eosinophilia
Home Air Purification for Eosinophilic COPD
This study evaluates the influence of home air purification on the lung health of adults with eosinophilic COPD. Half of the participants will receive real air purifiers (HEPA filters) and half will receive sham air purifiers.
- Trial name
- NCT04252235
- Testing
- Air purifier
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pulmonary Disease, Chronic Obstructive
Feasibility and Effect of a Follow up Tele-rehabilitation Program for Chronic Obstructive Lung Disease vs. Standard Follow up
Introduction In order to guarantee chronic patients \& elderly a high quality service from health care organizations in the coming decades, new technologies have been implemented to treat patients from a distance.
- Trial name
- 2-TELEKOL (NCT03443817)
- Testing
- Tele rehab
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease, Emphysema
Home-based Health Management of Chronic Obstructive Lung Disease (COPD) Patients
Regular physical activity has been found to be important in maintaining health and well-being in people with COPD. The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more…
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Pulmonary Rehabilitation
- Trial name
- NCT02999685
- Testing
- Home-base Pulmonary Rehab with Health Coaching
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Mayo Clinic
Pulmonary Disease, Chronic Obstructive
Venovenous CO2 Removal (VVCO2R) in Patients With COPD and Acute Respiratory Failure
The purpose of this study to determine the safety and effectiveness of a mechanical device to remove carbon dioxide from the blood of patients with chronic obstructive pulmonary disease (COPD)when they are hospitalized in the…
- Trial name
- VVCO2R (NCT00594009)
- Testing
- Venovenous CO2 Removal (VVCO2R) in COPD
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Chronic Obstructive Pulmonary Disease
A Phase 1b Study to Evaluate the Safety and PK of MP-376 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from frequent and recurrent acute exacerbations (AECB) which are associated with enormous healthcare expenditures and significant morbidity, specifically an…
- Trial name
- NCT00752414
- Testing
- MP-376 (Levofloxacin solution for Inhalation)
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Amgen
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety Study of Two Dose Levels of AZD2115 in Subjects With Moderate to Severe COPD
This is a phase IIa dose-ranging, randomized, double-blind, chronic-dosing (14 Days), three-period, placebo-controlled, multi-center, cross-over study to assess the efficacy and safety of two dose levels of a dual pharmacology…
- Trial name
- NCT02109406
- Testing
- AZD2115 Dose 1, AZD 2115, Dose 2
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Pearl Therapeutics, Inc.
Healthy, COPD
Closing Volume Interpretation and Bronchodilators Effect
The gold standard measures to evaluate small airways (SAW) "in vivo" is not well understood Two tests are today used to measure SAW but real results concordance is not clear These problems have a small evidence Data about real…
- Trial name
- NCT01437748
- Testing
- Indacaterol maleate, Tiotropium bromide
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Milan
Asthma, COPD
A Clinical Study in Healthy Subjects to Evaluate 9MW1911 Injection
This is a Phase 1, randomized, placebo-controlled study, enrolling approximately 38 healthy adult subjects (18-65 yrs). The purpose of this study is to evaluate the safety, tolerability and PK of single ascending dose of 9MW1911…
- Conditions
- Asthma, COPD, Atopic Dermatitis
- Trial name
- NCT05170243
- Testing
- 9MW1911 Injection
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Chronic Obstructive Pulmonary Disease
REported Outcomes in COPD With Trixeo in Real worlD in Germany
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms (including breathlessness, cough, and sputum production), which has a substantial impact on health-related quality of life (HRQoL).
- Trial name
- RECORD (NCT05311306)
- Where
- 62 sites in Germany
- Volunteers
- 475 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Emphysema
LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves
A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves.
- Trial name
- BLOOD-VALVES (NCT03010449)
- Testing
- Intra-bronchial valve and blood
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
Fractional Exhaled Nitric Oxide and Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with recurrent exacerbations despite guideline-based therapy.
- Trial name
- NCT07396311
- Testing
- No intervention assigned
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Obstructive Pulmonary Disease
A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.
This is a phase II clinical trial to evaluate the efficacy and safety of TQC3721 Suspension for Inhalation in patients with moderate to severe Chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT05987371
- Testing
- TQC3721 suspension for inhalation, Salbutamol sulfate inhalation aerosol
- Where
- 11 sites in China
- Volunteers
- 75 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Obstructive Pulmonary Disease (COPD)
The CAPTURE Study: Validating a Unique COPD Case Finding Tool in Primary Care (Aim 3)
A prospective, multicenter study including a cross-section validation to define sensitivity and specificity of CAPTURE to identify previously undiagnosed patients with clinically significant Chronic Obstructive Pulmonary Disease…
- Trial name
- CAPTURE (NCT03583099)
- Testing
- COPD plus CAPTURE education and patient-level information, COPD Education Only
- Where
- 9 sites in United States
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Obstructive Pulmonary Disease, COPD
Clinical Trial Comparing the Pharmacological Effects of EP395 With Placebo in Healthy Adults
This study aims to assess the effect of EP395 against an induced inflammation of the lung. In addition, further data about the safety and tolerability of EP395 will be collected.
- Trial name
- NCT05516316
- Testing
- EP395
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- EpiEndo Pharmaceuticals
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