Clinical trials: Pulmonary Disorder, Chronic Obstructive
Lung Diseases
Analysis of Anti-inflammatory and Antioxidant Pathways in Lung Diseases by Haem Oxygenase-1 (HO-1) in Induced Sputum and Carbon Monoxide (CO) in Exhaled Air
This work will focus on the anti-inflammatory and antioxidant pathways in lung diseases by measuring HO-1 in induced sputum and CO in exhaled air in cases of four respiratory diseases, asthma, chronic obstructive pulmonary…
- Trial name
- NCT01140685
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Respiratory Disease, COPD
Chronic Respiratory Disease Burden in Bangladesh
Chronic Respiratory Disease (CRD), particularly asthma and chronic obstructive pulmonary disorders (COPD) are leading causes of mortality and reduced quality of life due to its wide-reported association with other…
- Trial name
- NCT04851808
- Where
- Bangladesh
- Volunteers
- 981 people, healthy volunteers welcome
- Sponsor
- Child Health Research Foundation, Bangladesh
IPF, Sarcoidosis
Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases
Nasal, tracheal and bronchial sampling of MLF in patients with idiopathic pulmonary fibrosis(IPF), sarcoidosis, tuberculosis(TB), asthma and COPD. Similar sampling from healthy controls for comparative data.
- Conditions
- IPF, Sarcoidosis, Tuberculosis, Asthma
- Trial name
- RESPI-SAM (NCT02807025)
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Cholecystitis, Chronic
Outcomes of Three Ports Versus Four Ports Laparoscopic Cholecystectomy, Sohag General Surgery Department Experience
To compare the outcomes of three ports and four ports Laparoscopic Cholecystectomy
- Trial name
- NCT06264115
- Testing
- Laparoscopic Cholecystectomy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
COPD
Sedentary Behaviour, Physical Activity and Cardiometabolic Risk in Chronic Obstructive Pulmonary Disease
Investigation into the associations between sedentary behaviour, physical activity, body composition and cardiometabolic risk in COPD.
- Trial name
- SPAaRC (NCT03157817)
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Asthma, COPD
MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects
The purpose of this clinical trial is to demonstrate hyperpolarized xenon (HXe) as a medical imaging drug (agent) for Magnetic Resonance Imaging (MRI) of the human lung ventilation.
- Conditions
- Asthma, COPD, Healthy
- Trial name
- HXe-VENT (NCT01833390)
- Testing
- HXe MRI lung ventilation
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Xemed LLC
COPD, Emphysema
Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease
The aim of this study is to investigate the mechanisms whereby lung function is decreased in COPD. The hypothesis is that in diseases such as COPD, inflammatory cells including neutrophils, macrophages and lymphocytes migrate to…
- Trial name
- NCT00147095
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Low Back Pain
Measurement of Substance P in Saliva of Low Back Pain Patients
The purpose of this study is to compare the levels of Substance P in saliva, in patients with severe chronic low back pain and in subjects without it.
- Trial name
- NCT00735735
- Testing
- The taking of a saliva sample from each subject.
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kovacs Foundation
Chronic Obstructive Pulmonary Disease (COPD), Preserved Ratio Impaired Spirometry (PRISM)
Comparison of Clinical Status of Individuals With COPD and Preserved Ratio Impaired Spirometry
Despite the globally varying high prevalence rate of the PRISm phenotype, there are no guidelines for its diagnostic evaluation and management.
- Trial name
- NCT06682832
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Obstructive Lung Disease
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine whether genetic factors contribute to an individuals risk of developing obstructive lung disease from smoking cigarettes.
- Trial name
- NCT00018408
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic Obstructive Pulmonary Disease, Asthma
Lung Deposition of Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide Administered Via pMDI in Healthy, Asthmatic and COPD Patients
The purpose of this study is to investigate the lung deposition and distribution pattern of Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium Bromide using a Gamma-scintigraphic technique after inhalation of a single…
- Trial name
- NCT02975843
- Testing
- Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease (COPD)
Temple Health Chest Initiative (THCI 2.0)
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare…
- Trial name
- NCT06933758
- Testing
- Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Temple University
Chronic Obstructive Pulmonary Disease
GECo: Implementation and Effectiveness of COPD Self Management Action Plans in Low and Middle Income Countries
This study will randomise people with clinically significant COPD (GOLD Grade B-D) to usual care or provision of a self-management action plan supported by monthly follow-up visits from a community health worker trained in the…
- Trial name
- GECo2 (NCT03359915)
- Testing
- COPD Self-Management Plan
- Where
- 3 sites in Nepal, Peru and 1 more
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
- Trial name
- NCT02209974
- Testing
- Fluticasone
- Where
- Spain
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hospital Son Llatzer
Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia
Screening for Pulmonary Embolism Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 500 patients 18 years old and older (300 patients in the training sample and 200 patients in the test…
- Conditions
- Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07412418
- Where
- Russia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Asthma, COPD
Bioequivalence Study to Assess Systemic Exposure of FP and SAL FDC From Different DPIs
This is a crossover study to assess the systemic pharmacokinetics of fluticasone propionate (FP) and salmeterol (SAL). Study medication will be administered as fixed dose combinations (250 µg FP and 50 µg SAL) from the Advair®…
- Trial name
- NCT02215122
- Testing
- MGR001, Advair® Diskus®, Seretide™ Accuhaler™
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mylan Pharma UK Ltd.
Pulmonary Disease, Chronic Obstructive
The Effect of Mobile Health Applications on Symptom Control, Self-efficacy and Chronic Disease Management in COPD
Name:The effect of the mobile application developed to provide symptom control in chronic obstructive pulmonary patients on self-efficacy and chronic disease management Aim:Considering the covid-19 pandemic seen all over the…
- Trial name
- NCT05295901
- Testing
- mKOAH application
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Copd, Smoking
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco.
- Conditions
- Copd, Smoking, Tobacco Use
- Trial name
- Pre-COPD Pilot (NCT04722835)
- Testing
- Bronchoscopy with Bronchoalveolar Lavage (BAL)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
The Chronic Obstructive Pulmonary Disease Fish Oil Pilot Trial
Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the United States. Unlike the other leading causes of death, no medical therapies currently available improve the course of disease or…
- Trial name
- COD-Fish (NCT00835289)
- Testing
- n-3 polyunsaturated fatty acids
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
COPD, Emphysema
Anti-Platelets in Chronic Obstructive Pulmonary Disease
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e.
- Conditions
- COPD, Emphysema, Emphysema or COPD
- Trial name
- NCT05567562
- Testing
- dual anti-platelet therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
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