Clinical trials: Pulmonary Dysfunction, open to volunteers
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Diaphragm Injury, Respiratory Failure
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
- Conditions
- Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- DIASPORA (NCT03667027)
- Testing
- Respiratory support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Chronic Lung Allograft Dysfunction Lung MRI (CLAD)
Chronic Lung Allograft Dysfunction MRI Study
This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology.
- Trial name
- NCT06406777
- Testing
- Spirometry, Contrast Lung Computed Tomography (CT) Scan, Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sean Fain
Chronic Rejection of Lung Transplant
Noninvasive Early Detection of Lung Allograft Dysfunction After Lung Transplantation With Multiple Breath Washout Test
Chronic rejection, more commonly called bronchiolitis obliterans syndrome (BOS), is the leading cause of death beyond the first year post lung transplantation.
- Trial name
- NCT05586906
- Testing
- Multiple Breath Washout (MBW) tests
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Congenital Heart Disease, Heart Failure
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
Advances in surgical and medical care have led to improved outcomes in patients with congenital heart disease (CHD). As a consequence, the majority of patients nowadays survives to adulthood (adults with CHD, that is, adult CHD…
- Conditions
- Congenital Heart Disease, Heart Failure, Transplant; Complication, Failure, Arrythmia
- Trial name
- ARTORIA-R (NCT04848844)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Covid19, Olfactory Dysfunction
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function.
- Trial name
- DysOSMIC (NCT06482138)
- Testing
- Biopsy and Cytobrush
- Where
- 7 sites in Belgium, Germany and 1 more
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pulmonary Embolism, Hematopoiesis
Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders.
- Trial name
- HEMEP (NCT04711746)
- Testing
- blood sample
- Where
- France
- Volunteers
- 544 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
CTEPH
Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)
1. To identify biological sex differences in baseline RV function in CTEPH 2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH 3.
- Trial name
- NCT06105242
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Respiratory Failure, Endothelial Dysfunction
Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure
The purpose of this clinical trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in 450 mechanically ventilated patients with infectious…
- Conditions
- Acute Respiratory Failure, Endothelial Dysfunction, Pulmonary Infection
- Trial name
- COMBAT-ARF (NCT06319274)
- Testing
- Iloprost, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 450 people
- Sponsor
- Pär Johansson
COVID-19, Antibody COVID-19
The Role of Obesity in Severe COVID-19 Pathophysiology
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide.
- Trial name
- SAMO (NCT06968442)
- Testing
- Venipuncture
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Franciscus Gasthuis
Stroke, Mild Cognitive Impairment
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment, Vestibular Diseases, Long Covid19
- Trial name
- TeleRehab DSS (NCT06534164)
- Testing
- Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 460 people
- Sponsor
- University College, London
COPD, Pulmonary Hypertension
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during…
- Conditions
- COPD, Pulmonary Hypertension, Right Ventricular Dysfunction, Exercise
- Trial name
- NCT05896579
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
FEED-Cystic Fibrosis (FEED-CF)
The goal of this study is to determine the extent to which excess dietary sugars serve as a precipitating factor in glucose intolerance in adults with cystic fibrosis (CF), a population at especially high risk for a unique form…
- Trial name
- FEED-CF (NCT05766774)
- Testing
- Low-added sugar, high-fat diet, High-added sugar, high-fat CF diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Acute Pulmonary Embolism
HOME-PE2 : Home Treatment Versus Hospitalization in Patients With Acute Pulmonary Embolism, no Clinical Severity Criteria, and Either Right Ventricular Dysfunction or Elevated Troponin: a Randomized Controlled Trial
This study (HOME-PE2) is a multicenter, randomized controlled trial comparing home treatment versus hospitalization in patients with acute pulmonary embolism (PE) who have no clinical severity criteria according to the Hestia…
- Trial name
- HOME-PE2 (NCT07506291)
- Testing
- Home treatment, Hospitalization
- Where
- 18 sites in France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Angers
COPD, Bronchial Asthma
Effects of Pulmonary Diseases and Their Treatment on Cardiac Function
While the bidirectional relationship between the lung and the right heart are well studied, the cardiopulmonary interactions between the lung and the left heart are largely unresearched and not well understood.
- Conditions
- COPD, Bronchial Asthma, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT05042219
- Testing
- Cardiac MRI
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Ayham Daher
Right Heart Failure, Right Ventricular Dysfunction
Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation
In cardiac surgery, the presence of pulmonary hypertension (PH) is a prognostic factor associated with increased mortality and morbidity.
- Trial name
- MILAN (NCT05450328)
- Testing
- Combined Epoprostenol Sodium & Milrinone, Normal saline
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Acute Lung Injury(ALI), Liver Cirrhosis
Digital Early Warning System for Acute Lung Injury in Liver Surgery
This study aims to develop an explainable machine learning model that takes into account the characteristics of cardiopulmonary interactions.
- Conditions
- Acute Lung Injury(ALI), Liver Cirrhosis, ARDS, Human, MASLD
- Trial name
- NCT07070362
- Where
- 4 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital