Clinical trials: Pulmonary Embolism
Deep Vein Thrombosis
Venous Thromboembolism (VTE) Treatment Study in Japanese Deep Vein Thrombosis (DVT) Patients
The objective of this study is to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of two different dosages of rivaroxaban in the treatment of deep vein thrombosis (DVT) and the prevention of the…
- Trial name
- NCT01516840
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Unfractionated heparin, Warfarin
- Where
- 29 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Bayer
Pulmonary Embolism
Diagnostic Accuracy of Arterial-alveolar Oxygen Gradient in Low Risk Patients With Suspected Pulmonary Embolism
Introduction: The diagnosis of pulmonary embolism (PE) is a challenge in the Emergency Department. D-dimer based diagnostic algorithms for PE have a very high sensitivity, but rely upon a vast amount of CT angiography and…
- Trial name
- DAGPE (NCT06043726)
- Testing
- Laboratory testing: D-dimeer and astrup
- Where
- Netherlands
- Volunteers
- 230 people
- Sponsor
- Franciscus Gasthuis
Thrombosis, Pulmonary Embolism
Association of Anti-factor Xa Activity With Venous Thromboembolism in Critically Ill Patients
The goal of this observational study is to analyse the association between anti-factor Xa activity (antiXa) and the occurence of venous thromboembolism (VTE; either deep vein thrombosis and/or pulmonary embolism) in critically…
- Conditions
- Thrombosis, Pulmonary Embolism, Enoxaparin
- Trial name
- AntiXa-ICU (NCT06357403)
- Testing
- Anti-factor Xa activity calibrated for enoxaparin
- Where
- 3 sites in Austria
- Volunteers
- 1,300 people
- Sponsor
- Medical University of Vienna
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Feasibility and Safety of Total Percutaneous Closure of Femoral Arterial Access Sites in the Veno-arterial ECMO Patients
The most frequent access site for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the common femoral artery (CFA), using either an open or percutaneous technique.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Myocarditis, Hypertension, Pulmonary
- Trial name
- NCT04689451
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Pulmonary Embolism
European Database on Catheter-directed Treatment of Pulmonary Embolism.
The main goals of EuroPE-CDT is to assess the currently applied catheter-directed treatment (CTD) techniques and strategies in pulmonary embolism (PE) patients and to determine the short term efficacy and safety of this invasive…
- Trial name
- EuroPE-CDT (NCT04037423)
- Where
- Poland
- Volunteers
- 145 people
- Sponsor
- Medical University of Warsaw
Pulmonary Embolism
Pulmonary Embolism in Pregnancy: Biomarkers and Clinical Predictive Models
Objective: To evaluate whether trimester specific d-dimer levels and brain natriuretic protein (BNP), along with the modified Wells score (MWS), is a useful risk stratification tool to exclude pregnant women at low-risk of…
- Trial name
- NCT02709174
- Testing
- blood draw
- Volunteers
- 59 people
- Sponsor
- Wake Forest University Health Sciences
Thrombosis, Deep Vein, Pulmonary Embolism
A Study of Adverse Events and Suspected Adverse Drug Reactions of Patients Under Treatment of Apixaban for Venous Thomboembolism (VTE) Treatment
Number, type and incidence of adverse events/suspected adverse drug reactions in patients treated with apixaban, according to therapeutic indications approved in Mexico.
- Trial name
- NCT03812835
- Sponsor
- Pfizer
Acute Pulmonary Embolism
Saline Contrast Electrical Impedance Tomography Method for Diagnosis of Acute Pulmonary Embolism
The goal of this observational study is to compare the consistency of saline contrast Electrical Impedance Tomography(EIT) method and Computed Tomography Pulmonary Angiography (CTPA) in diagnosing acute pulmonary embolism.
- Trial name
- ECTPED (NCT07190079)
- Testing
- Saline contrast Electrical Impedance Tomography method, Computed Tomography Pulmonary Angiography (CTPA)
- Where
- China
- Volunteers
- 343 people
- Sponsor
- Peking Union Medical College Hospital
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Pulmonary Embolism, Dyspnea
PERCEPIC: PERC Rule Combined With Implicit Low Clinical Probability
PERC rule was created to rule out pulmonary embolism (PE) without further exams, with residual PE risk <2%. Its safety is currently confirmed in low PE prevalence populations as north-American.
- Conditions
- Pulmonary Embolism, Dyspnea, Thoracic Pain
- Trial name
- PERCEPIC (NCT02360540)
- Testing
- Gestalt estimation
- Where
- 12 sites in Belgium, France
- Volunteers
- 1,773 people
- Sponsor
- University Hospital, Angers
Sepsis, Blood Coagulation Disorders
Analysis of the Coagulopathy Developed by COVID-19 Infected Patients
Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death.
- Conditions
- Sepsis, Blood Coagulation Disorders, Thrombin, Disseminated Intravascular Coagulation
- Trial name
- COVID-TGT (NCT04356950)
- Testing
- Thrombin generation test assay, Fibrin generation markers assays
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pulmonary Embolism
Electronic Support for Pulmonary Embolism Emergency Disposition
To evaluate the impact of an integrated electronic clinical decision support system to facilitate risk stratification and site-of-care decision-making for patients with acute pulmonary embolism.
- Trial name
- eSPEED (NCT03601676)
- Testing
- Integration of electronic clinical decision support
- Where
- 14 sites in United States
- Volunteers
- 1,703 people
- Sponsor
- Kaiser Permanente
Pulmonary Embolism
Risk Assessment Strategies in Pulmonary Embolism
The aim of this study is to evaluate different scores of risk assessment in patients with pulmonary embolism. This study aim to compare the accuracy of these scores in predicting mortality during hospital admission.
- Trial name
- NCT04327960
- Testing
- Cardiac troponin (cTn)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Oral Anticoagulation, Deep Venous Thrombosis
Pharmacodynamic Drug Interaction Between Warfarin and Amoxicillin-clavulanic Acid
Several case reports indicate that the use of the antibiotic combination amoxicillin and clavulanic acid (AM-CLAVAC) can interact with warfarin pharmacodynamics.
- Conditions
- Oral Anticoagulation, Deep Venous Thrombosis, Atrial Fibrillation, Pulmonary Embolism
- Trial name
- INWARA (NCT00603317)
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Venous Thrombosis, Pulmonary Embolism
Genetic Determinants of Warfarin Anticoagulation Effect
The response to warfarin varies greatly among individuals. Some of this variability can be ascribed to genetic polymorphisms in the gene encoding for CYP2C9, the enzyme mediating the metabolism of S warfarin.
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation
- Trial name
- NCT00162435
- Testing
- Warfarin
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Atrial Fibrillation, Deep Vein Thrombosis
A Pharmacogenetic Study of Warfarin Dosing, "The COUMA-GEN Study"
Anticoagulation with warfarin is a common and potentially hazardous therapeutic intervention. It is a leading cause of iatrogenic bleeding events and, hence, of malpractice claims.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT00334464
- Testing
- Standard of care or genotyping dosing of warfarin dosing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
Deep Venous Thrombosis, Pulmonary Embolism
The DARE Warfarin CER Study
Approximately half a million Americans annually experience venous thromboembolic disease, including deep venous thrombosis (DVT) and pulmonary embolism (PE).
- Trial name
- NCT03271450
- Testing
- Dabigatran: extended treatment (e.g at least 90 days), Dabigatran: extended treatment (e.g at least 180 days), Dabigatran: extended treatment (e.g at least 270 days)
- Where
- United States
- Volunteers
- 416,000 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Embolism (PE)
ULTRAsound-assisted Catheter-guided Thrombolysis for Intermediate-high Risk Patients With PE
Pulmonary embolism (PE) is a life-threatening condition and a leading cause of cardiovascular mortality. While systemic thrombolysis is the standard treatment for high-risk PE, its bleeding risk limits use in some patients…
- Trial name
- ULTRA-PE (NCT07452991)
- Testing
- Ultrasound-assisted Catheter-guided Thrombolysis
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Venous Thromboembolism, Pulmonary Embolism
Prediction of the COBRRA VTE Anticoagulant Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, DVT
- Trial name
- NCT05264168
- Testing
- Rivaroxaban, Apixaban
- Where
- United States
- Volunteers
- 41,875 people
- Sponsor
- Brigham and Women's Hospital
Chronic Pulmonary Thromboembolism
Early Detection of CTEPH in Patients After APE
The project is a national, prospective, multicenter, observational pilot project of screening CTEPH in pacients after APE in the Czech Republic.
- Trial name
- CTEPH (NCT06865326)
- Testing
- Standardized CTEPH Screening Protocol
- Where
- 10 sites in Czechia
- Volunteers
- 500 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic