Clinical trials: Pulmonary Failure
Congestive Heart Failure
Preoperative Significant Clinical Findings Using Focused Ultrasound Examination
The purpose of this study is to determine whether a focused ultrasound examination for the heart, lungs and abdomen, preformed by a trained anesthesiologist, can reveal significant clinical findings in elderly patients before…
- Trial name
- NCT02824692
- Testing
- heart lungs and abdomen ultrasound
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Advanced Solid Tumors
A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects
The purpose of this clinical study is to establish the safety profile, determine the maximum tolerated dose (MTD) and recommend a Phase 2 dose (RP2D) and schedule of SRA737 in combination with low dose gemcitabine; and to…
- Trial name
- NCT02797977
- Testing
- SRA737, gemcitabine, cisplatin, SRA737, gemcitabine
- Where
- 20 sites in Spain, United Kingdom
- Volunteers
- 153 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Pulmonary Hypertension, Diastolic Heart Failure
Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure
Prevalence of heart failure (HF) with left ventricular (LV) diastolic dysfunction and preserved ejection fraction (EF) (HFpEF) is increasing.
- Trial name
- NCT01156636
- Testing
- Sildenafil
- Volunteers
- 44 people
- Sponsor
- University of Milan
Cardiovascular Disease Acute, Emergency Department Patient
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
The aim of this study is to assess emergency medicine physician and advanced practice provider (APP) knowledge and technical skill in performance of a point-of-care ultrasound simulation and just-in-time training pathway to…
- Conditions
- Cardiovascular Disease Acute, Emergency Department Patient, Heart Failure Acute, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07159269
- Testing
- Cardiac point-of-care ultrasound (POCUS) training and clinical pathway
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Duke University
Nonsquamous Non-Small Cell Lung Cancer
A Study of Sintilimab or Placebo in Combination With Chemotherapy as Second-line Treatment for Patients With Stage IV Nonsquamous Non-small Cell Lung Cancer With Wild-type EGFR After Failure With Platinum-Containing Chemotherapy.
This prospective, single-center, randomized, controlled study will evaluate the efficacy and safety of sintilimab or placebo in combination with chemotherapy as second-line treatment for patients with stage IV nonsquamous…
- Trial name
- NCT03863483
- Testing
- Sintilimab, Docetaxel, Pemetrexed
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xin-Hua Xu
Neoplasms, Heart Failure
Preparing Family Caregivers to Make Medical Decisions for Their Loved Ones
The overarching goal of the project is to improve the process and experience of surrogate decision-making by family caregivers. Since feeling unprepared to make surrogate decisions is a major contributor to caregiver stress, the…
- Conditions
- Neoplasms, Heart Failure, Kidney Diseases, Lung Diseases
- Trial name
- NCT02429479
- Testing
- Making Your Wishes Known, Standard advance care planning
- Where
- 2 sites in United States
- Volunteers
- 285 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Respiratory Distress Syndrome (ARDS), ARDS
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT06703073
- Testing
- Cohort A: vilobelimab, Cohort B: paridiprubart, Cohort C: bevacizumab
- Where
- 41 sites in United States
- Volunteers
- 600 people
- Sponsor
- PPD Development, LP
Non Small Cell Lung Cancer
Adibelimab, Famitinib and Chemotherapy for Advanced NSCLC After PD-1 Inhibitor Failure
This prospective, single-arm trial explores the efficacy of Adibelimab monoclonal antibody combined with Famitinib and chemotherapy in treating locally advanced or metastatic NSCLC patients with negative driver genes who have…
- Trial name
- NCT06336954
- Testing
- Adibelimab
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Severe Acute Respiratory Syndrome Coronavirus 2, Hypoxemic Respiratory Failure
COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia
The purpose of the COVIDNOCHE trial (HFNO versus CPAP Helmet Evaluation in COVID-19 Pneumonia) is to evaluate the comparative effectiveness of standard care non-invasive respiratory support (helmet CPAP versus HFNO) for acute…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Hypoxemic Respiratory Failure, Pneumonia, Viral, COVID
- Trial name
- COVIDNOCHE (NCT04381923)
- Testing
- Helmet Continuous Positive Airway Pressure (CPAP), High Flow Nasal Oxygen (HFNO)
- Where
- United States
- Sponsor
- University of Pennsylvania
Heart Failure Acute, Discharge Follow-up Phone Calls
Congestion and LActate at diScHarge in Acute Heart Failure
Acute heart failure (AHF) is a leading cause of hospitalization and is associated with high short-term morbidity and mortality, with 20-30% of patients experiencing rehospitalization or death within 30 days.
- Conditions
- Heart Failure Acute, Discharge Follow-up Phone Calls, Mortality Prediction
- Trial name
- CLASH-HF (NCT07345156)
- Testing
- Lung Ultrasound Score, Lactate Blood Test
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Weaning Failure
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to…
- Trial name
- NCT07003672
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Heart Failure
B-line by Lung US in Patients With Acute Decompensated Heart Failure
The purpose of this study is to evaluate that B-line detected by lung ultrasound before extubation in patients with acute decompensated heart failure can predict future risk of reintubation and clinical outcomes during admission…
- Trial name
- NCT04322851
- Testing
- Lung ultrasound
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Acute Respiratory Failure
Effects of Body Position and Recruiting Maneuver on Lung Aeration Assessed Through Ultrasound in Patients Intubated for Acute Respiratory Failure Related to Novel Coronavirus 19 Disease
Second analysis of data prospectively collected during an investigation assessing the clinical characteristics of patients admitted for hypoxemic acute respiratory failure (hARF) related to novel coronavirus 19 disease…
- Trial name
- NCT05209477
- Testing
- lung ultrasound assessment
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Azienda Ospedaliera di Perugia
Preterm Infant, BPD - Bronchopulmonary Dysplasia
Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA
Extubation failure is a significant problem in preterm neonates and prolonged intubation is a well-documented risk factor for development of chronic lung disease.
- Conditions
- Preterm Infant, BPD - Bronchopulmonary Dysplasia, Barotrauma
- Trial name
- NCT03242057
- Testing
- NAVA, NIPPV
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Carcinoma, Non-Small-Cell Lung
VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer
The purpose of this study is to evaluate the safety and tolerability of IV administration of VX15/2503 in combination with a fixed dose of avelumab in patients with advanced non-small cell lung cancer.
- Trial name
- CLASSICAL-Lung (NCT03268057)
- Testing
- VX15/2503 + avelumab
- Where
- 11 sites in United States
- Volunteers
- 62 people
- Sponsor
- Vaccinex Inc.
Asthma
Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma
The purpose of the study is to find out if taking vitamin D in addition to an asthma controller medication helps to prevent worsening of asthma symptoms and asthma attacks.
- Trial name
- VIDA (NCT01248065)
- Testing
- Vitamin D3, Ciclesonide
- Where
- 16 sites in United States
- Volunteers
- 408 people
- Sponsor
- Milton S. Hershey Medical Center
Heart Failure, Acute Heart Failure
Inferior Vena CAVA and Lung UltraSound-guided Therapy in Acute Heart Failure
Between 25% and 30% of patients hospitalized for acute heart failure (AHF) are readmitted within 90 days after discharge. Mostly due to persistent congestion on discharge.
- Trial name
- CAVAL US-AHF (NCT04549701)
- Testing
- CAVAL US-guided Therapy, Standard of care
- Where
- 2 sites in Argentina
- Volunteers
- 60 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Hypercapnic Respiratory Failure, Noninvasive Ventilation
Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients
Domiciliary non-invasive ventilation (NIV) is a standard care for improving survival rates of selected patients with chronic hypercapnic respiratory failure (CHRF) and to improve the patients' hypercapnia, sleep quality…
- Trial name
- NCT05008211
- Testing
- Information-Motivation-Behavioral skills (IMB) model-based intervention, Control - usual care
- Where
- Hong Kong
- Volunteers
- 124 people
- Sponsor
- The University of Hong Kong
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