Clinical trials: Pulmonary Infiltrates
Leukemia, Myelocytic, Acute
Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia
The purpose of the study is to determine whether voriconazole is as effective as antifungal prophylaxis in patients undergoing chemotherapy for acute myelogenous leukemia (AML).
- Trial name
- NCT00152594
- Testing
- voriconazole
- Where
- 3 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Cologne
Lung Cancer, Lung Cancer Metastatic
TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Lung Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory lung…
- Conditions
- Lung Cancer, Lung Cancer Metastatic, Lung Cancer, Non-small Cell, Lung Cancer Recurrent
- Trial name
- BAH2472 (NCT06538012)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
PreTerm Neonate, Pulmonary Complications
Effects of Acupressure on Physiological Indicators, Oxygen Demand and Length of Hospital Stay in Premature Infants With Pulmonary Infiltration
In 2020, 11.6% of newborns are delivered prematurely in Taiwan. Excessive sputum is a common symptom of respiratory complications in premature infants.
- Trial name
- NCT07187232
- Testing
- massage acupoints, Routine care
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Community Acquired Pneumonia
Epidemiological Study on Community Acquired Pneumonia
The main objective of this study is to investigate prevalence and risk factors for community-acquired pneumonia (CAP) and its interaction with comorbidities in an unselected group of adult patients receiving outpatient and…
- Trial name
- CAPNETZ (NCT02139163)
- Where
- Germany
- Volunteers
- 20,000 people
- Sponsor
- Capnetz Stiftung
Non Small Cell Lung Cancer
A Phase II Study of GC101 in NSCLC
28 participants are expected to be enrolled for the Phase II clinical trial, this trial is expected to be finished in 36 months.
- Trial name
- NCT07560111
- Testing
- Autologous Tumor Infiltrating Lymphocytes
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Juncell Therapeutics
Cholecystitis, Cholecystitis, Acute
EOIB for Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy, while less painful compared to conventional methods, is still a surgery that can cause significant pain for patients.
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic, Cholecystitis; Gallstone
- Trial name
- NCT06656299
- Testing
- ultrasound guided external oblique intercostal plane block, Bupivacaine injection, paracetamol, tramadol, and ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Breast Cancer, Colorectal Cancer
A Study of TBio-4101 (TIL) and Pembrolizumab in Patients With Advanced Solid Tumors
A multicenter trial to investigate TBio-4101, an autologous, neoantigen-selected, tumor-reactive TIL product, in patients with advanced solid malignancies.
- Conditions
- Breast Cancer, Colorectal Cancer, Uveal Melanoma, Cutaneous Melanoma
- Trial name
- STARLING (NCT05576077)
- Testing
- TBio-4101, Pembrolizumab
- Where
- 13 sites in United States, Canada
- Volunteers
- 31 people
- Sponsor
- Turnstone Biologics, Corp.
Gastric Cancer, Breast Cancer
KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer
This is a phase I clinical trial to determine the maximum tolerated dose (MTD) of KK-LC-1 TCR-T cells for the treatment of metastatic cancers that express KK-LC-1.
- Conditions
- Gastric Cancer, Breast Cancer, Cervical Cancer, Lung Cancer
- Trial name
- NCT05483491
- Testing
- KK-LC-1 TCR-T cells, Aldesleukin
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Christian Hinrichs
Advanced Solid Tumors, Non-Small Cell Lung Cancer
A Study of IOV-5001 in Adults With Advanced Solid Tumors
A Phase 1/2, multicenter, multi-cohort, open-label study of an autologous tumor-infiltrating lymphocytes (TIL) regimen with IOV-5001 in participants with previously treated advanced solid tumors
- Conditions
- Advanced Solid Tumors, Non-Small Cell Lung Cancer, Triple Negative Breast Cancer (TNBC), Colorectal Cancer
- Trial name
- NCT07743723
- Testing
- IOV-5001
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Iovance Biotherapeutics, Inc.
Lung Neoplasms, Tumor Immune Microenvironment
Association of BAL Fluid T-Cell Immune Activity With Tumor PD-L1 Expression and Its Prognostic Value: A Prospective Observational Study
This prospective observational study aims to evaluate whether immune profiles of T-cell subsets in bronchoalveolar lavage fluid can complement tumor PD-L1 expression, assessed by immunohistochemistry in tumor tissue specimens, in…
- Trial name
- NCT07331701
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Melanoma, Non Small Cell Lung Cancer
Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL)
Background: The presence of T-lymphocytes in resected tumor samples derived from long-term survival patients and the fact that reinvigoration of their functionality through the administration of specific immune-therapies can lead…
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Cervical Cancer
- Trial name
- PragmaTIL (NCT06630611)
- Testing
- NMA-LD regimen, Tumor infiltrating lymphocytes adoptive cell therapy (TIL-ACT) infusion, High dose IL-2
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Vall d'Hebron Institute of Oncology
Pulmonary Fibrosis, Interstitial Lung Disease
The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19
This is a collaborative study between Icahn School of Medicine at Mount Sinai, Boehringer Ingelheim Pharmaceuticals and up to 9 other clinical centers across the US to determine the effect of nintedanib on slowing the rate of…
- Conditions
- Pulmonary Fibrosis, Interstitial Lung Disease, Respiratory Disease
- Trial name
- ENDCOV-I (NCT04619680)
- Testing
- Nintedanib
- Where
- 7 sites in United States
- Volunteers
- 103 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
NSCLC
TALENT Study: Phase II Trial of Adjuvant L-TIL Plus Tislelizumab in Resectable NSCLC Without pCR After Neoadjuvant Chemoimmunotherapy
This study evaluates the preliminary efficacy and safety of adjuvant therapy with liquid tumor-infiltrating lymphocytes (L-TIL) in combination with tislelizumab in patients with resectable stage II-IIIB non-small cell lung cancer…
- Trial name
- NCT07330037
- Testing
- L-TIL cells injection, Tislelizumab
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Drug Effect, Rib Fractures
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Rib fractures represent a common injury pattern this is highly associated with patient morbidity and mortality, as pain control remains a challenge.
- Conditions
- Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified
- Trial name
- NCT03305666
- Testing
- Liposomal bupivacaine injection, Bupivacaine indwelling catheter
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Denver Health and Hospital Authority
Bacterial Infections
Effectiveness of Short-Course Versus Standard Antibiotic Therapy in ICU Patients
This study will compare two treatment strategies (standard versus short-course antibiotic therapy) for preventing resistant bacterial infection in patients in the intensive care unit (ICU).
- Trial name
- NCT00410527
- Testing
- Merrem
- Where
- 12 sites in United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Brain Death, Organ Donor
The Effect of Nebulized Albuterol on Donor Oxygenation
The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation…
- Conditions
- Brain Death, Organ Donor, Pulmonary Edema
- Trial name
- NCT00310401
- Testing
- Albuterol, Saline
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Vanderbilt University Medical Center
Pneumonia, Radiographic Lung Infiltrates
Use Of Procalcitonin Level For Guidance of The Treatment of Suspected Community Acquired Pneumonia
The purpose of the study is to learn if a blood test is helpful to the doctors in deciding whether you need antibiotic therapy for possible pneumonia.
- Trial name
- NCT00914550
- Testing
- Procalcitonin level, caregiver informed
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Winthrop University Hospital
Interstitial Lung Diseases
Bronchoalveolar Lavage in Interstitial Lung Diseases to Characterization of Specific Inflammatory Cellular Infiltrate in Different Interstitial Lung Diseases
Interstitial lung disease (ILD) represents a various group of disorders characterized by inflammation and fibrosis within the lung parenchyma.[1] ILD refers to a group of diffuse parenchymal lung disorders, including a spectrum…
- Trial name
- NCT07208201
- Testing
- bronchoscopy
- Volunteers
- 66 people
- Sponsor
- Maha Ahmed Abd EL Gawad Mohammed Okasha
Immune Evasion, Tumor, Neoplastic Cells, Circulating
Immune Mechanisms After Radiofrequency Ablation of Pulmonary Metastases From Colorectal Cancer Origin
Local percutaneous thermal ablation is frequently proposed in the management of metastatic diseases. Radiofrequency ablation (RFA) has demonstrated good results when the metastatic disease is limited and slowly evolving.
- Conditions
- Immune Evasion, Tumor, Neoplastic Cells, Circulating, Circulating Tumor Cell, Pulmonary Metastasis
- Trial name
- ARFIM (NCT03960021)
- Testing
- RFA interventions
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut Bergonié
Surgical Procedures, Operative, Anaesthesia
POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe
International multicenter observational study of a random-sample cohort of patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during a continued 14-day period of recruitment.
- Trial name
- POPULAR (NCT01865513)
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 22,000 people
- Sponsor
- European Society of Anaesthesiology