Clinical trials: Pulmonary Vein Isolation
Atrial Fibrillation, Arrhythmia
Comparison of Rotational Angiography/Electroanatomical Mapping Fusion Versus CT/Electroanatomical Mapping Fusion to Guide AF Ablation
The purpose of this study is to compare rotational angiography (3DATG technology)intra-procedure (during the ablation procedure) with CT (x-ray) pre-procedure (before the ablation procedure) fusion to create an anatomical picture…
- Trial name
- 3DATGvsCT (NCT01537237)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Paroxysmal Atrial Fibrillation
Added Value of Vein of Marshal Ethanol Infusion Compared to Superior Vena Cava Isolation Alone in Patients Undergoing Repeat Ablation for Recurrent Paroxysmal Atrial Fibrillation Despite Durable PV Isolation
The superior vena cava (SVC) is one of the most common non pulmonary vein (PV)-triggers for atrial tachyarrhythmias. SVC electrical isolation can be reached by circular radiofrequency (RF)-ablation under close monitoring of the…
- Trial name
- VEIN-AF (NCT04529785)
- Testing
- SVC only, SVC isolation with substrate modification and vein of Marshal ethanol infusion
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- AZ Sint-Jan AV
Persistent and Long Lasting or Chronic Atrial Fibrillation, Atrial Fibrillation Ablation
SUbstrate Ablation in Persistent Atrial Fibrillation for Elimination of Recurrences (SUPAFER).
Antecedents: electrical isolation of pulmonary veins is the standard treatment for patients with atrial fibrillation. However, its efficacy is lower in persistent and chronic forms of this arrhythmia compared to paroxysmal atrial…
- Conditions
- Persistent and Long Lasting or Chronic Atrial Fibrillation, Atrial Fibrillation Ablation, Linear Left Atrial Ablation, Daily Transtelephonic Electrocardiogram
- Trial name
- SUPAFER (NCT06291506)
- Testing
- Radiofrequency ablation of heart atrial tissue.
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- Hospital Universitario La Paz
Pulmonary Vein Isolation
CLOSE Versus High Density Mapping Guided Catheter Ablation of Paroxysmal Atrial Fibrillation
The aim of this study is to compare two methods of catheter ablation for treatment of paroxysmal atrial fibrillation (AF). The first method being a modified CLOSE protocol used for the control group and the second high density…
- Trial name
- NCT04466358
- Testing
- Modified CLOSE protocol, High density mapping guided pulmonary vein isolation
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation
The Contact PVI Study: Use of Tissue Contact Data to Guide Atrial Fibrillation Ablation
This study aims to investigate the benefit of a new impedance-based computer software application during routine catheter ablation for atrial fibrillation, to see if this information improves short and long term electrical…
- Trial name
- NCT01629056
- Testing
- ablation, RF ablation
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Oxford University Hospitals NHS Trust
Atrial Fibrillation
Multi-electrode PulmonarY Vein Isolation Versus Single Tip Wide Area Catheter Ablation for Paroxysmal Atrial Fibrillation (PAF)
The MYSTIC_PAF trial investigates the differences between treatment with a single-tip catheter against a multielectrode catheter in cardiac ablation procedures in patients with paroxysmal atrial fibrillation.
- Trial name
- MYSTIC-PAF (NCT01696136)
- Testing
- Cardiac ablation for Atrial Fibrillation
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- L.V.A. Boersma
Atrial Fibrillation, Persistent Common Pulmonary Vein
Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)
The investigators studied the effects of adenosine on the reconnection rate after successful pulmonary veins isolation by radiofrequency catheter ablation in patients with drug-resistant atrial fibrillation
- Trial name
- APPLE (NCT01932112)
- Testing
- Adenosine arm
- Where
- South Korea
- Volunteers
- 378 people
- Sponsor
- Yong Seog Oh
Atrial Fibrillation, Congestive Heart Failure
Comparison of Pulmonary Vein Isolation Versus AV Nodal Ablation With Biventricular Pacing for Patients With Atrial Fibrillation With Congestive Heart Failure (PABA CHF)
For patients with atrial fibrillation and heart failure, current treatment can include AV nodal ablation with biventricular pacing.
- Trial name
- PABA CHF (NCT00599976)
- Testing
- Pulmonary vein isolation
- Volunteers
- 81 people
- Sponsor
- Azienda Policlinico Umberto I
Lower Limb Injury, Pulmonary Embolism
Assessment of the Impact of TIP Score on Thromboprophylaxis in Patients With Non-surgical Lower Leg Trauma.
Traumatic lesions are the leading causes of admission to the emergency center (39%), isolated non-surgical lower limbs trauma are in the foreground.
- Conditions
- Lower Limb Injury, Pulmonary Embolism, Venous Thromboses
- Trial name
- EvaTIP (NCT03089255)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Angers
Atrial Fibrillation Chronic, Persistent Atrial Fibrillation
Comparison of Pulmonary Vein Ablation With or Without Left Atrial Posterior Wall Ablation for Persistent AF (PIVoTAL)
The purpose of this study it to learn whether pulmonary vein isolation (PVI) along with ablation of the posterior left atrial wall (PLAW) will reduce the likelihood of atrial fibrillation (AF) recurrence in patients with…
- Trial name
- PIVoTAL (NCT03057548)
- Testing
- Cryo or Radiofrequency (RF) Ablation only of Pulmonary Veins, Cryo or RF Ablation of Pulmonary Veins plus Ablation of the PLAW
- Where
- 2 sites in United States, Japan
- Volunteers
- 110 people
- Sponsor
- Arash Aryana, MD
Paroxysmal Atrial Fibrillation
Added Value of SVC Isolation in Patients With Pulmonary Vein Reconnection Undergoing Repeat Ablation for Recurrent Paroxysmal AF
Redo procedures after CLOSE-guided pulmonary vein isolation (PVI) for atrial fibrillation (AF) occur in 10% of patients. In case of pulmonary vein (PV) reconnection, electrophysiologists may re-isolate the pulmonary veins with or…
- Trial name
- RECONNECT (NCT04602169)
- Testing
- PVI, PVI + SVC
- Where
- Belgium
- Volunteers
- 108 people
- Sponsor
- AZ Sint-Jan AV
Paroxysmal Atrial Fibrillation
CardioFocus vs. Contact Force Guided Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation
The aim of the study is to compare the acute procedure and safety outcomes as well as long term clinical outcomes of 2 groups of patients treated with the HeartLight® Endoscopically Guided Laser Ablation (EGLA) or a commercially…
- Trial name
- CF² (NCT03056222)
- Testing
- Ablation catheter
- Where
- 11 sites in Belgium, Czechia and 2 more
- Volunteers
- 360 people
- Sponsor
- I-Med-Pro GmbH
Atrial Fibrillation (AF), Esophageal Perforation
Esophageal Safety of High and Very High Power Short Duration Pulmonary Vein Isolation: a Randomized Comparison of the 50W and 90W Power Settings
Pulmonary vein isolation (PVI) is the most effective means of maintaining sinus rhythm in atrial fibrillation (AF), while a widely used approach to PVI is point-by-point radiofrequency (RF) catheter ablation.
- Conditions
- Atrial Fibrillation (AF), Esophageal Perforation, Esophageal Perforation, Traumatic
- Trial name
- HPSD-Esophagus (NCT06617442)
- Testing
- Pulmonary vein isolation
- Where
- Hungary
- Volunteers
- 150 people
- Sponsor
- Semmelweis University
Atrial Fibrillation
Pulmonary Vein Isolation With Versus Without Continued Antiarrhythmic Drug Treatment in Subjects With Recurrent Atrial Fibrillation
The purpose of this study is to compare the efficacy and safety of PV isolation with continued antiarrhythmic drug treatment (PVI+ADT) to PV isolation without continued ADT (PVI-ADT) in patients undergoing treatment for…
- Trial name
- POWDER-AF (NCT02475642)
- Testing
- PVI-ADT, PVI+ADT
- Where
- 2 sites in Belgium
- Volunteers
- 152 people
- Sponsor
- VZW Cardiovascular Research Center Aalst
Atrial Fibrillation, Persistent, Atrial Fibrillation Recurrent
A Prospective Study of REPeat Ablation In Patients With Recurrent PERSistent Atrial Fibrillation: Pulmonary Vein Isolation vs. Adjunct Posterior Wall Isolation (REPAIR PERS-AF Study)
This study aims to investigate the best strategy for repeat ablation of recurrent persistent atrial fibrillation (AF) after previous persistent AF ablation involving pulmonary vein isolation (PVI) along.
- Trial name
- REPAIR PERS-AF (NCT06098989)
- Testing
- Radio frequency ablation
- Volunteers
- 150 people
- Sponsor
- Haukeland University Hospital
Atrial Fibrillation, Atrial Fibrillation Ablation
Comparison of Pulmonary Vein Isolation Using SmartTouch® Catheter With or Without Real-time Contact Force Data
The most widely used approach for the invasive treatment of paroxysmal atrial fibrillation is catheter ablation, by which radiofrequency energy is used to heat the tip of an ablation catheter to deliver targeted burns on the…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation Ablation, Pulmonary Vein Isolation
- Trial name
- NCT01730924
- Testing
- Pulmonary vein isolation using contact force sensing catheter
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Queen Mary University of London
Atrial Fibrillation
SMART China, A Multi-center Clinical Registry Study
This is a prospective effectiveness and safety assessment of the study device during radiofrequency (RF) ablation treatment of patients with drug refractory symptomatic atrial fibrillation.
- Trial name
- NCT02485925
- Testing
- THERMOCOOL® SMARTTOUCH™
- Volunteers
- 200 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation (AF)
Safety and Efficacy of Pulmonary Vein Isolation Using Pulsed-field Ablation (PFA) Combined with Either PFA-based Left Atrial Posterior Wall Isolation or Vein of Marshall Ethanol Ablation in Patients with Persistent Atrial Fibrillation
This study is designed to directly compare the safety and efficacy of PFA-based PVI+PWI vs PFA-based PVI+ VoM alcohol ablation in patients with Persistent AF.
- Trial name
- SAVIOR (NCT06878924)
- Volunteers
- 162 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
Continuous Versus Discontinuous Design of Encircling Lesions During Ablation for Atrial Fibrillation
Acute efficacy of point-by-point radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation are comparable independantly of the ablation strategy (continous versus discontinuous ablation) under the…
- Trial name
- CDAF (NCT03332862)
- Testing
- catheter ablation
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Institute for Clinical and Experimental Medicine