Clinical trials: Pulmonary Ventilation Function
Adult Patients of Intensive Care Units on Long-term Lung Mechanical Ventilation
Original Protocol of Oral Cavity Care During Long-term Mechanical Ventilation
This is a prospective open label randomized controlled trial of the efficacy of original oral care protocol for prevention of ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT)in adult…
- Trial name
- NCT05146817
- Testing
- Oral care
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Thoracic Surgical Procedures, One-lung Ventilation (OLV)
Study of Cardiac Power Index During Supine, Lateral, and Between Left and Right Positions During Two- and One-Lung Ventilation (OLV): Comparison of Hemodynamic Changes After Lung Recruitment Maneuver and Fluid Challenge Among Responders and Non-Responders (SVI, MAP, CPI Changes).
The aim of this trial is to study the changes of the Cardiac Power Index (CPI) during supine and lateral decubitus position in two and one lung ventilation respectively.
- Conditions
- Thoracic Surgical Procedures, One-lung Ventilation (OLV), Hemodynamic Changes
- Trial name
- NCT07037225
- Testing
- Fluid challenge during one-lung ventilation (OLV) in the lateral decubitus position, Hemodynamic monitoring
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maria Fountoulaki
Pressure Ulcer, Skin Lesion
Prevention of Skin Damage in the Patient in Prone Position: Development of Education Interventions Based on a Training Needs Assessment Study.
This is study 1 of 3 - of the overall project: The ProneTection Quality Improvement Project. The three aims of this study, study 1 are: 1.
- Conditions
- Pressure Ulcer, Skin Lesion, Acute Respiratory Distress Syndrome
- Trial name
- NCT05238870
- Testing
- Interviews for the needs analysis. No intervention.
- Where
- 2 sites in Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Ghent
Double Lumen Endotracheal Tube, Single Lung Ventilation
VivaSight Double Lumen Tube for Single Lung Ventilation
This prospective, randomized, comparative study is intended to enroll a total of 50 patients undergoing thoracic surgery that necessitates single lung ventilation.
- Trial name
- NCT03690284
- Testing
- Conventional Double Lumen Tube, VivaSight Double Lumen Tube
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pulmonary Atelectasis
Atelectasis Formation: Role of Positive Pressure Breathing, Hyperoxia, and Hypobaria
The primary aim of this project is to get further knowledge of the physiology of flight atelectasis and its prevention. We seek to: 1) assess whether low levels of positive pressure breathing can prevent atelectasis formation in…
- Trial name
- NCT03311347
- Testing
- +Gz accelerations and positive pressure breathing
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Neonatal Respiratory Distress
Transference of Established Simulated Skills (TEST) Trial
This study aims to determine if skills learned in the simulation lab, specifically in managing mask leak during positive pressure ventilation (PPV), translate effectively to the delivery room.
- Trial name
- TEST (NCT06572033)
- Testing
- Simulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Obstructive Pulmonary Disease Exacerbation
Evaluation of Oxygen Delivery Methods in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
To examine the effects of oxygen therapy methods applied as indicated in COPD acute exacerbations on blood gas results and spirometric measurements.
- Trial name
- NCT06561464
- Testing
- EzPAP®, Non-invasive mechanical ventilation (NIMV)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Low Tidal Volume Ventilation
A Feasibility Study of a Low Tidal Volume Ventilation Strategy in One Lung Ventilation
A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.
- Trial name
- NCT03467607
- Testing
- tidal volume ventilation
- Where
- Ireland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Obstructive Sleep Apnea
Right Ventricular Function in Patients With Obstructive Sleep Apnea
The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in right ventricular function evaluated by three dimensional echocardiography.
- Trial name
- NCT01201200
- Where
- Brazil
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate
Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation
Chronic obstructive pulmonary disease (COPD) patients often undergo thoracic surgery due to lung cancer and emphysematous changes.
- Conditions
- Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe, Lungcancer
- Trial name
- NCT02962999
- Testing
- Ketamine, Saline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Ventilation, Breathing
Pilot Evaluation Comparing Regional Distribution of Ventilation During Lung Expansion Therapy
The primary purpose of this study is to determine if there is a significant difference in regional distribution of ventilation when comparing eupneic tidal ventilation with Incentive Spirometry (I.S.) and EzPAP® lung expansion…
- Conditions
- Ventilation, Breathing, Atelectasis
- Trial name
- NCT03083379
- Testing
- Volumetric Incentive Spirometry, EzPAP® POSITIVE AIRWAY PRESSURE
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Neonatal Meconium Aspiration
Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome
Helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．The aim of the study was to assess the effectiveness of synchronize intermittent…
- Trial name
- NCT02620891
- Testing
- helium oxygen mixture
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ma Juan
Respiratory Morbidity, Lung Function Decreased
Mouthpiece With Integrated Cheek Support vs. Manual Cheek Support During Respiratory Oscillometry
The study aims to evaluate the measurement accuracy of respiratory impedance during oscillometry (or Forced Oscillation Technique - FOT) under the following conditions: 1)The subject's cheeks are manually supported by an expert…
- Trial name
- COMICUSROM (NCT06537362)
- Testing
- Mouthpiece with cheek-holder
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Politecnico di Milano
Prematurity; Extreme, Feeding Patterns
To Determine the Best Feeding Practice in Preterm Infants on Non-invasive Ventilation.
To evaluate the duration to reach full feeds by comparing continuous gavage feeds versus bolus feeds in preterm infants who are on non-invasive respiratory support (RAM cannula - short binasal prongs).
- Conditions
- Prematurity; Extreme, Feeding Patterns, Ventilator Lung; Newborn
- Trial name
- NCT05824377
- Testing
- Continuous Feeds, Intermittent Bolus Feeds
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rajeev Kumar
Radiographic Axial Spondyloarthritis
Respiratory Function and S-index in Radiographic Axial Spondyloarthritis
Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory disease that may lead to reduced chest expansion and impaired respiratory function due to thoracic involvement.
- Trial name
- NCT07515131
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gazi University
Respiratory Function Tests, Long COVID
Late Respiratory Consequences of SARS-CoV-2 Pneumonia
The goal of this observational study is to learn about the respiratory system in post-COVID syndrome. The main question aims to answer: how the post-COVID syndrome alters the lung function Participants will be asked to perform…
- Trial name
- NCT05812196
- Testing
- Lung function test, COVID infection
- Where
- Hungary
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Szeged University
COPD, One Lung Ventilation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and hypercapnia may develop.
- Trial name
- NCT02185430
- Testing
- saline infusion, dexmedetomidine infusion
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Chronic Obstructive Pulmonary Disease (COPD)
Upper Airway Morphology and Physiology During Graded Positive Pressure and Nasal High Flow: An MRI Study
This study investigates the effects of graded nasal high flow (NHF) and continuous positive airway pressure (CPAP) on upper airway morphology and respiratory physiology in healthy volunteers and patients with COPD.
- Trial name
- AIR-MRI (NCT07886502)
- Testing
- Nasal High Flow, Continuous Positive Airway Pressure
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Klinikum Dortmund Wirbelsäulenchirurgie
COPD
Dexmeditomedine Versus No Sedation in Management of Agitation in COPD Patients Receiving Noninvasive Ventilation
The aim is to compare sedation using dexmedetomidine to sedation -free approach in management of agitated COPD patients receiving NIV
- Trial name
- NCT05774145
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Respiratory Function
Acute and Long-Term Effects of Integrated Myofascial Release Therapy on Respiratory Function in Healthy Adults
This study will investigate the immediate and longer-term effects of integrated myofascial release therapy on breathing-related outcomes in healthy adults.
- Trial name
- EMGT-RESP (NCT07822139)
- Testing
- Other
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karabuk University