Clinical trials: Pulmonary Ventilation Function
Lung Diseases, Sleep Apnea Syndromes
Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea
The purpose of this study is to determine whether functional status improves in individuals with milder obstructive sleep apnea (OSA) following continuous positive airway pressure (CPAP) treatment.
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Hypertension
- Trial name
- CATNAP (NCT00089752)
- Testing
- Continuous Positive Airway Pressure (CPAP) Treatment
- Where
- 5 sites in United States, Canada
- Volunteers
- 281 people
- Sponsor
- University of Pennsylvania
Endotracheal Tube Wrongly Placed During Anesthetic Procedure, Surgical Procedure, Unspecified
Displacement Between PVC and Silicon DLT
The purpose of this study is to compare difference of displacement between Polyvinyl Chloride(PVC) and Silicon double-lumen endobronchial tubes(DLTs) during changing position from supine to lateral in thoracic surgery.
- Trial name
- NCT02691468
- Testing
- PVC DLT, silicon DLT
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Yeungnam University College of Medicine
Airway Obstruction
Lung Function and Inflammatory Markers in Cement Dust Exposed Workers: A Cross-shifts Study
The aim of the study is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).
- Trial name
- LIS (NCT00727714)
- Where
- Norway
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Sykehuset Telemark
Thoracic Diseases
Ultrasound to Verify Lung-isolation During Single-lung Ventilation
The purpose of the current study is to prospectively evaluate the usefulness of thoracic ultrasonography in demonstrating effective lung isolation during single-lung ventilation (SLV) in the pediatric patient.
- Trial name
- NCT03729999
- Testing
- Portable, Point-of-Care Ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nationwide Children's Hospital
COVID-19
VentaProst in Subjects With COVID-19 Requiring Mechanical Ventilation
The purpose of this study is to investigate whether inhaled epoprostenol given via a breath actuated delivery system will help improve oxygen levels and treatment outcomes in patients with COVID-19 who are on mechanical…
- Trial name
- VPCOVID (NCT04452669)
- Testing
- VentaProst (inhaled epoprostenol delivered via a dedicated delivery system)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Aerogen Pharma Limited
Bacterial Pneumonia
Cefiderocol Concentrations in the Lungs of Hospitalized Patients With Bacterial Pneumonia
The primary purpose of the study is to determine the degree of penetration of cefiderocol into infected lung tissue in hospitalized adults with bacterial pneumonia who are being mechanically ventilated.
- Trial name
- NCT03862040
- Testing
- Cefiderocol, Standard of Care Antibiotic
- Where
- 7 sites in United States
- Volunteers
- 7 people
- Sponsor
- Shionogi
COVID-19
Safety and Efficacy of C21 in Subjects With COVID-19
This is a randomised, double-blind, placebo-controlled phase 2 trial investigating the safety and efficacy of C21 in subjects who are hospitalised with COVID-19 infection, but not in need of mechanical invasive or non-invasive…
- Trial name
- NCT04452435
- Testing
- C21
- Where
- 9 sites in India, United Kingdom
- Volunteers
- 206 people
- Sponsor
- Vicore Pharma AB
COVID-19 Pneumonia, Impaired Respiratory Function
Study of Efficacy and Safety of MAS825 in Patients With COVID-19
This clinical study was designed to assess the efficacy and safety of MAS825 for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infected patients with coronavirus disease 2019 (COVID-19) pneumonia…
- Trial name
- MAS-COVID (NCT04382651)
- Testing
- MAS825, Standard of Care (SoC)
- Where
- 21 sites in United States
- Volunteers
- 140 people
- Sponsor
- Novartis Pharmaceuticals
COPD
Vector Engineering Clinical
This study aimed to validate a novel automatic non-invasive ventilation (NIV) mode that continuously adjusts expiratory positive airway pressure (EPAP) to the lowest value that abolishes tidal expiratory flow limitation (EFL).
- Trial name
- NCT04725500
- Testing
- Auto-Titrating EPAP
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Ventilator Associated Pneumonia, Critically Ill
Efficacy Study on Silver-coated ETT Cleaned With a Novel Device
The purpose of this study is to test the efficacy of a novel cleaning device in keeping silver-coated endotracheal tubes free from bacterial colonization.
- Trial name
- NCT02120001
- Testing
- ETT cleaning maneuver
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
ARDS, Mechanical Ventilation Complication
Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2
The concept of Ventilator-induced Lung Injury Vortex (VILI vortex) has recently been proposed as a progressive lung injury mechanism in which the alveolar stress/strain increases as the ventilable lung "shrinks" (1).
- Conditions
- ARDS, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- VILIVORTEX (NCT04174313)
- Testing
- CT scan
- Where
- Argentina
- Volunteers
- 65 people
- Sponsor
- Hospital El Cruce
Mechanical Ventilation, Single-lung Ventilation
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
The results of this study will help to define the capability and reliability of PulmoVista 500 to detect changes in both global and regional ventilation.
- Conditions
- Mechanical Ventilation, Single-lung Ventilation, ARDS, ALI - Acute Lung Injury
- Trial name
- NCT03076983
- Testing
- Lung Monitoring with EIT device (PulmoVista 500)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Pulmonary Disease, Chronic Obstructive
Ventilator Adapters for Combivent Respimat
The general aim of this 1-day, open label, non-randomised, trial is to characterize the performance of two adapter devices designed to permit use of the Respimat® inhaler with patients requiring mechanical ventilation.
- Trial name
- NCT01969539
- Testing
- Combivent Respimat via tee adapter, Combivent Respimat via ventilator adapter
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Boehringer Ingelheim
Acute Respiratory Failure
Pharmacokinetic Alterations During ECMO
In a healthy patient, the lungs provide oxygen to the blood and remove carbon dioxide. However, in patients with severe lung failure, blood may not adequately be delivered to the lungs, or the lungs may not adequately supply…
- Trial name
- NCT01938079
- Testing
- Ketamine, Sedative drug regimen
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
ARDS, Human, Mechanical Ventilation Complication
Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE
Prone positioning (PP) is an effective first-line intervention to treat moderate-severe acute respiratory distress syndrome (ARDS) patients receiving invasive mechanical ventilation, as it improves gas exchanges and lowers…
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, COVID19
- Trial name
- APPROVE-CARE (NCT04347941)
- Testing
- Prone Positioning, Standard of care.
- Where
- Ireland
- Volunteers
- 24 people
- Sponsor
- University College Hospital Galway
COVID-19, SARS-CoV 2
Canakinumab in Covid-19 Cardiac Injury (The Three C Study)
TThe purpose of this prospective, Phase 2, single center, blinded, randomized controlled study is to demonstrate as a proof of concept that early treatment with canakinumab prevents progressive heart and respiratory failure in…
- Trial name
- NCT04365153
- Testing
- Canakinumab Injection 600mg, Canakinumab Injection 300mg
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Surgery, One-lung Ventilation
Esophageal Pressure Measurements During One-lung Ventilation
The investigators will assess the feasibility and validity of esophageal pressure measurements during one-lung ventilation in the lateral position for surgery by comparing to lung collapse estimated from electrical impedance…
- Trial name
- NCT04725318
- Testing
- One-lung ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Spontaneous Ventilation
EIT Assessment of Lung Volume and Tidal Distribution: A Comparison of Non-Invasive Ventilation Devices
This study is being done to further the investigators' knowledge of the EIT system and to see if measures between two non-invasive ventilation systems routinely used clinically are equivalent.
- Trial name
- NCT02930174
- Testing
- noninvasive positive pressure ventilation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Viral Pneumonia
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection
The goal of this Phase 2 study is to assess the safety, antiviral biomarker responses and efficacy of SNG001 when given to patients requiring invasive mechanical ventilation due to a respiratory virus infection.
- Trial name
- INVENT (NCT06999603)
- Testing
- SNG001
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Synairgen Research Ltd.