Clinical trials: Pulmonary-Related Conditions
Chronic Obstructive Pulmonary Disease
Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline
The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.
- Trial name
- NCT02001935
- Testing
- theophylline
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Zhujiang Hospital
COPD
Brisk Walk on Chronic Obstructive Pulmonary Disease
To determine the effects of 30 min brisk walk on Pulmonary Functions on COPD patients To determine the effects of 30 min brisk walk on Health related Health-related quality of life (HRLQ) on Chronic obstructive pulmonary disease…
- Trial name
- NCT05052047
- Testing
- Brisk Walking Group, Conventional Breathing Exercise Group
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Asthma
Effect of OM-85 BV on Wheezing Related Morbidity in Children With Recurrent Wheezing
The purpose of this study is to determine whether OM-85 BV (Broncho-Vaxom)has any effect on respiratory infections, infection related wheezing attacks, beta-2 agonist use, duration of attacks and effect on serum cytokine levels.
- Trial name
- NCT00733226
- Testing
- OM-85 BV (Broncho-Vaxom)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kecioren Education and Training Hospital
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure
To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Neuromuscular Diseases, Ventilatory Failure
- Trial name
- CRF-QoL (NCT04236726)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
The overlap between chronic obstructive pulmonary disease (COPD) and bronchiectasis is a neglected area of research, and it is not covered by guidelines for clinical practice.
- Conditions
- Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease, Overlap, Microbiome
- Trial name
- NCT04865861
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Cerebral Vein Thrombosis, Deep Vein Thrombosis
Apixaban in Preventing Secondary Cancer Related Venous Thrombosis in Cancer Patients Who Have Completed Anticoagulation Therapy
This randomized phase III trial studies the best dose of apixaban and how well it works in preventing secondary cancer related venous thrombosis in cancer patients who have completed anticoagulation therapy.
- Conditions
- Cerebral Vein Thrombosis, Deep Vein Thrombosis, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT03080883
- Testing
- Apixaban
- Where
- 32 sites in United States
- Volunteers
- 370 people
- Sponsor
- Academic and Community Cancer Research United
COPD (Chronic Obstructive Pulmonary Disease)
Reduced COPD Related Utilization of Healthcare Services and Increased Social Activities by Patients Offered a 24/7 Accessible Telehealth Service Based on the Epital Care Model.
The purpose of this study (The TEMOKAP study) is to investigate whether home-based treatment with telemedicine and support from healthcare professionals can prevent acute exacerbations of COPD and avoid acute hospital admissions…
- Trial name
- TEMOKAP (NCT06988566)
- Testing
- Intervention Group
- Where
- Denmark
- Volunteers
- 184 people
- Sponsor
- ECM Klinikken APS
Metabolic Syndrome, Overweight and Obesity
Age-related Post-lockdown BMI Variations
The COVID-19 lockdown has represented an unedited model of increased metabolic risk in all age groups, due to negative changes in dietary habits, physical activity, lifestyle.
- Trial name
- COVIDLOCKMET01 (NCT05430542)
- Where
- Italy
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Bari
COPD, Lung Diseases
Effect of Indacaterol Maleate in Chronic Obstructive Pulmonary Disease (COPD) on Lung Volume and Related Dyspnea
The purpose of this study is to determine whether indacaterol maleate 300 micrograms (mcg) is effective in the acute treatment of COPD and in particular on reducing lung hyperinflation and dynamic volumes.
- Conditions
- COPD, Lung Diseases, Dyspnea, Hypoxemia
- Trial name
- NCT01377051
- Testing
- Indacaterol maleate
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Milan
Coronary Microvascular Dysfunction, Cardiotoxicity
Effects of Immune Checkpoint Inhibitors on Coronary Microvasculature
This is an observational study that includes patients with breast cancer or non-small cell lung cancer who will be treated with immune checkpoint inhibitor (ICI) therapy.
- Conditions
- Coronary Microvascular Dysfunction, Cardiotoxicity, Breast Cancer, Lung Cancer (NSCLC)
- Trial name
- NCT06332131
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
COPD, CT
Effects of Bronchodilation on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent.
CT studies considering bronchial dimensions in chronic obstructive pulmonary disease (COPD) were conducted without control of bronchodilation.
- Conditions
- COPD, CT, Bronchodilation
- Trial name
- NCT01142531
- Testing
- Chest CT scan
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Erasme University Hospital
Pulmonary Disease, Chronic Obstructive
Observational Study of Adherence to LABA / LAMA in Chronic Obstructive Pulmonary Disease (COPD)
The objective of the study is to observe the effect of adherence to once-daily administered long-acting bronchodilators (long-acting ß2-agonists [LABAs] / long-acting muscarinic antagonists [LAMAs]) on patients health related…
- Trial name
- NCT01937390
- Testing
- Tiotropium 2x2.5µg tiotropium (equivalent to 2x3.154µg tiotropium bromide monohydrate) Respimat® inhaler and cartridge Solution for inhalation, Indacterol 300 µg, Tiotropium 18µg (equivalent to 22.5µg tiotropium bromide monohydrate) HandiHaler® device Inhalation powder, hard capsule
- Where
- Germany
- Volunteers
- 645 people
- Sponsor
- Boehringer Ingelheim
Smoking-related Pathology, Atheroma
Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
Interventional study with minimal risks and constraints, with evaluation of the incidence of lung cancers by low-dose thoracic CT scan without injection of contrast medium, of the immunological, inflammatory and metabolic blood…
- Conditions
- Smoking-related Pathology, Atheroma, Non-progressive Cancer > 5 Years, Lung Cancer
- Trial name
- BIOCEPTION (NCT06387017)
- Testing
- blood sampling, stool collection, low dose CT scan
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Smoking-related Pathology, Atheroma
Structuring of a Lung Cancer Screening Program Including Clinical, Radiological and Biological Phenotyping Useful for the Development of Individualized Risk Prediction Tools: PREVALUNG ETOILE
Patients treated at the Hôpital Nord de Marseille for at least one smoking-related pathology (atheroma, chronic bronchitis, non-progressive cancer > 5 years) or with eligibility criteria for lung cancer screening (inclusion…
- Conditions
- Smoking-related Pathology, Atheroma, Chronic Bronchitis, Non-progressive Cancer > 5 Years
- Trial name
- PREVALUNG* (NCT05649046)
- Testing
- thoracic scan Low dose, BLOOD SAMPLE, FECES SAMPLE
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Artery Disease, Atheroscleroses
Pulmonary Disease in Patients Referred for Coronary CT
Several studies show an association between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD). Besides risk factors such as smoking, both are associated with physical inactivity, advanced age and…
- Conditions
- Coronary Artery Disease, Atheroscleroses, COPD, Respiratory Diseases
- Trial name
- NCT01734629
- Where
- Brazil
- Volunteers
- 205 people
- Sponsor
- University of Sao Paulo General Hospital
Opioid-Induced Constipation
The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
The purpose of this study is to evaluate the safety and efficacy of CB-5945 for the treatment of opioid-induced constipation (OIC) in adults taking opioid therapy for chronic non-cancer pain.
- Trial name
- NCT01901341
- Testing
- CB-5945
- Volunteers
- 44 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Allergic Asthma
Optimization of Asthma Treatment Through Exhaled NO for Increased Asthma-Related Quality of Life (NOAK)
The purpose of this study is to determine whether use of exhaled NO (nitric oxide) to regulate the anti-inflammatory treatment leads to increased asthma-related quality of life in patients with allergic asthma
- Trial name
- NCT00421018
- Testing
- Single corticosteroid inhalers and Singulair
- Where
- Sweden
- Volunteers
- 187 people
- Sponsor
- Karolinska Institutet
Long COVID
Mental Intervention and Nicotinamide Riboside Supplementation in Long Covid
Long COVID, also referred to as post-acute sequela of COVID-19 (PASC), is present in a substantial number of individuals, and treatment for this is warranted.
- Trial name
- MINIRICO (NCT05703074)
- Testing
- Nicotinamide Riboside (NR), Mind-body reprocessing therapy (MBRT), Care as usual
- Where
- Norway
- Volunteers
- 310 people
- Sponsor
- University Hospital, Akershus
Pneumonia, Pneumocystis Carinii, HIV Infections
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4 lymphocytes per mm3.
- Trial name
- NCT00002043
- Testing
- Dapsone
- Where
- United States
- Sponsor
- Jacobus Pharmaceutical