Clinical trials: Pulmonary-Related Conditions
Anxiety, Depression
Meditation-Based Breathing Training in Improving Target Motion Management and Reducing Distress in Patients With Abdominal or Lung Cancer Undergoing Radiation Therapy
This randomized pilot clinical trial studies the effects of meditation-based breathing training on patients' control of their breathing patterns and breathing-related movement, as well as on their psychological distress and…
- Conditions
- Anxiety, Depression, Digestive System Neoplasm, Lung Neoplasm
- Trial name
- NCT01939210
- Testing
- Educational Intervention, Meditation Therapy, Questionnaire Administration
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Albert Einstein College of Medicine
Cystic Fibrosis
Kinetics of YKL-40 Protein in Serum of Cystic Fibrosis Patients
YKL-40 is proposed as a biomarker of various inflammatory disease diabetes and lung disease including cystic fibrosis. In those cross-sectional studies, a unique value of YKL-40 is used to correlate with clinical, physiological…
- Trial name
- Kin_YKL_CF (NCT02305784)
- Where
- Canada
- Volunteers
- 188 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Alpha 1-Antitrypsin Deficiency, Emphysema
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.
The purpose of this study is to investigate the effect of alvelestat (an oral neutrophil elastase inhibitor) on blood and sputum biomarkers in patients with PiZZ, null or rare variant phenotype/genotype alpha-1 anti-trypsin…
- Conditions
- Alpha 1-Antitrypsin Deficiency, Emphysema, COPD
- Trial name
- ASTRAEUS (NCT03636347)
- Testing
- Alvelestat oral tablet - dose 1, Alvelestat oral tablet - dose 2
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 99 people
- Sponsor
- Mereo BioPharma
Cancer, Solid Tumor
Exploring Cancer-Associated Thromboembolism Prognosis Biomarkers and Polymorphisms
This study aims to assess biomarkers and their related polymorphisms in the context of cancer-associated thromboembolism, with a particular focus on their interaction with the immune system.
- Conditions
- Cancer, Solid Tumor, Thromboembolism, Cardiovascular Diseases
- Trial name
- CAT_PB (NCT06065592)
- Testing
- Palbociclib, Rivaroxaban, SNP
- Where
- 2 sites in Lebanon
- Volunteers
- 500 people
- Sponsor
- Lebanese University
Chediak Higashi Syndrome, Chronic Granulomatous Disease
Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders
This study will try to determine what causes learning, behavioral and emotional problems in children with chronic granulomatous disease (GCD) and other phagocyte disorders.
- Conditions
- Chediak Higashi Syndrome, Chronic Granulomatous Disease, Job's Syndrome, Leukocyte Disorder
- Trial name
- NCT00005933
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Sarcopenic Obesity, Chronic Obstructive Pulmonary Diseases
Protein, Sarcopenic Obesity, and COPD
Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults.
- Trial name
- PROSO-COPD (NCT06735573)
- Testing
- the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Aberdeen
Chronic Obstructive Pulmonary Disease, Alpha-1 Antitrypsin Deficiency
Environment Effect on Six-Minute Walk Test Performance
The purpose of this research study is to determine the effect of the environment on six-minute walk test performance in individuals with chronic obstructive pulmonary disease due to alpha-1 antitrypsin deficiency.
- Trial name
- 6MWTAATD (NCT02502201)
- Testing
- six-minute walk study indoors, six-minute walk study outdoors
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Florida
Long COVID, Acute COVID-19
Chronic Stress as a Risk Factor for Long COVID
The disease caused by the pathogen SARS-CoV-2 is known as coronavirus disease with the acronym COVID-19. The acute phase of this condition typically lasts one to two weeks and usually results in a full recovery.
- Trial name
- StressLoC (NCT05652634)
- Where
- Austria
- Volunteers
- 380 people
- Sponsor
- Medical University of Graz
COVID-19, Pain, Chronic
Pain-related Long Covid in Covid-19 Survivors
The exploratory project aims to investigate the presence of pain as a long Covid-19 symptom in previously hospitalised patients and in non-hospitalised persons previously tested positive in a PCR test.
- Trial name
- NCT05520931
- Testing
- Questionnaire and register-based data assessment
- Where
- Denmark
- Volunteers
- 600,000 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Pulmonary Disease, Chronic Obstructive
Physical Exercise and Responses Measured by HIF-1 in COPD
Despite being considered a potentially preventable disease, COPD is classified as one of the respiratory problems with the highest prevalence and socioeconomic impact.
- Trial name
- ECOPDHIF-1 (NCT04955977)
- Testing
- Physical exercise program, Health education in COPD
- Where
- Colombia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Lung Cancer, Advanced Cancer
Acceptance and Commitment Therapy in Patients With Advanced Lung Cancer
Lung cancer is a malignant tumor that has transformed from a single cancer disease into one of the most striking global health problems.
- Trial name
- ACT (NCT04869267)
- Testing
- Acceptance and Commitment Therapy (ACT), Usual care
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Bronchial Epithelial Dysplasia, Chronic Obstructive Pulmonary Disease
Oral Iloprost for the Prevention of Lung Cancer In Former Smokers
This phase II trial tests whether oral iloprost works in preventing lung cancer (chemoprevention) in former smokers. Oral iloprost has previously been shown to reduce abnormal lung cells in former smokers, suggesting a clinically…
- Conditions
- Bronchial Epithelial Dysplasia, Chronic Obstructive Pulmonary Disease, Lung Carcinoma, Stage I Lung Cancer AJCC v8
- Trial name
- NCT05411107
- Testing
- Biospecimen Collection, Bronchial Brush Biopsy, Bronchoscopy
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Locally Advanced Lung Non-Small Cell Carcinoma
Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)
The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy.
- Trial name
- LM (NCT06361784)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Chronic Obstructive Pulmonary Disease
Elastic Tape Relieves Symptoms and Improves Health-related Quality of Life in COPD (Chronic Obstructive Pulmonary Disease)
The goal of this randomized controlled trial is to investigate the effects of elastic tape in individuals with mild to very severe COPD.
- Trial name
- COPD (NCT04415957)
- Testing
- Elastic Tape
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Alpha 1-antitrypsin Deficiency (AATD)
Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction
Brief Summary: This study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests.
- Trial name
- AATD-SAO (NCT07152834)
- Testing
- Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Copd, Smoking Cessation
Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study
Chronic Obstructive Pulmonary Disease (COPD) is caused primarily by smoking and smoking cessation is the first-line treatment for slowing disease progression.
- Conditions
- Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use
- Trial name
- NCT04043728
- Testing
- Unified Protocol adapted for smoking cessation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease
The Short Physical Performance Battery in Chronic Obstructive Pulmonary Disease (COPD)
Patients with COPD often have limitations to physical performance. There are several tests for evaluating physical performance, unfortunately many of them can be time consuming and require specialized equipment an substantial…
- Trial name
- NCT02314338
- Testing
- Pulmonary rehabilitation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- LHL Helse
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Combined Cycle Training and Inspiratory Muscle Training in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) ，the fourth leading cause of death in the world, represents an important public health challenge.
- Trial name
- NCT02200549
- Testing
- Control group, calibrated cycle ergometer, calibrated cycle ergometer and threshold loading device
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhujiang Hospital