Clinical trials: Pulmonology
Biomedical Research
How Participants Perceive Biomedical Research in Pulmonology
The primary objective of this study is to determine how biomedical research is perceived by patients already participating in a pulmonology research project.
- Trial name
- PROTOACCEPT2 (NCT03397056)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study was to investigate the prevalence of chronic bronchitis in patients suffering from moderate to very severe chronic obstructive pulmonary disease (COPD), and to assess the difference in exacerbation rates…
- Trial name
- NCT02128529
- Volunteers
- 976 people
- Sponsor
- AstraZeneca
Silicosis, Pneumoconiosis; Silica
Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma
Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure.
- Trial name
- NCT04205708
- Testing
- Tuberculosis test, Chest X-ray, Pulmonary Function Test
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of Oklahoma
Infection, Lung Parenchyma
Inventory of the Management of Acute Community-acquired Pneumonia in Strasbourg University Hospitals
Acute community-acquired pneumonia (CAP) refers to an acute infection of the lung parenchyma, occurring within the first 48 hours of hospitalization. It is a frequent, serious pathology with a strong economic impact.
- Trial name
- PPAC (NCT05661513)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Strasbourg, France
Pleural Effusion, Heart Failure
Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)
To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).
- Conditions
- Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload
- Trial name
- NCT05797649
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Pulmonary Embolism, D-dimer
Emergency Medicine Pulmonary Embolism Testing Multicentre Study
It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the…
- Conditions
- Pulmonary Embolism, D-dimer, Diagnosis
- Trial name
- EMPET (NCT06320236)
- Testing
- Adjust-Unlikely
- Where
- 4 sites in Canada
- Volunteers
- 4,000 people
- Sponsor
- Dr. Kerstin de Wit
Mechanical Ventilation Complication, Critical Illness
Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis
Antimicrobial treatment could be beneficial in patients with ventilator-associated tracheobronchitis (VAT). The hypothesis of this study is that antibiotic treatment for VAT (3 or 7 days), compared with no antibiotic treatment…
- Trial name
- TAVeM2 (NCT03012360)
- Testing
- ceftriaxone, ciprofloxacin, imipenem
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Lille
Inflammatory Disease, Immune System Disorder
Cross-condition Validation of the Steroid PRO
Testing a questionnaire about treatment with steroids for skin, lung or gastric conditions
- Conditions
- Inflammatory Disease, Immune System Disorder, Gastrointestinal Diseases, Dermatologic Disease
- Trial name
- NCT06314451
- Testing
- Cognitive Interview
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of the West of England
Lung Nodules
A Multicenter, Retrospective, Chart Review Study Evaluating the Impact and Utility of the Blood-Based Proteomic Integrated Classifier and Auto-Antibody Tests in the Real-World
This study is a multicenter retrospective chart review. Sites with at least 100 patients tested with the IC and AAT tests, who have index dates (date of IC and AAT testing) at least one year prior to data collection date will be…
- Trial name
- CLARIFY (NCT06728319)
- Where
- 5 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Biodesix, Inc.
Bronchoscopic Interventions
Single Use Bronchoscopes for Interventional Pulmonology
The goal of this pilot single-arm crossover trial is to investigate the feasibility and safety of using single-use flexible bronchoscopes (SUFB) for routine diagnostic and therapeutic interventional pulmonary procedures instead…
- Trial name
- NCT06596655
- Testing
- Single use bronchoscope
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Respiratory Conditions
Pulmonary Rehabilitation in African Countries
Chronic Respiratory Diseases (CRDs) are common disabling conditions worldwide with high prevalence, morbidity and mortality. More than half of the CRD patients live in low- and middle-income countries (LMICs) where resources for…
- Trial name
- NCT07602673
- Testing
- Centre-based Pulmonary Rehabilitation, Community-based Pulmonary Rehabilitation
- Where
- 3 sites in Cameroon, Nigeria and 1 more
- Volunteers
- 150 people
- Sponsor
- University of Edinburgh
Obstructive Sleep Apnea
Is My Sleep Tracker Tracking my Sleep?
The purpose of this research study is to collect health and physiological data using commercially available wristband fitness tracker devices (FitBit and Garmin devices) to help determine their accuracy and reliability at…
- Trial name
- NCT06174558
- Testing
- Sleep Tracking Devices
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Respiratory Specialists
Dyspnea; Asthmatic, COPD
Diaphragmatic Function as a Biomarker
Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension.
- Conditions
- Dyspnea; Asthmatic, COPD, Fibrosis, Pulmonary Hypertension
- Trial name
- DFUNBIO (NCT05903001)
- Testing
- Diaphragm Ultrasound, Intercostal Muscle Ultrasound, Borg scale
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- RWTH Aachen University
Hospitalization, Smoking
Impact of Twice-daily Measurement of Expired CO During Hospitalization on Smoking
The main objective of this study is to show that the repeated (twice-daily) measurement of expired CO during hospitalization helps reduce smoking.
- Trial name
- CoCHU (NCT03729063)
- Testing
- Twice-daily expired carbon monoxide (CO) measurements, Minimal control
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Montpellier
Lung Cancer
CT-controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Augmented Fluoroscopy Bronchoscopic Navigation Based Diagnostic Yield
In this exploratory adaptive clinical trial the investigators will examine the diagnostic yield of a combination of commercially available imaging and navigation techniques for reaching peripheral lung lesions.
- Trial name
- CONTROL-A (NCT03274609)
- Testing
- Augmented fluoroscopy
- Where
- Netherlands
- Volunteers
- 47 people
- Sponsor
- Radboud University Medical Center
Asthma
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
The main objective of this study is to assess the safety and tolerability of AMG 691 as single doses (healthy participants only) and multiple doses in healthy participants and participants with mild-to-moderate asthma.
- Trial name
- NCT06637371
- Testing
- AMG 691
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Amgen
Inflammatory Disease, Covid19
Evaluation of the Impact of Lock Down and End of Lock Down on the Management of Patients With Inflammatory and Dysimmune Diseases Followed in the Context of IMMINeNT FHU and COVID-19
This questionnaire is distributed via a mailing list (e-mail) of patients treated within the framework of the FHU for pathologies including chronic inflammatory bowel diseases or IBD (Crohn's disease and ulcerative colitis)…
- Trial name
- CONFIMID (NCT04513561)
- Where
- France
- Volunteers
- 921 people
- Sponsor
- University Hospital, Lille
COPD (Chronic Obstructive Pulmonary Disease)
Development And Evaluation of An Adaptive Web-Based Intervention for COPD
Narrative-based tiered asynchronous psychosocial and behavioral whole health support for people adjusting to living with COPD. The intervention is administered by experienced LCSWs under the PI's supervision.
- Trial name
- NCT06770777
- Testing
- Tiered whole health support for people living with COPD
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
COPD, Inactivity, Physical
Actimetry Protocol in COPD Patients
Recently, the principal investigator published an EI predictive Machine Learning algorithm based solely on clinical data, without any physical activity measures, collected from 1 409 patients.
- Trial name
- NCT05918003
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Association pour la Complementarite des Connaissances et des Pratiques de la Pneumologie
Cardiovascular Diseases
Standard vs Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study is an investigator-initiated trial comparing two different catheters (standard versus ultrasound assisted) for the treatment of acute high risk pulmonary embolism (blood clots in lung arteries with evidence or heart…
- Trial name
- NCT03086317
- Testing
- Standard Catheter-Directed Thrombolysis, Ultrasound-Accelerated Thrombolysis
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Emory University