Clinical trials: Pulmonology
Mechanical Ventilation Complication, Critical Illness
Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis
Antimicrobial treatment could be beneficial in patients with ventilator-associated tracheobronchitis (VAT). The hypothesis of this study is that antibiotic treatment for VAT (3 or 7 days), compared with no antibiotic treatment…
- Trial name
- TAVeM2 (NCT03012360)
- Testing
- ceftriaxone, ciprofloxacin, imipenem
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Lille
Respiratory Insufficiency
Contribution of Nasal High Flow in Pneumology Assessed in Acid-Free Hypercapnic Acute Respiratory Failure
The hypothesis is that Nasal High Flow therapy for patients with Hypercapnic Acute Respiratory Failure without acidosis, in addition to standard treatment would improve the care.
- Trial name
- PIRAHNA (NCT06008587)
- Testing
- AIRVO3 TM, Standard therapy
- Where
- 3 sites in France, Monaco
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Pulmonary Medicine, Ventilators, Mechanical
Comparison of Thoracic Vibration With Classical Respiratory Physiotherapy in Patients With Mechanical Ventilation
Inclusion and Exclusion Criteria: Patients aged 18-65 years who are admitted to the investigator's 3rd Stage Intensive Care Unit and are dependent on mechanical ventilation will be included.
- Trial name
- NCT04731532
- Testing
- classical respiratory physiotherapy with thoracic vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Endobronchial Growth, Lung Cancer
Hot and Cold Biopsy Forceps in the Diagnosis of Endobronchial Lesions
A new electrocautery bronchoscopy biopsy forceps is now commercially available and may prevent bleeding following biopsy. Only one study used this device wherein the authors concluded that the use of hot biopsy forceps for…
- Trial name
- NCT00963716
- Testing
- Hot biopsy forceps, Cold biopsy forceps
- Where
- India
- Volunteers
- 168 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COPD
Sarcopenia in COPD Patients: a French Study
The prevalence of sarcopenia is high in many organ pathologies such as COPD, but remains little studied in acute respiratory failure.
- Trial name
- SARCOBS (NCT03111849)
- Testing
- sarcopenia
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Clermont-Ferrand
COPD (Chronic Obstructive Pulmonary Disease)
Development And Evaluation of An Adaptive Web-Based Intervention for COPD
Narrative-based tiered asynchronous psychosocial and behavioral whole health support for people adjusting to living with COPD. The intervention is administered by experienced LCSWs under the PI's supervision.
- Trial name
- NCT06770777
- Testing
- Tiered whole health support for people living with COPD
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Lung Nodules
A Multicenter, Retrospective, Chart Review Study Evaluating the Impact and Utility of the Blood-Based Proteomic Integrated Classifier and Auto-Antibody Tests in the Real-World
This study is a multicenter retrospective chart review. Sites with at least 100 patients tested with the IC and AAT tests, who have index dates (date of IC and AAT testing) at least one year prior to data collection date will be…
- Trial name
- CLARIFY (NCT06728319)
- Where
- 5 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Biodesix, Inc.
Cystic Fibrosis in Children, Chronic Disease
Use of a Connected Companion in Children With Cystic Fibrosis
The study will be conducted over a 6 months period. For the first three months, the child will be accompagned with a connected companion.
- Trial name
- COMPANION-CF (NCT04705636)
- Testing
- Connected device named "Leo" from Ludocare society
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Asthma
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
The main objective of this study is to assess the safety and tolerability of AMG 691 as single doses (healthy participants only) and multiple doses in healthy participants and participants with mild-to-moderate asthma.
- Trial name
- NCT06637371
- Testing
- AMG 691
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Amgen
Mediastinal Lymphadenopathy, Lung Neoplasms
Evaluation of the Utility of Rapid On-site Cytology Performed by an Interventional Pulmonologist During EBUS-TBNA.
This study is a single-centre, prospective observational analysis conducted at the Alessandria Hospital, aimed to evaluating the role of Rapid On-Site Evaluation (ROSE) performed directly by the interventional pulmonologist…
- Trial name
- ROSE (NCT07590947)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Lung Cancer
CT-controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Augmented Fluoroscopy Bronchoscopic Navigation Based Diagnostic Yield
In this exploratory adaptive clinical trial the investigators will examine the diagnostic yield of a combination of commercially available imaging and navigation techniques for reaching peripheral lung lesions.
- Trial name
- CONTROL-A (NCT03274609)
- Testing
- Augmented fluoroscopy
- Where
- Netherlands
- Volunteers
- 47 people
- Sponsor
- Radboud University Medical Center
Bronchoscope Users
Reusable Flexible Bronchoscopes Versus Single Use Bronchoscopes : a Satisfaction Survey
Reusable (RU) flexible bronchoscopes (FB) require intermediate level disinfection operations to prevent transmission of infectious agents from patient to patient.
- Trial name
- NCT03392610
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Limoges
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hospitalization, Smoking
Impact of Twice-daily Measurement of Expired CO During Hospitalization on Smoking
The main objective of this study is to show that the repeated (twice-daily) measurement of expired CO during hospitalization helps reduce smoking.
- Trial name
- CoCHU (NCT03729063)
- Testing
- Twice-daily expired carbon monoxide (CO) measurements, Minimal control
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Montpellier
Down Syndrome
Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France
The purpose of this study is to describe infectious and non-infectious lower respiratory tract diseases in children with Down syndrome followed in pediatric pulmonology consultations in Ile de France.
- Trial name
- ARBT21 (NCT06336577)
- Testing
- lower respiratory tract disease
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Sud Francilien
Lung Cancer
The Role of Interventional Pulmonology, Microbiota and Immune Response in the Patient With Lung Cancer
This study is designed to evaluate complications, specificity, diagnostic yield of radial endobronchial ultrasound guided transbronchial cryobiopsy and transbronchial forceps biopsy with fluoroscopy in the diagnosis of peripheral…
- Trial name
- RIPMIRLC (NCT05164445)
- Testing
- Transbronchial forceps biopsy, Transbronchial forceps biopsy+Transbronchial cryobiopsy
- Where
- Lithuania
- Volunteers
- 200 people
- Sponsor
- Lithuanian University of Health Sciences
COPD, Emphysema
A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema
A Study at Two Hospitals Testing the Safety and Effectiveness of the IAB 50 Flex, a New Implant for Adults with Severe COPD or Emphysema
- Trial name
- IAB-3 (NCT07086339)
- Testing
- Implantable pulmonary stent
- Where
- 2 sites in France, Netherlands
- Volunteers
- 20 people
- Sponsor
- Pulmair Medical, Inc.
Dyspnea; Asthmatic, COPD
Diaphragmatic Function as a Biomarker
Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension.
- Conditions
- Dyspnea; Asthmatic, COPD, Fibrosis, Pulmonary Hypertension
- Trial name
- DFUNBIO (NCT05903001)
- Testing
- Diaphragm Ultrasound, Intercostal Muscle Ultrasound, Borg scale
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- RWTH Aachen University
Cardiovascular Diseases
Standard vs Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study is an investigator-initiated trial comparing two different catheters (standard versus ultrasound assisted) for the treatment of acute high risk pulmonary embolism (blood clots in lung arteries with evidence or heart…
- Trial name
- NCT03086317
- Testing
- Standard Catheter-Directed Thrombolysis, Ultrasound-Accelerated Thrombolysis
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Consulting in Pneumology Department, But Not for Oncology or Tobacology
Criteria Associated With Patient Willingness to Participate in Biomedical Research
The primary objective of this study is to determine the variables associated with patient acceptation or refusal to participate in a clinical research protocol when seen in during a pneumology consultation (excluding oncology and…
- Trial name
- PROTOACCEPT (NCT03098303)
- Where
- 4 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier