Clinical trials: Pulp Necroses
Periapical Lesion, Apical Periodontitis
Effect of Apical Patency on Periapical Lesion Healing
This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth.
- Conditions
- Periapical Lesion, Apical Periodontitis, Dental Pulp Necroses, Mouth Diseases
- Trial name
- NCT07867314
- Testing
- Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Recep Tayyip Erdogan University
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Dental Pulp Necroses, Tooth, Nonvital
Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp Necrosis
This randomized controlled clinical trial evaluated the immediate reduction in intracanal microbial load and the short-term clinical and radiographic progression of anterior primary teeth with pulp necrosis after conventional…
- Trial name
- NCT02485210
- Testing
- Conventional Endodontic Treatment, Antimicrobial Photodynamic Therapy
- Where
- Brazil
- Volunteers
- 7 people
- Sponsor
- University of Nove de Julho
Dental Pulp Necroses
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
- Trial name
- NCT06569329
- Testing
- GentleWave System Root Canal Therapy, EdgePro Laser Root Canal Therapy, The ProUltra Piezo Ultrasonic with EndoUltra Tips Root Canal Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Abhishek Parolia
Pulp Necroses, Apical Periodontitis
"Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"
The aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial.
- Conditions
- Pulp Necroses, Apical Periodontitis, Pulp Disease, Dental
- Trial name
- NCT06129643
- Testing
- Conventional group, Dual laser group, Combined group
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pulp Necroses
Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars
The purpose of this study is to compare the efficacy of GentleWave versus EdgePro irrigation in the disinfection of infected root canals of human permanent teeth with necrotic pulp.
- Trial name
- NCT06554366
- Testing
- GentleWave, EdgePro laser irrigation, Irrisafe passive ultrasonic irrigation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pulp Necroses
Histopathological Evaluation of the Periodontal Ligament Subjected to Laser Ablation.
Laser Ablation therapy (LA) using an 810nm diode laser and Indocyanine Green (ICG) solution, which efficiently absorbs laser energy and increases the effectiveness of tissue removal.
- Trial name
- NCT06173648
- Testing
- Laser and ICG solution.
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CAO Group, Inc.
Pulp Necroses
Assessment of Post-operative Pain After Different Instrumentation Techniques in Pulpectomy Treatment of Primary Molars
The goal of this clinical trial is to compare the post operative pain after using three different instrumentation techniques in pulpectomy treatment of pediatric participant.
- Trial name
- NCT06256250
- Testing
- pulpectomy treatment will be done using the adaptive xp endo shaper., pulpectomy treatment will be done using FANTA AF baby files., pulpectomy treatment will be done using hand k files.
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Pulp Necroses, Apical Periodontitis
Effects of Intracanal Cryotherapy on Endodontic Postoperative Pain
The goal of this clinical trial is to evaluate the effect of cold saline (2.5 degrees Celsius) irrigation on postoperative pain in patients who require root canal treatment in molar teeth because of dead dental pulp and infection…
- Conditions
- Dental Pulp Necroses, Apical Periodontitis, Post Operative Pain
- Trial name
- NCT05611736
- Testing
- cold saline, saline
- Where
- Saudi Arabia
- Volunteers
- 302 people
- Sponsor
- Qassim University
Irreversible Pulpitis, Pulp Necroses
Influence of Moment of Restoration in Pain After a Root Canal Treatment
The goal of this randomized clinical trial is to compare immediate placement of an overlay after root canal treatment with delayed placement of the overlay leaving the tooth one week in infra occlusion.
- Trial name
- NCT06142799
- Testing
- root canal treatment
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Universitat Internacional de Catalunya
Pulp Necroses
Comparison Between Two Regenerative Scaffolds
This study was performed to compare endodontic regeneration outcome in necrotic mature single rooted teeth with periapical radiolucency using platelet rich fibrin (PRF) \& concentrated growth factor (CGF) as a different natural…
- Trial name
- NCT06227533
- Testing
- Endodontic regeneration using concentrated growth factor compared with Platelet rich fibrin
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Pulp and Periapical Tissue Disease, Pulp Necroses
The Efficacy of Laser in Root Canal Disinfection
The aim of this study is to assess in vivo the efficacy of Er,Cr:YSGG/diode laser and Diode/EDTA on bacterial count in root canal treatment in an evidence-based clinical trial.
- Conditions
- Pulp and Periapical Tissue Disease, Pulp Necroses, Pulp; Granuloma
- Trial name
- NCT05964686
- Testing
- Conventional group (NaOCl/EDTA), Dual laser group (Er,Cr:YSGG/Diode):, Combined group (EDTA/Diode):
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Pulp Necroses
Single and Two-visit Pulpectomy in Primary Molars
A total of 64 primary molars of 5-8 years old children will be randomly selected from Pediatric dental clinic at Faculty of Dentistry, Mansoura University.
- Trial name
- NCT06071663
- Testing
- Single and two visits pulpectomy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulp Necroses
The Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization
Dental pulp necrosis is one of the most common pathological conditions that results in tooth loss. However, regeneration of functional dental pulp has proved difficult.
- Trial name
- NCT05728346
- Testing
- Allogeneic human pulp mesenchymal stem cells mixed with hyaluronic acid polymers
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital of Guangzhou Medical University
Primary Teeth, Pulp Necroses
Treatment of Infected Pulp in Primary Teeth With a Mixture of Calcium Hydroxide and Gingerols
This study was conducted to evaluate Calcium Hydroxide mixed with Gingerols versus Metapex in treatment of primary teeth with infected necrotic pulp
- Conditions
- Primary Teeth, Pulp Necroses, Infected Pulp, Root Canal Treatment
- Trial name
- NCT05181813
- Testing
- Ginge-Cal, Metapex
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University
Periapical Diseases, Pulp Necroses
Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)
Conventional endodontic treatment has been the treatment of choice for the management of signs and symptoms of mature permanent teeth with pulpal necrosis and periapical lesion with predictable and favorable results.
- Trial name
- CARETT (NCT05305417)
- Testing
- Autologous Regenerative Endodontic Treatment, Conventional Root Canal Treatment
- Volunteers
- 228 people
- Sponsor
- Universidad de Valparaiso
Pulp Necroses, Tooth, Nonvital
Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry
Aim of the study is to assess canal disinfection using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in single visit and multiple visit regeneration protocols, and to assess clinical…
- Trial name
- NCT04533074
- Testing
- Single-visit regeneration protocol, Multiple-visits regeneration protocol
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Nourhan M.Aly
Pulp Necroses
Zincoxide-propolis vs Zincoxide-eugenol Pulpectomy
The clinical trial aims to evaluate the clinical and radiographic success of Zinc oxide- propolis versus Zinc oxide -Eugenol as obturating material in pulpectomy of non-vital primary teeth.
- Trial name
- NCT05230797
- Testing
- Zinc oxide Propolis, Zinc Oxide-Eugenol Cement
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University