Clinical trials: Pulpal Diseases
Dental Caries
Postoperative Pulpal Complications in Posterior Resin Composite Restorations Without Glass-ionomer Cement Lining
The purpose of this study is to observe the effects of glass-ionomer cement (GIC) lining on risk of pulpal complications in deep occlusal cavities with resin-based restorations.
- Trial name
- NCT01567514
- Testing
- Glass ionomer cement lining
- Where
- Thailand
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Orthodontic Treatment
Curve of Spee: Speed of Leveling Using Different Orthodontic Archwires
The objectives if this study was to evaluate the efficacy of 3 different rectangular archwires in the correction of the curve of Spee (COS), to record the time needed to level excessive COS in the mandibular arch using the 3…
- Trial name
- NCT04549948
- Testing
- 0.017X0.025 Stainless steel, 0.019X0.025 Stainless steel, 0.021X0.025 B-Titanium archwire
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Pulp Exposure
Human Pulpal Response After Pulp Capping With Four Different Agents
Application of four different pulp capping methods on human sound premolars after intentional exposure of the buccal pulp horn through a class one occlusal cavity.
- Trial name
- NCT01468480
- Testing
- Pro Root MTA, Pro Root MTA- single visit, MultiCal
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Pulp Necrosis
Tissue Characterization in Teeth Treated With a Regeneration Protocol
The purpose of the investigators study is to characterize the composition of the hard and soft tissues present in root canals of teeth previously diagnosed with necrotic pulps and incomplete root formation and treated with a…
- Trial name
- NCT00881907
- Testing
- Triple Antibiotic Paste
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pulpitis
Comparative Evaluation of Pulpal Anaesthetic Efficacy of Different Anaesthetic Solutions for Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis
Pulpal and periapical inflammation and infection can cause tissue pH in the affected region to be lowered which results in less penetration of anesthetic solution in the nerve membrane and hence delays the onset of anesthesia.
- Trial name
- NCT05239078
- Testing
- local anaesthetic injection
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr. Vivek Aggarwal
Other Dental Disease/Condition of Teeth/Supporting Structure
Low-cost, Noninvasive Method to Assess Pulpal Vitality
The purpose of this research study is to find a new way of using light to measure the blood flow within the tooth. The researcher develop dental Laser Speckle imaging system tool that can use for exam condition of the tooth.
- Trial name
- NCT02271789
- Testing
- problematic tooth
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Pulpitis, Pulp Inflammation
Comparison of IL-8, FGF-1 and VEGF Levels in Pulpal Tissue, GCF and Dentinal Fluid Samples of Healthy, Reversible and Irreversible Pulpitis Diagnosed Teeth
This study will include 51 patients diagnosed with healthy, reversible and irreversible pulpitis. IL-8, FGF-1 and VEGF levels will be compared using pulpal tissue, gingival crevicular fluid, dentinal fluid samples collected from…
- Conditions
- Pulpitis, Pulp Inflammation, Healthy Pulp, Biomarkers
- Trial name
- NCT06936553
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Apical Periodontitis, Pulp Disease, Dental
In Vivo-Ex Vivo Evaluation of the Root ZX3 for Working-Length Determination
This study evaluates the accuracy and repeatability of the Root ZX3 electronic apex locator for determining root canal working length in single-rooted permanent teeth requiring extraction.
- Trial name
- NCT07689838
- Testing
- Root ZX3 Electronic Apex Locator
- Where
- Saudi Arabia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Pulp Disease, Dental
Efficacy Of Proinflammatory Cytokines in The Primary Molar Pulpotomy
One of the main goals of pediatric dentistry is to preserve the functions and structures of primary teeth until the time of exfoliation. Especially carious lesions are the main factor in the early loss of primary teeth.
- Trial name
- NCT06398327
- Testing
- PULPOTOMY TREATMENT
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Local Anesthetic Drug Adverse Reaction, Local Infiltration
: Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
Anesthetics with vasoconstrictors decrease pulpal blood flow but the impact of intranasal local anesthetics on blood flow is unknown.
- Conditions
- Local Anesthetic Drug Adverse Reaction, Local Infiltration, Pulp Disease, Dental
- Trial name
- NCT03368391
- Testing
- tetracaine HCl and oxymetazoline HCL, 2% Lidocaine with 1:100,000 epinephrine, 3% Mepivacaine with 1:100,000 epinephrine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Tooth Stability, Blood Flow
Effect of Shock Waves on Dental Parameters
This randomized clinical trial investigates the effect of the extracorporeal shockwave therapy (ESWT) on periodontal and endodontical parameters.
- Trial name
- NCT01600118
- Testing
- Extracorporeal shockwave therapy, No extracorporeal shockwave
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dental Anxiety, Pain
Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy
This study aims to compare the effects of computer-controlled local anesthesia and conventional inferior alveolar nerve block on dental anxiety and pain in children undergoing pulpectomy of mandibular primary molars.
- Conditions
- Dental Anxiety, Pain, Pulpal Diseases
- Trial name
- NCT07714915
- Testing
- Computer-Controlled Local Anesthesia, Conventional Inferior Alveolar Nerve Block, Articaine hydrochloride with epinephrine 1:100,000
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Post Operative Pain, Chronic Apical Periodontitis of Pulpal Origin
The Effect of Using Reciprocal Files Alone and With Different Files on Postoperative Pain
This study aims to investigate the effects of using the Wave One Gold file alone and in combination with different files on postoperative pain in patients with asymptomatic apical periodontitis.
- Trial name
- NCT06833515
- Testing
- one flare+wave one gold glider+wave one gold, wave one gold glider+wave one gold, wave one gold
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Harran University
Pulpal Necrosis
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment…
- Trial name
- NCT07210359
- Testing
- human treated dentin matrix hydrogel, Theracal LC - Demineralized dentin matrix combination, Retro Mta
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Endodontic Disease
N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization
Pulp re-vascularization/regeneration is a procedure performed to allow pulpal stem cells to survive and/or differentiate to allow immature tooth root structures to grow to full maturity.
- Trial name
- NAC (NCT03451435)
- Testing
- N acetyl cysteine
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Postoperative Pain
Influence of Apical Patency Concept Upon Postoperative Pain After Root Canal Treatment
The aim of this clinical study is to evaluate the influence of apical patency concept implementation upon postoperative pain following root canal treatment in a single visit approach in molars with pulpal disease.
- Trial name
- patency (NCT05170477)
- Testing
- apical patency, Non-apical surgery
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Effect Of Different Lining Materials in Stepwise Excavation
Deep carious lesions will encounter the dentist with the challenge of selecting a treatment method that could avoid the pulpal exposure and maintain the pulp vitality.Conventional restorative treatments suggest complete removal…
- Trial name
- NCT01730287
- Testing
- Control, Calcium Hydroxide, Mineral Trioxide Aggregate(MTA)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Pulpitis
Effect of Glass Ionomer Cement as an Interim Restoration in Diagnosis of Pulpal Status
Aim: To evaluate whether glass ionomer interim therapeutic restoration (ITR) in asymptomatic teeth with deep cavities can help in determining the pulp status.
- Trial name
- NCT03168620
- Testing
- Restoration
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulpal Necrosis
Single-file Pulpectomy in Primary Molars
The current study evaluates the rotational One Shape single-file system regarding clinical and radiographic outcomes in root canal treatment of infected primary molars.
- Trial name
- NCT04394702
- Testing
- One Shape Single-file rotary system, manual stainless steel K-file
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Minia University