Clinical trials: Pupil
Intravenous Anesthetic Agent Overdose
Interest of a Tetanus Test at a Fixed Remifentanil Concentration Before Laryngoscopy and Skin Incision
Individually-tailored administration of the opioid analgesic component during general anaesthesia is still a challenge for the anesthesiologist.
- Trial name
- NCT02884310
- Testing
- Remifentanil adapted to SPI, Remifentanil fixed
- Volunteers
- 48 people
- Sponsor
- Erasme University Hospital
Cataract
Lidocaine Usage for Pupil Dilatation (Mydriasis)
The purpose of this study is to determine if the mydriatic effect of intracameral lidocaine 1% is as effective as topical cyclopentolate 1% and phenylephrine 10% for achieving effective mydriasis during phacoemulsification…
- Trial name
- NCT01170130
- Testing
- Lidocaine 1% (sterile)
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center
Normal Physiology
Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages.
- Trial name
- NCT05829044
- Testing
- Pupillometry, Light box exposure
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Regional Anesthesia, Horner Syndrome
Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block
The purpose of this study is to assess cerebral blood flow velocity (CBFV) following regional anesthesia for shoulder surgery. The results of this study will help to further understand the physiologic effect of the interscalene…
- Conditions
- Regional Anesthesia, Horner Syndrome, Cerebral Blood Flow
- Trial name
- CBF-TCD (NCT04642612)
- Testing
- TCD Measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pupillary Disorders
Correlation of Pupillary Diameter Changewith Age and Anterior Chamber Depth After Cataract Surgery
PURPOSE: To assess the correlation between the change in pupil diameter, age and depth of the anterior chamber after 3 months of cataract surgery both in photopic and mesopic conditions.
- Trial name
- NCT04286646
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Clinica Oftalmologica TACIR
Autism Spectrum Disorder
Effectiveness of the Autism Pupil Screen (APS) Detect Pupillometer for Identifying Autism Spectrum Disorder (ASD) in Routine Healthcare
Autism spectrum disorder (ASD) is a developmental condition that can affect communication, social interaction, and behavior. Identifying ASD early helps children and families access support services sooner.
- Trial name
- APS001 (NCT07903675)
- Testing
- Autism Pupil Screen (APS) Detect PLR Assessment #1, Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT/R-F), Social Responsiveness Scale, Second Edition (SRS-2)
- Where
- 4 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Schweitzer Engineering Laboratories
Small Pupil, Cataract
Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases
To evaluate the intraoperative stability, safety and overall efficacy of the Canabrava Ring (AJL - SPAIN) when used to expand pupils with less diameter than 5 mm and pupils with sphincter synechiae.
- Trial name
- NCT03206983
- Testing
- Cana's Ring
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Santa Casa de Misericórdia de Belo Horizonte
Aphakia, Mydriasis
Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty
In this study, patients with various causes of pupillary dilatation were recruited, and medical records and ophthalmology examinations, including slit-lamp examination, visual acuity, best corrected visual acuity, intraocular…
- Trial name
- NCT05829122
- Testing
- Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Changzhou Second People's Hospital affiliated with Nanjing Medical University
Vegetative State
The Prognostic Value of Pupil Near Response in UWS Patients
Previous studies suggest that the stimulus of pupil near response (PNR) may be a conscious perception of a blurred image. Moreover, PNR is a reflex that can be objectively observed and with no motor output, suggesting it might be…
- Trial name
- NCT02832492
- Testing
- pupil near response
- Volunteers
- 20 people
- Sponsor
- Wentao Zeng
Nociceptive Pain, Monitoring, Intraoperative
Pain Assessment by Pupil Dilation Reflex (PDR) and Pupillary Pain Index (PPI) in Response to Noxious Stimulation in Anesthetized Adults
After conduction a pilot study, pupillary dilation reflex (PDR) is measured in response to nociceptive stimulation perioperatively.
- Trial name
- NCT03140241
- Testing
- PDR measurement
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- University Hospital, Antwerp
Pain, Monitoring, Intraoperative
Evaluation of the Pupil Dilation Reflex in Response to Noxious Stimulation in Anaesthetized Children. A Proof of Concept Trial
After conduction a pilot study, pupillary dilation reflex (PDR) is measured in response to nociceptive stimulation perioperatively in infants, children and adolescents.
- Trial name
- Pain@OR-kids (NCT03449732)
- Testing
- PDR measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Cataract Surgery
Evaluation of a Protocol of Pupil Dilation Before Laser-assisted Cataract Surgery
Laser-assisted cataract surgery is an innovative and growing procedure to improve the safety and results of modern cataract surgery.
- Trial name
- MYFLACS (NCT03375996)
- Testing
- cyclopentolate 0.5% eye drops
- Where
- France
- Volunteers
- 60 people
- Sponsor
- CHU de Reims
Obesity
Evaluation of California's SB 19 Pupil Nutrition Act
Four California school districts will be randomized to early implementation of California's SB 19 Pupil Nutrition Act or to business as usual.
- Trial name
- NCT00067847
- Testing
- State-directed nutrition policy change
- Where
- United States
- Volunteers
- 5,020 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Intraoperative Floppy Iris Syndrome
Pupil Dilation for Treatment of IFIS
A novel intervention for targeting the treatment of Intraoperative Floppy Iris Syndrome.
- Trial name
- NCT03760185
- Testing
- Brimonidine Tartrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Denver Health and Hospital Authority
Refractive Surgery, Visual Quality
Factors Influencing Nocturnal Symptoms After Refractive Surgery.
By comparing the parameters of the two groups of patients with glare at night after refractive surgery and those without glare at night, the influence of preoperative related parameters on postoperative glare was analyzed.
- Trial name
- NCT05658718
- Testing
- refractive surgery
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Anisocoria
Anisocoria in the Intensive Care Unit (AICU Study)
This retrospective single-center cohort study aims to determine the prevalence of acute "new onset" pupillary abnormalities in adult intensive care unit patients, assess their clinical impact, identify the contexts leading to…
- Trial name
- NCT06964997
- Where
- Switzerland
- Volunteers
- 920 people
- Sponsor
- University Hospital, Basel, Switzerland
Cataract
Topical 0.1% Bromfenac Sodium and Prostaglandin E2 Inhibition in Cataract Surgery
Since a new generation of femtosecond lasers became available for cataract surgery in 2009, the use of this image-guided system has provided several benefits, including a reduction in phacoemulsification energy by…
- Trial name
- NCT02681679
- Testing
- 0.1% bromfenac ophthalmic solution, femtosecond laser cataract surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Glaucoma, Cataract
Outcome of Small Pupil Phacotrabeculectomy in Persons With Glaucoma and Cataract
Small pupils are not uncommon in situations requiring surgical intervention for glaucoma and cataract. Inadequate binocular view during combined trabeculaectomy and glaucoma surgery needs to be overcome by additional iris…
- Trial name
- NCT00434707
- Volunteers
- 70 people
- Sponsor
- Aravind Medical Research Foundation
no Condition, Electroencephalography
Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation
This study investigates the capacity of non-invasive vagus nerve stimulation, applied at the ear, to alter to measures of locus coeruleus output pupil diameter and EEG alpha power.
- Conditions
- no Condition, Electroencephalography, Pupil Diameter
- Trial name
- NCT04455295
- Testing
- Transdermal Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Arkansas Tech University
Opioid Use
Pupillometry-guided Remifentanil Infusion Versus Conventional Administration in Children
Our study aims to compare the total intravenous dose of remifentanil per anesthesia hour and body weight in two groups of pediatric surgical patients - an interventional group with remifentanil infusion under pupillometry…
- Trial name
- PURFT (NCT03749811)
- Testing
- Pupillometry
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital