Clinical trials: Pupil
Pupillary Dilation Effect During Cycloplegic Refraction
Comparing Efficacy and Safety of CTO0303 in Pediatric Subjects
This is a prospective randomized study compared with active control arm.
- Trial name
- NCT06609525
- Testing
- CTO0303-A, CTO0303-B, CTO0303-C
- Where
- South Korea
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Cataract, Mydriasis
Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification
Mydriatic eye drops are routinely used before phacoemulsification but they are not free of drawbacks. Several alternatives were tried to overcome their limitations.
- Conditions
- Cataract, Mydriasis, Adverse Drug Event
- Trial name
- NCT03638726
- Testing
- Atropine sulfate and epinephrine, Topical cyclopentolate and phenylephrine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Dar El Oyoun Hospital
Pupillary Occlusion
Influence of Gaze Shift and Emotions on Symptoms of Blepharospasm
Blepharospasm (BEB) is a focal dystonia characterized by forceful, involuntary contractions of the orbicularis oculi muscle. (Jankovic et al 1983) Patients with BEB report task and situation specific modulations of their…
- Trial name
- NCT01759745
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kirsten Elwischger, MD
Paresis
Pupil-Indexed Noninvasive Neuromodulation
Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning.
- Trial name
- NCT06282406
- Testing
- Transcutaneous Electrical Stimulation
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Peer Group, Parents
Cluster-RCT Collective Nasopharyngeal COVID-19 Testing Amongst Pupils
Does the presence of fellow pupils and parents improves a pupil's resistance to undergo a nasopharyngeaal swab test?
- Trial name
- NCT04993547
- Testing
- Parent and peer presence
- Where
- Belgium
- Volunteers
- 952 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Healthy, Teenager
Effects of Afternoon and Evening Light on Teenagers' Melatonin Levels, Alertness, Sleepiness and Sleep
Many teenagers are familiar with this: on school days, they have to get up early; during the day, they hardly get any light exposure; in the evening, they go to bed late - and are then tired at school the next day! Around the…
- Conditions
- Healthy, Teenager, Healthy Lifestyle
- Trial name
- TeenLight (NCT05483296)
- Testing
- Dim light condition, Moderate light condition, Bright light condition
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Psychiatric Clinics Basel
Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation
Pupillometry and Somatosensory Evoked Potential in Cardiac Arrest
Somatosensory Evoked Potentials (SSEP) and Pupillary Light Reflex (PLR) are key methods for neurologic prognostication in comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation, Resuscitation
- Trial name
- PASCA (NCT04720482)
- Testing
- Somatosensory Evoked Potentials, Automated Pupillometry
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
SARS-CoV-2
Screening for COVID-19 in Teachers, Childcare Educators, Pupils and Preschoolers
The main objectives of this study are 1. to establish the prevalence of SARS-CoV-2 in schools and kindergartens in the State of Mecklenburg-Vorpommern in autumn and winter 2020/2021 2.
- Trial name
- COKITS (NCT04619407)
- Testing
- Nasopharyngeal swab, Serum testing
- Where
- Germany
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Anesthesia, General, Pupil
Pupillometer as a Pain Index During General Anesthesia
This study evaluates the validity of pupil diameter as an indicator of pain during surgery under general anesthesia.
- Conditions
- Anesthesia, General, Pupil, Pain
- Trial name
- NCT04062864
- Testing
- Pupil size
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Preterm Infants
Comparison of Instillation and Packing in Mydriasis for Premature Infants
The purpose of this study is to compare the mydriatic effect of 2.5% phenylephrine and 1% tropicamide by conventional instillation and lower conjunctival fornix packing in premature infants.
- Trial name
- NCT00877175
- Testing
- 1% tropicamide and 2.5% phenylephrine
- Where
- Thailand
- Volunteers
- 25 people
- Sponsor
- Khon Kaen University
Intraocular Lens Replacement
Safety and Efficacy of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification
The purpose of this study is to determine the safety and efficacy of OMS302 (the study drug) for maintaining intraoperative mydriasis in individuals undergoing Intraocular Lens Replacement (ILR) surgery.
- Trial name
- OMS302-ILR-003 (NCT01454063)
- Testing
- OMS302
- Where
- 16 sites in United States
- Volunteers
- 405 people
- Sponsor
- Omeros Corporation
Full Spectrum
A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil
Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by…
- Trial name
- NCT06501131
- Testing
- full-spectrum light exposure, specific spectrum absence light exposure
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia, Visual Diet
Longitudinal Measurements of Visual Diet in Children
Myopia is a leading cause of visual impairment worldwide, with prevalence rising rapidly among children. Growing evidence suggests that environmental and behavioral factors play a dominant role in ocular growth; however, current…
- Conditions
- Myopia, Visual Diet, Pupil, Viewing Distance
- Trial name
- VEET (NCT07642999)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Low Back Pain
Effects of Magnetic Tape on Autonomic Nervous System in Patients With Low Back Pain
The tape will be applied on the lumbar area bilateralemten to the spine without creating any tension. Possible variation in the autonomic nervous system is assessed in the reaction of the pupils.
- Trial name
- NCT04873726
- Testing
- Magnetic Tape® aplication, Kinesiology Tape
- Where
- Spain
- Sponsor
- Francisco Selva
Retinopathy of Prematurity
Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical Trial
The purpose is to assess whether the use of microdrop instillation of phenylephrine 1.67% and tropicamide 0.33% maintains mydriatic efficacy while presents an improved safety profile compared with standard drops of phenylephrine…
- Trial name
- NCT04623684
- Testing
- Microdrop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 6-7 μL)], Standard drop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 28-34 μL)]
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- Aristotle University Of Thessaloniki
Light Sensitivity
Eye Movement Behaviour and Pupil Size in Natural Outdoor and Indoor Scenes
In this study, the researchers will be using eye tracking and detailed lighting measurements to understand how different types of indoor and outdoor lighting affect the eye movements and pupil sizes of our participants.
- Trial name
- NCT05971238
- Testing
- Indoor vs. outdoor scenes
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Parkinson Disease
Assessment of Pupil Light Responses in Patients With Parkinson Disease
Parkinson diseases (PD) is the second most common degenerative disease of the central nervous system. The development of early diagnostic biomarkers may help identify at-risk individuals and allow precocious interventions at the…
- Trial name
- NCT04117555
- Testing
- Pupil response to light stimuli
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Cataract, Postoperative Complications
Validation of an Artificial Intelligence System for Postoperative Management of Cataract Patients
Cataract surgery is the current standard of management for cataract patients, which is typically succeeded by a postoperative follow-up schedule.
- Conditions
- Cataract, Postoperative Complications, Artificial Intelligence
- Trial name
- NCT04138771
- Testing
- An artificial intelligence system for postoperative management of cataract patients
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Emmetropia, Myopia
Effects of Light on the Choroid and Pupil
Monochromatic light creates longitudinal chromatic aberration, with short wavelength blue light forming a focal point in front of the retina and long wavelength red light forming a focal point behind the retina.
- Trial name
- NCT05852782
- Testing
- White Light therapy, Blue light therapy, Red light therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Houston
Management of Intraoperative Floppy-iris Syndrome and Small Pupils With Different Mechanical Devices
Methods to Manage Intra-operative Floppy-iris Syndrome and Poor Pupil Dilation in Cataract Surgery
Cataract surgery is one of the most frequently performed surgeries worldwide and complications are rare. However, there are factors that increase the risk of complications, such as poor pupil dilation and intra-operative floppy…
- Trial name
- IFIS (NCT01778959)
- Testing
- Malyugin Ring, Iris hooks, standard OVD
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery