Clinical trials: Pupillary Response
Myopia
Evaluation of Short Term Use of Experimental Eye Drops BHVI2, 0.02% Atropine and BHVI2 Plus 0.02% Atropine Eye Drops
To assess the one-month ocular effects of nightly application of experimental BHVI2 and 0.02% atropine eye drops either alone or in combination, in children aged between 6 to 13 years old with myopia and randomized to use of…
- Trial name
- NCT03690414
- Testing
- Experimental BHVI2, Atropine sulfate 0.02% eye drops, Combination eye drops
- Where
- Vietnam
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hai Yen Eye Care
Attention Deficit Disorder With Hyperactivity (ADHD), Attention Deficit Disorder (ADD)
A Quick and Reliable Eye Movement Test to Help Diagnose ADHD in Children.
Attention Deficit Hyperactivity Disorder (ADHD) affects more than 5 % of children and adolescents, with a globally increasing prevalence.
- Trial name
- ADHDin15? (NCT07136259)
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Onovis Augenpraxis
Diabetes, Retinal Disorders
Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device)
The basic objective of this project is to test a modification of existing technology for monitoring the responses of the pupil to light as a method for detecting regional losses of function of the retina.
- Trial name
- NCT01546766
- Testing
- Pupillometry testing.
- Where
- 2 sites in United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
General Anesthesia, Intraoperative Awareness
Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia
This prospective observational study will evaluate neuro-mimic indicators of anesthesia depth, including eyelid reflex, eyeball movements, and pupil responses, in patients undergoing elective surgery under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Awareness, Eye Movements
- Trial name
- NCT07199049
- Testing
- Neuro-Mimic Observation Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack
Diagnosis of ON With or Without MS or NMOSD
This is both a prospective and retrospective study of patients with a known diagnosis of optic neuritis (ON) only, multiple sclerosis (MS) with ON, or neuromyelitis spectrum disorder (NMOSD) with ON.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack, Neuromyelitis Optica Spectrum Disorder Relapse, Neuromyelitis Optica Spectrum Disorder Progression
- Trial name
- NCT04131764
- Testing
- Reflex (Brightlamp Inc., Purdue University)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Jagannadha R Avasarala
Chronic Pain, Impaired Pupillary Reflex
Pupil Response in Patients on Opioids.
Evaluation of pupillary reflex in patients on high-dose opioids. Clinical assessment of pain intensity, sedation score, and other side effects of opioids.
- Conditions
- Chronic Pain, Impaired Pupillary Reflex, Opioid-Related Disorders
- Trial name
- Pupillometry (NCT02247024)
- Where
- 2 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Oslo University Hospital
Pain, Monitoring, Intraoperative
Evaluation of the Pupil Dilation Reflex in Response to Noxious Stimulation in Anaesthetized Children. A Proof of Concept Trial
After conduction a pilot study, pupillary dilation reflex (PDR) is measured in response to nociceptive stimulation perioperatively in infants, children and adolescents.
- Trial name
- Pain@OR-kids (NCT03449732)
- Testing
- PDR measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Pupil, Analgesics
Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
The relationship between the target effect site concentration of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus in cardiac surgery during extra corporeal circulation will be…
- Conditions
- Pupil, Analgesics, Opioid Use, Dose-Response Relationship, Drug
- Trial name
- DOLOCEC (NCT03568396)
- Testing
- Pupillometer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Nociceptive Pain, Monitoring, Intraoperative
Pain Assessment by Pupil Dilation Reflex (PDR) and Pupillary Pain Index (PPI) in Response to Noxious Stimulation in Anesthetized Adults
After conduction a pilot study, pupillary dilation reflex (PDR) is measured in response to nociceptive stimulation perioperatively.
- Trial name
- NCT03140241
- Testing
- PDR measurement
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- University Hospital, Antwerp
Pseudotumor Cerebri
Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.
PTC(Pseudotumor cerebri) patients may develop increased Intracranial pressure (ICP) that can produces increased pressure around the distal optic nerve,which is likely followed by venule compression, ischemia, and loss of visual…
- Trial name
- NCT03304314
- Testing
- objective chromatic multifocal pupillometer
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Drug Effect (Glaucoma Drugs)
Pupillary Response After Glaucoma Medication
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
- Trial name
- pupil (NCT02522039)
- Testing
- Latanoprost, Timolol, Dorzolamide
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Hepatic Encephalopathy, Liver Cirrhosis
The Effect of Induced Hyperammonaemia on Sleep and Melanopsin-mediated Pupillary Light Response in Patients With Liver Cirrhosis
Sleep disturbances are common among patients with liver cirrhosis, but the reasons are not well understood. In this project the investigators evaluated whether an increase in blood ammonia in patients with cirrhosis had an impact…
- Conditions
- Hepatic Encephalopathy, Liver Cirrhosis, Sleep Disturbance
- Trial name
- NCT04771104
- Testing
- Amino Acid Challenge (AAC)
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain
Pupillary Response to Incremental Tetanic Stimulations Under Propofol-remifentanil TCI
In patients under standardized steady-state general anesthesia, 6 tetanic stimulations of incremental intensities were applied to the patients. Pupillary dilation in response to these stimulations was recorded.
- Trial name
- NCT04465773
- Testing
- general anesthesia for scheduled gynecological surgery, Propofol, Remifentanil, Ultiva®
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Pr Isabelle CONSTANT
Pupillary Response
taVNS on Pupillary Response and Perceptual Learning
This study has two parts. The study team will evaluate transcutaneous auricular vagal nerve stimulation (taVNS) and two sham settings during a passive task while measuring pupillary response.
- Trial name
- NCT05386563
- Testing
- Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Light Flashing
Effect of Different Color Lights on the Internal Clock and Alertness in Humans
The main aim of this study is to investigate the effects of cone-modulated light emitted from a visual display on human circadian physiology and cognitive performance in the evening.
- Trial name
- CONE (NCT05423002)
- Testing
- Flickering light stimuli, Constant light stimuli, Dim light
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Basel
Caffeine, Alcohol
Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics
The goal of this study is to understand how caffeine and alcohol affect the ocular and physiological systems, especially how the pupil (the aperture in the colored part of the eye) responds to light.
- Conditions
- Caffeine, Alcohol, Pupillary Response, Eye Movements
- Trial name
- PAC (NCT07625358)
- Testing
- Caffeine administration, Alcohol (Ethanol)
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Pain
Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.
- Trial name
- NCT04000126
- Testing
- Pupil reflex dilation measurement (PRD), PPI (Pupillary Pain Index), lidocaine
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury