Clinical trials: Pyothorax
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Complicated Parapneumonic Effusion, Pleural Empyema
Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema
Multicenter, randomized controlled study to compare early mini-invasive thoracoscopy to simple chest tube drainage in complicated parapneumonic effusions or pleural empyema. 100 patients will be recruited.
- Trial name
- NCT00234208
- Testing
- Medical thoracoscopy, Simple chest tube drainage
- Where
- 5 sites in Greece, Italy and 1 more
- Volunteers
- 2 people
- Sponsor
- University Hospital, Basel, Switzerland
Thoracic Diseases, Thoracic Neoplasms
Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.
The goal of this RCT is to compare outcome with McGrath vs Macintosh laryngoscopes among patients undergoing thoracic surgery. The main questions it aims to answer are, 1. Rate of successful intubation at first attempt and 2.
- Conditions
- Thoracic Diseases, Thoracic Neoplasms, Thoracic Empyema
- Trial name
- NCT05988736
- Testing
- MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL)
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Aga Khan University
Pleural Empyema
Dornase Alfa and Urokinase for Kids With Pleural Empyema
The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions
- Trial name
- DUKE (NCT00502632)
- Testing
- Urokinase and Dornase alfa, Urokinase
- Where
- 3 sites in Italy
- Volunteers
- 94 people
- Sponsor
- Azienda Ospedaliera di Padova
Empyema, Pleural
Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children
Despite the improvement in the technology available for diagnosing and treating empyema, the management of empyema in children remains controversial.
- Trial name
- UROVATS (NCT02165891)
- Testing
- insertion of a chest drain with urokinase instillation, primary video-assisted thorascopic surgery
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Queen Fabiola Children's University Hospital
Parapneumonic Effusion, Empyema, Pleural
Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication
This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus…
- Conditions
- Parapneumonic Effusion, Empyema, Pleural, Coagulopathy
- Trial name
- NCT03583931
- Testing
- VATS Decortication, Fibrinolytic Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Denver Health and Hospital Authority
Pleural Empyema
Evaluating Antibiotic Course Upon Adequate Treatment of Empyema
The study compares treatment strategies for treatment of pleural empyema (infected fluid in the chest). It will compare standard of care antibiotic course, 2-6 weeks, to a shorter course of antibiotics, 7 days.
- Trial name
- EvACUATE (NCT07862361)
- Testing
- shortened antibiotic course, Standard medical treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Empyema, Pleural, Thoracic Empyema
Comparison of Lung Expansion After Uniportal and Multiportal Video Assisted Thoracic Surgery for Stage II Post Pneumonic Bacterial Empyema Thoracis
It was a parallel-armed randomized control study in which 160 participants admitted to the Thoracic Surgery Department, Services Hospital, Lahore were included.
- Trial name
- NCT07137507
- Testing
- Uniportal VATS, Multi-portal VATS
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Empyema, Pleural, Parapneumonic Effusion
Management of Pleural Space Infections
Currently, there is no high-quality evidence comparing the clinical outcomes and cost effectiveness of surgical drainage combined with antibiotics versus dual-agent intrapleural fibrinolytic therapy (IPFT) catheter drainage of…
- Trial name
- NCT03873766
- Testing
- Intrapleural Medications, Surgery, Pleural Sampling
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Pleural Infection, Pleural Adhesions
Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion
The purpose of this study is to compare the clinical and radiological efficacy of chemical pleural adhesiolysis (using either intrapleural 3% hydrogen peroxide or intrapleural corticosteroids) versus mechanical pleural…
- Conditions
- Pleural Infection, Pleural Adhesions, Pleural Effusion, Pleural Empyema
- Trial name
- NCT07713329
- Testing
- Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Complicated Pleural Effusion/ Empyema
Efficacy of Fibrinolytic Agents in Complicated Pleural Effusion
Intrapleural administration of fibrinolytic therapy, urokinase in parapneumonic effusion and empyema has been shown to decrease the need for surgical intervention and length of hospital stay.
- Trial name
- NCT03716375
- Testing
- Intrapleural Medications
- Volunteers
- 80 people
- Sponsor
- Beijing Children's Hospital
Empyema, Pleural
Trial of Antiseptic Irrigation for Pleural Infection
Pleural antiseptic irrigation (PAI) is used in conjunction with open drainage for treating adults with chronic post-thoracotomy empyema.
- Trial name
- RINSE (NCT05546762)
- Testing
- Povidone-iodine solution, Normal saline
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Alexandria University
Pneumonia, Necrotizing, Lung Abscess
Complicated Pneumonia (CP) in Children in South-East Europe
This retrospective observational study aims to evaluate clinical course of complicated community acquired pneumonia in children, particularly focusing on necrotizing pneumonia cases, as well as determination of etiological agents…
- Conditions
- Pneumonia, Necrotizing, Lung Abscess, Empyema, Pleural
- Trial name
- CP (NCT06657898)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- Aleksandar Sovtic
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Surgical Complication, COVID-19
The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic Complications
Thoracic complications directly or indirectly consequence of Coronavirus Disease 2019 (COVID-19) (including either pathologies strictly related to the infection, or iatrogenic effects of therapeutic attempts to treat it) have…
- Conditions
- Surgical Complication, COVID-19, Pneumothorax, Empyema, Pleural
- Trial name
- SThor-CoV-2 (NCT05204537)
- Testing
- Lung parenchyma resection, Empyemectomy
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 83 people
- Sponsor
- University of Milano Bicocca
Pleural Effusion, Pneumothorax
Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain
The study will be carried out by the principal investigator and his team at the Division of Cardiovascular and Thoracic Surgery of the Department of Surgery, College of Medicine, University of Ibadan and the University College…
- Conditions
- Pleural Effusion, Pneumothorax, Chest Trauma, Video-assisted Thoracoscopic Surgery
- Trial name
- SUTURE (NCT04193241)
- Testing
- Closure of chest tube wound
- Where
- Nigeria
- Volunteers
- 142 people
- Sponsor
- University of Ibadan
Pleural Empyema, Tuberculosis (TB)
The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront
Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion.
- Conditions
- Pleural Empyema, Tuberculosis (TB), Bacterial Sepsis
- Trial name
- NCT07167823
- Testing
- Decortication
- Where
- Pakistan
- Volunteers
- 350 people
- Sponsor
- University of Health Sciences Lahore
Pyothorax, Fungal Infection Lungs
Fungal Empyema Thoracis
Background: Fungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species.
- Conditions
- Pyothorax, Fungal Infection Lungs, Pleural Empyema
- Trial name
- NCT07337993
- Testing
- pleural lavage followed by surgery, Decortication, Conservative Arm
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Empyema, Pleural
Uniportal VATS Versus Chest Tube for Early Empyema
This randomized controlled study compared uniportal video-assisted thoracoscopic surgery (U-VATS) versus chest tube drainage for initial (first-line) treatment of stage I (exudative) and stage II (fibrinopurulent) empyema in…
- Trial name
- NCT06325904
- Testing
- Uniportal VATS, Tube thoracostomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University