Clinical trials: Pyothorax
Pneumonia, Necrotizing, Lung Abscess
Complicated Pneumonia (CP) in Children in South-East Europe
This retrospective observational study aims to evaluate clinical course of complicated community acquired pneumonia in children, particularly focusing on necrotizing pneumonia cases, as well as determination of etiological agents…
- Conditions
- Pneumonia, Necrotizing, Lung Abscess, Empyema, Pleural
- Trial name
- CP (NCT06657898)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- Aleksandar Sovtic
Pleural Empyema
Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)
Bacterial pneumonia can be complicated by the development of excess fluid and pus (pleural empyema) around the lungs in children. The incidence of pleural empyema in children has increased significantly in the last 10 years.
- Trial name
- NCT01717742
- Testing
- TPA (Tissue Plasminogen Activator), DNase
- Where
- 6 sites in Canada
- Volunteers
- 97 people
- Sponsor
- The Hospital for Sick Children
Pleural Empyema
Evaluating Antibiotic Course Upon Adequate Treatment of Empyema
The study compares treatment strategies for treatment of pleural empyema (infected fluid in the chest). It will compare standard of care antibiotic course, 2-6 weeks, to a shorter course of antibiotics, 7 days.
- Trial name
- EvACUATE (NCT07862361)
- Testing
- shortened antibiotic course, Standard medical treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Empyema, Pleural
Uniportal VATS Versus Chest Tube for Early Empyema
This randomized controlled study compared uniportal video-assisted thoracoscopic surgery (U-VATS) versus chest tube drainage for initial (first-line) treatment of stage I (exudative) and stage II (fibrinopurulent) empyema in…
- Trial name
- NCT06325904
- Testing
- Uniportal VATS, Tube thoracostomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Thoracic Diseases, Thoracic Neoplasms
Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.
The goal of this RCT is to compare outcome with McGrath vs Macintosh laryngoscopes among patients undergoing thoracic surgery. The main questions it aims to answer are, 1. Rate of successful intubation at first attempt and 2.
- Conditions
- Thoracic Diseases, Thoracic Neoplasms, Thoracic Empyema
- Trial name
- NCT05988736
- Testing
- MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL)
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Aga Khan University
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Empyema, Pleural, Thoracic Empyema
Comparison of Lung Expansion After Uniportal and Multiportal Video Assisted Thoracic Surgery for Stage II Post Pneumonic Bacterial Empyema Thoracis
It was a parallel-armed randomized control study in which 160 participants admitted to the Thoracic Surgery Department, Services Hospital, Lahore were included.
- Trial name
- NCT07137507
- Testing
- Uniportal VATS, Multi-portal VATS
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill
Empyema, Pleural, Pleural Effusion
Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
1. Objectives: Main objective: To evaluate the efficacy and safety of intrapleural alteplase vs urokinase in patients with complex complicated parapneumonic pleural effusion and empyema.
- Conditions
- Empyema, Pleural, Pleural Effusion, Pleural Diseases
- Trial name
- NCT01246453
- Testing
- Intrapleurally Alteplase vs Intrapleurally Urokinase
- Where
- 2 sites in Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pleural Effusion, Pneumothorax
Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain
The study will be carried out by the principal investigator and his team at the Division of Cardiovascular and Thoracic Surgery of the Department of Surgery, College of Medicine, University of Ibadan and the University College…
- Conditions
- Pleural Effusion, Pneumothorax, Chest Trauma, Video-assisted Thoracoscopic Surgery
- Trial name
- SUTURE (NCT04193241)
- Testing
- Closure of chest tube wound
- Where
- Nigeria
- Volunteers
- 142 people
- Sponsor
- University of Ibadan
Pleuritis, Pleural Empyema
Procalcitonin in Pleural Pleuritis
The purpose of this study is to determine pleural level of procalcitonin in differents situations of pleuritis.
- Trial name
- NCT01011881
- Testing
- pleural level of procalcitonin
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Surgical Complication, COVID-19
The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic Complications
Thoracic complications directly or indirectly consequence of Coronavirus Disease 2019 (COVID-19) (including either pathologies strictly related to the infection, or iatrogenic effects of therapeutic attempts to treat it) have…
- Conditions
- Surgical Complication, COVID-19, Pneumothorax, Empyema, Pleural
- Trial name
- SThor-CoV-2 (NCT05204537)
- Testing
- Lung parenchyma resection, Empyemectomy
- Where
- 9 sites in United States, Brazil and 3 more
- Volunteers
- 83 people
- Sponsor
- University of Milano Bicocca