Clinical trials: Pyrexia
Tropical Disease
A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru
Tropical diseases are continuously on the rise throughout the world as they are spreading and manifesting in various locations globally.
- Trial name
- NCT03078894
- Testing
- Zika, Chikagunya, Dengue
- Where
- 4 sites in Peru
- Volunteers
- 100 people
- Sponsor
- BioRed LLC
Fever
Treatment Of Fever In The Emergency Department
Fever is a frequent cause of admission to the Emergency Department (ED) around the world. While it can be caused by a wide range of conditions, the most effective treatment based on its etiology is still undetermined.
- Trial name
- NCT05814302
- Testing
- Paracetamol
- Where
- Italy
- Volunteers
- 324 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hemorrhagic Fever With Renal Syndrome
Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines
The purpose of this study is: To assess safety and tolerability of the HTNV and PUUV DNA vaccines, pWRG/HTN-M(x) and pWRG/PUUV-M(s2), administered intramuscularly using a TDS-IM electroporation device Secondary: To evaluate…
- Trial name
- HTNV/PUUV (NCT01502345)
- Testing
- Vaccine/device combination for prevention of HFRS
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Fibromyalgia
Effects of Diatermy in Patients With Fibromyalgia.
Diathermy is a non-invasive pain therapy based on the local application of high-frequency electromagnetic waves. This procedure produces deep heat promotes tissue repair and influences pain sensitivity.
- Trial name
- FIBDIAT (NCT06414369)
- Testing
- Diathermy, Simulated Diathermy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Camilo Jose Cela University
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Marburg Virus Disease
A Study to Evaluate the Single Dose Safety, Tolerability and Pharmacokinetics of IV BCX4430
This is a placebo-controlled, randomized, double-blind study to evaluate the pharmacokinetics of galidesivir following administration of single doses by IV infusion
- Trial name
- NCT03800173
- Testing
- galidesivir
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
Patients With Body Temperature Between 37.8-38.5, No Sign of Infection
Study of Efficacy and Safety of Tinospora Crispa-extract Product Compared With the Acetaminophen
Hypothesis: Tinospora Crispa-extract Product can reduce pyretic similar to acetaminophen. This study aims to investigate the efficacy and safety of Tinospora Crispa-extract product compared with the acetaminophen.
- Conditions
- Patients With Body Temperature Between 37.8-38.5, No Sign of Infection, No Liver and Kidney Problem
- Trial name
- NCT01958866
- Testing
- Tinospora Crispa-extract Product, Acetaminophen
- Where
- Thailand
- Volunteers
- 96 people
- Sponsor
- Chulalongkorn University
NSCLC, Neutropenia
A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Receiving Chemotherapy
Neutropenia is one of the most frequent adverse effects of chemotherapy, and the main factor to limit the dosage and the continuation of chemotherapy.
- Conditions
- NSCLC, Neutropenia, Febrile Neutropenia
- Trial name
- NCT01560195
- Testing
- Pegylated rhG-CSF: 100µg/kg, Pegylated rhG-CSF: 6mg
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Neutropenia, Febrile, Hematologic Cancer
CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients
Patients with blood cancers and those who received a bone marrow transplant frequently have low circulating white blood cell countS.
- Trial name
- CEF-10 (NCT05061654)
- Testing
- Ceftolozane-tazobactam IV
- Where
- Qatar
- Sponsor
- Hamad Medical Corporation
Typhoid Fever
Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children
This study evaluates whether XDR Typhoid fever in children can be effectively treated with monotherapy (meropenum alone), or a combination (meropenum and azithromycin).
- Trial name
- [XDRTYPHOID] (NCT04154722)
- Testing
- Meropenem Injection, Azithromycin Powder
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Ziauddin University
Streptobacillus Moniliformis Infections
Multicenter Retrospective Study on Streptobacillus Moniliformis Infections in France
French data on Streptobacillus moniliformis infections (zoonosis transmitted by rat bites) are rare and there are no case series in the literature to date.
- Trial name
- Streptobacil (NCT06711861)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Dengue, Dengue With Warning Signs
Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients
This study aims to determine the efficacy of montelukast in reducing the incidence of dengue warning signs in adult dengue patients.
- Conditions
- Dengue, Dengue With Warning Signs, Dengue Shock Syndrome
- Trial name
- NCT04673422
- Testing
- Montelukast
- Where
- 4 sites in Thailand
- Volunteers
- 358 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Hyperthermic Intraperitoneal Chemotherapy
A Dose-finding Trial of Hyperthermic Intraperitoneal Docetaxel
This is a single-center study design, and 30 patients will be enrolled. Eligible patients will receive docetaxel at different dose levels according to the trial schedule.All the enrolled patients were treated with docetaxel…
- Trial name
- NCT05410483
- Testing
- Docetaxel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Neutropenia
A Study Comparing Pegylated rhG-CSF and rhG-CSF as Support to Breast Cancer Patients Receiving Chemotherapy
Neutropenia is one of the most frequent adverse effects of chemotherapy, and the main factor to limit the dosage and the continuation of chemotherapy.
- Conditions
- Breast Cancer, Neutropenia, Febrile Neutropenia
- Trial name
- NCT01611051
- Testing
- Drug: Pegylated rhG-CSF: 100µg/kg, Pegylated rhG-CSF: 6mg, rhG-CSF 5ug/kg/day
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Interstitial Cystitis, Painful Bladder Syndrome
Bladder Thermal Distention for Patients With Interstitial Cystitis / Painful Bladder Syndrome
Patients with Interstitial Cystitis / PBS will be treated with bladder thermal distention (BTD).
- Trial name
- IC (NCT01838486)
- Testing
- Bladder Thermal Distention
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Assaf-Harofeh Medical Center
Colchicine Resistant/Intolerant Familial Mediterranean Fever
Evaluate the Safety and Efficacy of Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean Fever (FMF)
A study designed to evaluate the role of treatment with a biological agent - Canakinumab in pediatric (age 4-20) Familial Mediterranean Fever (FMF) patients that are intolerant or resistant for colchicine treatment.
- Trial name
- CONTROL FMF (NCT01148797)
- Testing
- Canakinumab
- Where
- 5 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Novartis Pharmaceuticals
Sarcoma, Alveolar Soft Part Sarcoma
Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas
After a screening, which consists of biopsy, physical examination, initial diffusion-weighted magnetic resonance imaging (DWI-MRI) or body computed tomography (CT) scan, blood tests and case analysis on Multidisciplinary Team…
- Conditions
- Sarcoma, Alveolar Soft Part Sarcoma, Clear Cell Sarcoma, Malignant Peripheral Nerve Sheath Tumors
- Trial name
- SINDIR (NCT03989596)
- Testing
- Hypofractionated radiotherapy, Hyperthermia
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Neutropenic Fever
Antibiotic Stewardship in Suspected Neutropenic Fever (ASTERIC Trial)
Executive Summary Background: Neutropenic Fever (NF), or febrile neutropenia, occurs in patients with early stage and metastatic solid tumours, non-leukaemic haematological cancers and acute leukaemia.
- Trial name
- NCT06794320
- Testing
- NF Protocol, ASTERIC protocol
- Where
- Hong Kong
- Volunteers
- 648 people
- Sponsor
- The University of Hong Kong
Fever
The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine
This study aims to conduct a double-blind, placebo-controlled study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 6 through 47…
- Trial name
- NCT02212990
- Testing
- Acetaminophen Arm, Ibuprofen Arm
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Duke University
Safety Issues
Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever
This is a randomized study to evaluate the safety and feasibility of early de-escalation of empirical antibiotics treatment in neutropenic fever patients undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT04270786
- Testing
- Early de-escalation, Standard
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine