Clinical trials: QTc Interval
Healthy Volunteer
A 2-Part Study to Evaluate the Safety of Supra-Therapeutic Doses of RO4602522 and to Investigate the Effect of RO4602522 on the QTc Interval
This is a 2 part study to evaluate the safety and tolerability of supra-therapeutic doses of RO4602522 (Part A); and to investigate the effect of RO4602522 on the QTcF interval in healthy volunteers (Part B).
- Trial name
- NCT02104648
- Testing
- RO4602522, moxifloxacin
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy Volunteers
A Study To Determine The Effect Of Single-dose PF-04965842 On QTc Interval In Healthy Volunteers Compared With Placebo and Moxifloxacin
This is a Phase 1, single-dose, randomized, 3-treatment, 3-period cross-over, sponsor-open, placebo-and positive-controlled trial to be conducted in approximately 36 adult healthy volunteers.
- Trial name
- NCT03386279
- Testing
- PF-04965842, Moxifloxacin
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers
ADASUVE 2-dose Thorough QT/QTc Study
Assess the potential effects on the QT interval of 2 consecutive doses of ADASUVE administered 2 hours apart, in relation to placebo and an active control in healthy volunteers.
- Trial name
- NCT01854710
- Testing
- ADASUVE 10 mg 2 doses 2 hours apart, Oral moxifloxacin 400 mg
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Healthy
CAEB071 Thorough QTc Study in Healthy Volunteers
This study has been designed in compliance with the ICH-E14 guideline 2005 to evaluate the QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs.
- Trial name
- NCT01594255
- Testing
- sotrastaurin, Avelox
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy
A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants
The purpose of this study is to assess potential effects of enpatoran on cardiac repolarization (i.e. prolongation of QT interval).
- Trial name
- NCT06589726
- Testing
- Moxifloxacin, Enpatoran low dose, Enpatoran high dose
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Postpartum Hemorrhage
A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects
Carbetocin is an oxytocin receptor agonist that selectively binds to receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the…
- Trial name
- NCT05924321
- Testing
- Carbetocin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Healthy Subjects
A QT/QTc Evaluation Study of TS-142 in Healthy Adult Subjects
A clinical study to evaluate the effects on QT/QTc Interval of TS-142 in Healthy Adult Subjects
- Trial name
- NCT04873323
- Testing
- TS-142, Moxifloxacin
- Where
- Japan
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2
Albiglutide Thorough ECG Study in Healthy Volunteers
This study is designed to investigate the effect of treatment with albiglutide on the cardiac repolarization (corrected QT interval) in healthy male and female subjects.
- Trial name
- NCT01406262
- Testing
- Albiglutide, Moxifloxacin
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
A Pharmacokinetic And QT Study Of CP-751,871 In Healthy Subjects
This study is primarily to evaluate the single dose pharmacokinetics of CP-751,871 and its effect on QT interval prolongation.
- Trial name
- NCT00926263
- Testing
- CP-751,871, CP-751,871, moxifloxacin, saline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects
The study is intended to demonstrate that macitentan does not have an effect on cardiac repolarization exceeding the threshold of regulatory concern after repeated administration of daily oral doses of 10 and 30 mg to healthy…
- Trial name
- NCT02050802
- Testing
- Moxifloxacin 400 mg, Macitentan 10 mg, Macitentan 30 mg
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Actelion
Healthy
Clinical Pharmacology of FYU-981 (Effect on QT/QTc Interval)
A Placebo-controlled, Four Way Crossover Study to Investigate the Effect on QT/QTc Interval of a Single Dose of FYU-981, Compared with Placebo, Using Moxifloxacin as a Positive Control, in Healthy Male and Female Volunteers.
- Trial name
- NCT02515864
- Testing
- FYU-981, Moxifloxacin
- Where
- Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fuji Yakuhin Co., Ltd.
Emergence Delirium
The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation
The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval.
- Trial name
- NCT03788564
- Where
- South Korea
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Yonsei University
QT and Corrected QT Intervals Prolongation in HIV Positive Subjects Treated With an Antiretroviral Regimen
Comparison of the QT/QTc Interval Between an Outpatient HIV-Infected Population on Antiretroviral Therapy and Two Large HIV-Negative Cohorts
This is a unicentric, two cohorts, observational transversal study. The purpose of this study is to compare the QT/QTc intervals of HIV positive subjects receiving an antiretroviral therapy and those without HIV in an ambulatory…
- Trial name
- QTVIE (NCT01824628)
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Congestive Heart Failure
Phase I Study of OPC-61815
To investigate the effects of intravenous administration of OPC-61815 at 16 and 32 mg on QT/QTc interval in healthy male subjects
- Trial name
- NCT03510663
- Testing
- OPC-61815 16mg, OPC-61815 32mg, Moxifloxacin
- Where
- Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dyslipidemia
A Thorough Corrected QT Interval Trial
The purpose of this study is to determine the effects of K-877 on ECG parameters with a focus on cardiac repolarization compared with placebo in healthy adult subjects.
- Trial name
- NCT02073084
- Testing
- K-877 Low Dose, Moxifloxacin, K-877 High Dose
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Healthy Volunteer
Study Developed to Evaluate the Effect of ANG-3777 on QT/QTc Interval
The purpose of this study is to evaluate the effect of ANG-3777 on placebo-corrected change from baseline, QT/corrected QT (QTc) interval, following single intravenous (IV) doses in healthy volunteer adults.
- Trial name
- NCT04898907
- Testing
- ANG-3777 (Therapeutic Dose), ANG-3777 (Supra-therapeutic Dose), Moxifloxacin Hydrochloride
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Angion Biomedica Corp
Acute Myeloid Leukemia With FLT3/ITD Mutation
A Study to Evaluate the Effect of XY0206 on the QTc Interval in Chinese Healthy Participants
This study plans to enroll 45 (Groups A, B, and C) to 75 healthy participants (including the sample size of other potential dose groups). The participants will be divided into three dose groups: 37.5 mg, 75 mg, and 150 mg.
- Trial name
- XY0206-CQT (NCT07162116)
- Testing
- XY0206, Moxifloxacin (400 mg)
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Healthy Volunteer
A Two-part, Single-dose, Randomized Study to Evaluate the Safety of Supra-therapeutic Doses of RO7033877 and to Investigate the Effect of RO7033877 on the QTc Interval
This is a two-part study to evaluate the safety and tolerability of supratherapeutic doses of RO7033877 (Part 1) and to investigate the effect of RO7033877 on the QTc interval in healthy volunteers (Part 2).
- Trial name
- NCT02165332
- Testing
- Part 1: SAD RO7033877, Part 2: Treatment A, RO7033877, Part 2: Treatment B, RO7033877
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
QTc Interval, Pharmacokinetics
An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's Pharmacokinetics
This study is comprised of two parts. The purpose of the first part of this study is to evaluate the effects of a supratherapeutic dose of psilocybin on cardiac repolarization.
- Trial name
- NCT05478278
- Testing
- Psilocybin, Moxifloxacin, Micro-Crystalline Cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Usona Institute
Influenza, Human
A Study to Evaluate the Effect of Intravenous Zanamivir on Cardiac Conduction in Healthy Volunteers
Approximately 40 healthy subjects will be enrolled. Each subject will participate in the study for approximately 9 weeks. There will be four treatment sequences with a 5-7 day washout between treatments.
- Trial name
- NCT01353729
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline