Clinical trials: QTc Interval
Healthy
Evaluation of the Effect of ATX-101 on QT/QTc Intervals
To evaluate the effect of maximum therapeutic and supratherapeutic doses of ATX-101 treatment on Fridericia's corrected QT interval (QTcF).
- Trial name
- ATX-101-11-24 (NCT01706679)
- Testing
- ATX-101 (10 mg/ml), ATX-101 (20 mg/ml), Moxifloxacin (400 mg)
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Healthy Subjects
Evaluate the Effect of TPN171H on the QT/QTc Interval in Healthy Volunteers
This is a single-dose orally administered, dose-escalation, single-center, randomized, double-blind, placebo-parallel controlled clinical study evaluating the effect of TPN171H tablets on QT/QTc interval in healthy subjects.The…
- Trial name
- NCT05750355
- Testing
- TPN171H 10 mg Group, TPN171H 30 mg Group, TPN171H 40 mg Group
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Qt Interval, Variation in
Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects
The purpose of this study is to assess the effect of a single therapeutic dose and a single supra-therapeutic dose of imeglimin on the QT/QTc interval
- Trial name
- NCT02924337
- Testing
- Imeglimin, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Poxel SA
QTc Interval
Post-Exercise Cardiovascular Responses Following Energy Drink Consumption
The purpose of this study is to determine the effects of consuming an original flavor energy drink on electrocardiographic (ECG) and hemodynamic responses during and after exercise in healthy subjects.
- Trial name
- NCT03418077
- Testing
- Energy Drink
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Healthy Volunteers
Guanfacine Immediate-release Electrocardiogram Results (QTc) Study
To assess the effect of immediate-release guanfacine hydrochloride, administered at therapeutic and supratherapeutic doses, on QT/QTc in healthy normal males and females
- Trial name
- NCT00672984
- Testing
- immediate release guanfacine hydrochloride, moxifloxacin
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Shire
Cough, Endometriosis
Study to Gather Information on the Influence of BAY1817080 on the Electrical Activity of the Heart Recorded by an Electrocardiogram in Healthy Male and Female Participants
In this study, researchers want to find whether the study drug BAY1817080 has an effect on the electrocardiogram (ECG). 40 healthy male or female participants with the age of 18 to 65 years will be enrolled into this study.
- Conditions
- Cough, Endometriosis, Overactive Bladder
- Trial name
- NCT04423744
- Testing
- BAY1817080, Moxifloxacin
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy Volunteer
A Study to Investigate the Effect of GDC-0449 on the QT/QTc Interval in Healthy Female Subjects
This is a Phase I, single-center, three-arm, randomized, double-blind, active- and placebo-controlled study to investigate the effect of GDC-0449 on the QT/QTc interval in healthy female subjects of non-childbearing potential.
- Trial name
- NCT01173536
- Testing
- GDC-0449, moxifloxacin
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Dyslipidemia
A Thorough Corrected QT Interval Trial
The purpose of this study is to determine the effects of K-877 on ECG parameters with a focus on cardiac repolarization compared with placebo in healthy adult subjects.
- Trial name
- NCT02073084
- Testing
- K-877 Low Dose, Moxifloxacin, K-877 High Dose
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
ADPKD (Autosomal Dominant Polycystic Kidney Disease)
A Study to Investigate the Effects of JMKX003142 on QTc Interval in Healthy Adults
The primary objective of this study is to assess the effect of a therapeutic and supratherapeutic oral dose of JMKX003142 on the corrected cardiac QT interval relative to a placebo in healthy participants
- Trial name
- NCT07470177
- Testing
- JMKX003142 tablets
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jemincare
Effects of Sativex on ECG
Sativex Thorough QT/QTc Study
This study was to evaluate effects of Sativex on electrocardiogram (ECG) traces when administered at its therapeutic dose of 8 sprays per day and at multiples of the therapeutic dose (24 or 36 sprays per day), and to evaluate its…
- Trial name
- NCT01322139
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Healthy Participants
A Study to Investigate the Effect on QTcF of Baxdrostat Compared With Placebo, Using Moxifloxacin as a Positive Control, in Healthy Participants
This study will assess the effect of single oral doses of baxdrostat on the ECG interval measured from the onset of the QRS complex to the end of the T wave (QT) interval corrected for HR using Fridericia's formula (QTcF)…
- Trial name
- NCT06194032
- Testing
- Baxdrostat, Moxifloxacin
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants
The purpose of this study is to determine the safety, tolerability, and pharmacokinetics (PK) of high dose of BMS-986278 in healthy participants and to assess the effect of BMS-986278 on the ECG intervals in healthy participants.
- Trial name
- NCT06746402
- Testing
- BMS-986278, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Tuberculosis
Effects of SQ109 on QTc Interval in Healthy Subjects
This will be a single center, open label, crossover study to evaluate the safety and tolerability of multiple dose levels of SQ109.
- Trial name
- NCT01874314
- Testing
- SQ109, Moxifloxacin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
QTc Evaluation, Electrocardiography
Influence of Moxifloxacin on QTc Interval in Healthy Subjects for Positive Control Validation
The aim of this study is to investigate the effect of moxifloxacin on the QT interval in order to gain information on the validity of results that will be collected during another clinical study testing riociguat in patients with…
- Trial name
- NCT01014247
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 6 sites in Australia, Germany and 2 more
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
A Study to Assess Electrocardiogram Results in Healthy Volunteers Receiving Canagliflozin (JNJ-28431754)
The purpose of this study is to assess the effect of canagliflozin (JNJ-28431754) on electrocardiogram results (recordings of the electrical activity of the heart) in healthy volunteers after a single therapeutic dose (300 mg)…
- Trial name
- NCT01787357
- Testing
- Canagliflozin (JNJ-28431754), Moxifloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cardiometabolic Risk Factors
Heart Focused Movement Effects on Cardiometabolic Risk
This study is designed as a two-group parallel randomized controlled trial (N=50) to test effects of 8-weeks of Qigong/Tai Chi (QTC) intervention compared to QTC plus HRVB on HRV parameters (primary), and cardiometabolic risk…
- Trial name
- NCT05687240
- Testing
- Qigong/Tai Chi, Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Fibromyalgia
Phase 1 Thorough QT (TQT) Study in Young Healthy Volunteers
This Phase 1 study will assess the effects of esreboxetine on the heart. In particular the effects on a specific electrocardiogram (ECG) measurement called QTc will be measured.
- Trial name
- TQT (NCT00809289)
- Testing
- esreboxetine, moxifloxacin
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Prolonged QTc Interval, Pharmacokinetic
Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healthy Men and Women
The effect of multiple oral administration of two doses of CG5503 PR (prolonged release) compared to placebo on the electrical activity of the heart were investigated.
- Trial name
- NCT03951402
- Testing
- 100 mg CG5503 (tapentadol hydrochloride) PR tablet, 400 mg Moxifloxacin tablet (overencapsulated)
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Healthy Volunteers
A Study to Investigate the Safety, Tolerability, and Drug Levels of BMS-986419 (Part 1) and the Effects Multiple Doses of BMS-986419 on Cardiac Repolarization (Part 2) in Healthy Participants
The purpose of this study is to investigate the safety, tolerability, and pharmacokinetics of BMS-986419 (Part 1) and the effects of multiple doses of BMS-986419 on cardiac repolarization (Part 2) in healthy participants.
- Trial name
- NCT06846866
- Testing
- BMS-986419, Moxifloxacin
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy
Effect of Anagrelide Hydrochloride on Any Changes in Heart Function in Healthy Volunteers
According to the ICH Guidance Document E14, all non-antiarrhythmic drugs should be evaluated for their ability to prolong the QT interval which represents the duration of ventricular depolarization and subsequent repolarization.
- Trial name
- NCT01552928
- Testing
- Anagrelide 0.5 mg, Anagrelide 2.5 mg, Moxifloxacin
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shire