Clinical trials: Qt Interval, Variation in
Qt Interval, Variation in
Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers
The study designed to determine the effect induced by WCK 2349 on the QT interval. The study will be conducted in two parts: 1) to determine the supratherapeutic dose; and 2) to assess the safety of high doses of single-dose…
- Trial name
- NCT02217930
- Testing
- WCK 2349, Moxifloxacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wockhardt
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev
Qt Interval, Variation in, Adverse Effect of Selective Serotonin Reuptake Inhibitors
Effect of Antenatal SSRI Exposure on the QT Interval of Neonates
Selective Serotonin Reuptake Inhibitors (SSRIs) are a group of antidepressants that suppress the re-absorption of a chemical called Serotonin in the brain, and improve mood.
- Trial name
- SSRIs (NCT02492347)
- Testing
- Electrocardiogram
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Southampton
COVID, Arrhythmia
COVIDAR - Arrhythmias in COVID-19
BACKGROUND AND RATIONALE: There is very limited literature available on the arrhythmia occurrence in the context of an infection by the SARS-CoV2 virus.
- Conditions
- COVID, Arrhythmia, Torsades de Pointe Caused by Drug, Qt Interval, Variation in
- Trial name
- COVIDAR (NCT04437901)
- Where
- 5 sites in Belgium, Italy and 3 more
- Volunteers
- 10,000 people
- Sponsor
- Hospital Clinic of Barcelona
Qt Interval, Variation in
Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects
The purpose of this study is to assess the effect of a single therapeutic dose and a single supra-therapeutic dose of imeglimin on the QT/QTc interval
- Trial name
- NCT02924337
- Testing
- Imeglimin, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Poxel SA
Cardiac Arrhythmia, Qt Interval, Variation in
Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients
This study will validate the recording accuracy of a specific electrical interval of the heart, the QT interval, between an iPhone rhythm strip recording and a traditional 12-lead electrocardiogram (ECG).
- Trial name
- NCT02241252
- Testing
- iPhone ECG
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Qt Interval, Variation in
Exercise Induced QT Interval Changes in Response to Intermittent and Continuous Graded Exercise Tests
Long QT syndrome (LQTS) is an inherited heart defect where the heart takes longer to recover between beats. LQTS is a known condition predisposing young footballers to sudden cardiac death (SDC).
- Trial name
- NCT04005027
- Testing
- Intermittent graded exercise test
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sunderland
Cardiac Transplant Rejection, Qt Interval, Variation in
Home Electrocardiogram (ECG) Monitoring After Heart Transplantation
The long-term goal of this research is to apply novel technology for detection of donor organ (allograft) rejection to improve patient outcomes following heart transplantation.
- Trial name
- NEW HEART (NCT01365806)
- Where
- 3 sites in United States
- Volunteers
- 345 people
- Sponsor
- University of California, Los Angeles
Qt Interval, Variation in
The Effect of Anesthetic Agents Management on ECG Changes of Patients Who Were Operated Under RIVA
IVRA can be performed with many local anesthetics and adjuvant agents. Investigators planned to compare cardiac effects and ECG changes by IVRA with lidocaine and lidocaine plus ketamine.
- Trial name
- NCT02063620
- Testing
- Ketamine HCL
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Torsades de Pointe Caused by Drug (Disorder), Torsades de Pointes
Pharmacist Use of ECG to Inform Drug Therapy Decisions for Patients Receiving QT Prolonging Medications
Torsade de pointes (TdP) is a cardiac arrhythmia associated with QT interval prolongation which may lead to cardiac arrest. Prescription medications which cause QT interval prolongation are commonly used in daily practice.
- Conditions
- Torsades de Pointe Caused by Drug (Disorder), Torsades de Pointes, Qt Interval, Variation in
- Trial name
- NCT04000542
- Testing
- Pharmacist Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northeast Iowa Medical Education Foundation
Qt Interval, Variation in
Clinical Study to Evaluate Effect on QT/QTc Interval After Multiple Dose of Celecoxib
This study is conducted to evaluate effect on QT/QTc Interval after multiple dose of celecoxib among healthy adult volunteers. It is randomized, open-label, negative and postive control, and crossover study.
- Trial name
- NCT03822520
- Testing
- Celecoxib, Moxifloxacin, Water
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
QT Interval, Variation in
Clinical Trial of the Effect of Methoxyethyl Etomidate Hydrochloride on the QT Interval of the Heart
A single intravenous injection of 0.8mg/kg or 2.8mg/kg Et-26-hcl was given to 18 subjects. The effect of plasma concentration on QT interval was evaluated by C-QTc effect model, and the pharmacokinetic characteristics and safety…
- Trial name
- NCT06822153
- Testing
- ET-26 0.8mg/kg(low-dose) group, ET-26 2.8mg/kg(high dose) group
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Diabetes Type 2, Hyperglycaemia (Diabetic)
Effect of Hyperglycaemia and Moxifloxacin on QTc Interval in T2DM
Diabetes is a significant risk factor for sudden cardiac death, with the QTc interval on electrocardiograms (ECGs) often prolonged in diabetic patients due to factors such as hyperglycaemia and insulin resistance.
- Conditions
- Diabetes Type 2, Hyperglycaemia (Diabetic), QT Interval, Variation in, Torsades de Pointes
- Trial name
- NCT07014735
- Testing
- glucose, moxifloxacin
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Richmond Pharmacology Limited
E Cigarette Use, Vaping
Acute Effects of TCIG vs ECIG in PLWH
Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization and inflammation/oxidative stress.
- Conditions
- E Cigarette Use, Vaping, Smoking, Tobacco Smoking
- Trial name
- NCT04568395
- Testing
- TCIG, ECIG
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of California, Los Angeles
Propofol, Dexmedetomidine
Impact of Two Different Types of Sedation on ICEB
The QT interval is a measure of the combination of cardiac depolarization and repolarization as it encompasses both the QRS complex and the J-T interval.
- Conditions
- Propofol, Dexmedetomidine, Electrophysiological Balance Index, QT Interval, Variation in
- Trial name
- NCT05757063
- Testing
- Sedation with propofol, sedation with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Qt Interval, Variation in
Investigation of Arrhythmogenic Effect of NPC-15 (NPC-15-7)
A study to assess the QTc prolongation effect of NPC-15 (melatonin 8mg or 16mg)
- Trial name
- NCT03475459
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nobelpharma
Hyperuricemia, Gout
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a Phase 1, single-center, randomized, partially double-blind, placebo- and positive controlled, 4-way crossover study to evaluate the effect of a therapeutic and a supratherapeutic dose of LC350189 on the QTcF in healthy…
- Conditions
- Hyperuricemia, Gout, Qt Interval, Variation in
- Trial name
- NCT04966325
- Testing
- LC350189 200mg, Moxifloxacin 400mg, LC350189 600mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- LG Chem
Atrial Arrhythmia, QT Interval, Variation in
QT Changes as Detected From LINQ ECG During Antiarrhythmic Loading (LINQ QT)
The LINQ QT Study is a prospective, non-randomized, multi-center, observational, post-market clinical study investigating QT interval changes due to antiarrhythmic drug loading.
- Conditions
- Atrial Arrhythmia, QT Interval, Variation in, Arrhythmias, Cardiac
- Trial name
- LINQ QT (NCT05488470)
- Testing
- LINQ/LINQ II
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure