Clinical trials: Quantitative Computed Tomography
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen
Guided Implant Placement, Delayed Implant
Qualitative and Quantitative Assessment of Marginal Bone Loss Following Flapless Guided Versus Conventional Implant Placement
Marginal bone preservation is an important determinant of long-term implant success. Conventional flap implant placement provides direct visualization of the surgical site but may disturb the periosteal blood supply and…
- Conditions
- Guided Implant Placement, Delayed Implant, CBCT Segmentation
- Trial name
- NCT07663045
- Testing
- Conventional Flap Implant Placement, Flapless guided implant
- Where
- United Arab Emirates
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Coronary Disease, Echocardiography
Meta-Analysis of Stress Myocardial Perfusion Imaging
Background: Detection of coronary artery disease (CAD) is important due to its high prevalence and its medical and economic implications.
- Conditions
- Coronary Disease, Echocardiography, Fractional Flow Reserve, Myocardial, Hemodynamics
- Trial name
- NCT03180060
- Where
- Mexico
- Volunteers
- 23,051 people
- Sponsor
- American British Cowdray Medical Center
Heart Failure, Pulmonary Hypertension
Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure
Heart failure (HF) patients often develop pulmonary hypertension (PH) that leads to transition into a biventricular HF with poor prognosis.
- Conditions
- Heart Failure, Pulmonary Hypertension, Pulmonary Vascular Resistance Abnormality
- Trial name
- LUNG-HF (NCT06331208)
- Testing
- non-contrast chest CT, spirometry with diffusing lung capacity for carbon monoxide (DLCO) analysis, Omics analysis of blood plasma obtained from pulmonary artery or peripheral blood
- Where
- Czechia
- Volunteers
- 230 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03251430
- Testing
- gastrectomy
- Where
- Japan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Kobayashi Shinichiro
Osteopenia
Study of the Effect of Once a Week Risedronate on the Microstructure of Tibia and Radius Using a New Scanning Method
The primary purpose of the protocol is to evaluate the sensitivity of 3D-pQCT (3D-Peripheral Quantitative Computed Tomography) technology to detect minute changes in bone microarchitecture.
- Trial name
- NCT00386360
- Testing
- risedronate
- Where
- 9 sites in Argentina, Australia and 5 more
- Volunteers
- 161 people
- Sponsor
- Warner Chilcott
Coronary Stenosis, Hemodynamics
Diagnostic Accuracy of CCTA-derived Versus AngiogRaphy-dErived QuantitativE Flow Ratio (CAREER) Study
To perform CT-QFR, invasive coronary angiography, FFR, and QFR tests on patients with moderate coronary stenosis after coronary CTA examination.
- Conditions
- Coronary Stenosis, Hemodynamics, Coronary Artery Disease, Coronary Computed Tomography Angiography
- Trial name
- CAREER (NCT04665817)
- Testing
- CT-QFR, QFR, FFR
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Fudan University
Coronary Artery Disease, Atherosclerosis
Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)
Regular endurance exercise is widely known to improve cardiovascular health and reduce the risk of heart disease. Yet several imaging studies have shown that male endurance athletes have a higher prevalence of coronary artery…
- Trial name
- MARC-3 (NCT07625488)
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Osteoporosis, Liver Steatosis
China Action on Spine and Hip Status
1. To determine the prevalences of osteoporotic fracture in elderly Chinese population. 2. To determine the prevalences of osteoporosis in elderly Chinese population using QCT BMD measurement. 3.
- Conditions
- Osteoporosis, Liver Steatosis, Metabolic Syndrome, Obesity
- Trial name
- CASH (NCT01758770)
- Where
- China
- Volunteers
- 3,457 people, healthy volunteers welcome
- Sponsor
- Beijing Jishuitan Hospital
Adult Onset Growth Hormone Deficiency
Bone Structure in Patients With Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed Tomography
The aim of the study is to assess bone geometry, bone compartment specific volumetric densities and micro-architecture as well as to evaluate non-invasive estimates of bone strength in patients with adult onset growth hormone…
- Trial name
- NCT02218710
- Where
- 3 sites in Denmark
- Volunteers
- 45 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease
Quantitative Analysis of Functional CT Imaging of Coronary Atherosclerosis
The purpose of this prospective observational study is to evaluate the diagnostic and prognostic performance of a "one-stop" comprehensive coronary artery anatomy and function assessment for CAD.
- Trial name
- NCT04986410
- Testing
- CCTA, CT-MPI, CT-FFR, SPECT-MPI
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Lung Function Testing, Cigarette Smoking
Evaluation of Ventilation Homogeneity as a Marker of Small Airway Disease in Active Smokers
Ventilation heterogeneity is a hallmark feature of most obstructive pulmonary diseases. In particular, chronic obstructive pulmonary disease (COPD) is pathologically and physiologically characterized by small airway destruction…
- Conditions
- Lung Function Testing, Cigarette Smoking, Single-photon Emission Computed Tomography (SPECT), Ventilation Homogeneity
- Trial name
- NCT03728712
- Testing
- SPECT/CT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Arthritis, Rheumatoid
Bone Erosions in Rheumatoid Arthritis - Characterization Evaluated by Imaging and Histology
The aim of this study is to describe macro- and micro anatomical structures, including investigating vessels running in osseous pores in finger joints from participants with rheumatoid arthritis (RA) using histology and different…
- Trial name
- BERA (NCT04645381)
- Where
- 2 sites in Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus
Chronic Airway Disease, Interstitial Lung Disease
WTC Chest CT Imaging Archive
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016.
- Conditions
- Chronic Airway Disease, Interstitial Lung Disease, Lung Cancer
- Trial name
- NCT03295279
- Where
- United States
- Volunteers
- 2,122 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cystinuria, Nephrolithiasis, Calcium Oxalate
Use of an Herbal Preparation to Prevent and Dissolve Kidney Stones
We will investigate the safety and effectiveness of a mixture of 9 east Indian herbs known as Cystone regarding their ability to dissolve existing kidney stones and prevent formation of new ones.
- Trial name
- NCT00381849
- Testing
- Cystone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Metastases to Bone, Metastatic Breast Cancer
Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS Study
Osteolytic bone metastases and myeloma bone lesions are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alter quality of life and that have a huge…
- Conditions
- Metastases to Bone, Metastatic Breast Cancer, Metastatic NSCLC
- Trial name
- MEKANOS (NCT04170634)
- Testing
- Evaluation of the fracture risk using data from routine qCT (quantitative Computed Tomography) scan and numerical simulation
- Where
- 12 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
Impact of Triple Combination CFTR Therapy on Sinus Disease.
The study's main goal is to observe how effective elexacaftor-tezacaftor-ivacaftor is for improving the symptoms and signs of CF-related sinus disease.
- Trial name
- NCT04056702
- Testing
- Elexacaftor-tezacaftor-ivacaftor exposure
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Jennifer Taylor-Cousar
Organ Transplant
Bone Microarchitecture in the Transplant Patient
The optimal management of calcium and phosphate metabolism regulation in chronic kidney disease (CKD) is important in preventing fracture risk and vascular calcification and thus morbidity and mortality, global and vascular.
- Trial name
- TRANSOS (NCT02729142)
- Testing
- Tibial cortical density evaluation
- Where
- 3 sites in France
- Volunteers
- 137 people
- Sponsor
- Hospices Civils de Lyon
Low Bone Mass, Low Bone Mineral Density
A High-resolution Peripheral Quantitative Computed Tomography Study in Postmenopausal Women Previously Treated With Denosumab
To evaluate the combined effect of denosumab treatment and discontinuation on cortical thickness at the distal radius by High Resolution-Peripheral Quantitative Computed Tomography (HR-pQCT).
- Conditions
- Low Bone Mass, Low Bone Mineral Density, Osteoporosis, Postmenopausal Osteoporosis
- Trial name
- NCT00890981
- Testing
- high-resolution peripheral quantitative computed tomography (HR-pQCT), Dual energy X-ray absorptiometry (DXA), Denosumab
- Volunteers
- 79 people
- Sponsor
- Amgen
Hypo or Hyperthyroidism
Thyroid Uptake Quantification Validation on a Three-dimensional (3D) Cadmium-Zinc-Telluride (CZT) New Generation Gamma Camera
Thyroid scintigraphy using technetium-99m (99mTc) pertechnetate is traditionally performed using planar imaging to estimate thyroid uptake.
- Trial name
- QThy2Dvc3D (NCT07610460)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Princesse Grace