Clinical trials: Quitting Smoking
Smoking Cessation
A Study of Cytisinicline for Smoking Cessation in Adult Smokers
This placebo-controlled Phase 3 study is being conducted at sites within the United States to evaluate 3 mg cytisinicline 3 times daily (TID) for treatment duration of 42 days/6 weeks and evaluate 3 mg cytisinicline TID for…
- Trial name
- ORCA-2 (NCT04576949)
- Testing
- Cytisinicline, Behavioral support
- Where
- 17 sites in United States
- Volunteers
- 810 people
- Sponsor
- Achieve Life Sciences
Smoking, Smoking Cessation
Intervention Study for Smoking Cessation in Spanish College Students
This study evaluate the effectiveness of a nurse multi-component intervention aimed at helping Spanish college student smokers to quit smoking.
- Trial name
- NCT03448900
- Testing
- Multicomponent intervention, Brief advice
- Where
- Spain
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Smoking Cessation
Clinical Trial to Evaluate the Efficacy of Smoking Cessation
The purpose of this study is to assess the efficacy of smoking cessation by using varenicline as monotherapy (VRN + placebo patches) or combined therapy (VRN + nicotine patches).
- Trial name
- COMBIVAR (NCT01538394)
- Testing
- Varenicline, Nicotine patches
- Where
- Spain
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Josep Maria Ramon Torrell, PhD
Smoking Cessation
Pilot Trial of the First Conversational Agent for Smoking Cessation (QuitBot)
Conversational agents (CAs) are computer-powered digital coaches designed to form long-term social-emotional connections with users through conversations. We have developed a CA for cigarette smoking cessation.
- Trial name
- QuitBot (NCT03585231)
- Testing
- Immediate access to novel messaging program intervention, Immediate access to standard of care messaging program intervention, Delayed access to novel novel messaging program intervention
- Where
- United States
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Use Disorder, Smoking Cessation
Implementation of Genomics in Substance Use Disorder Treatment
Cigarette smoking remains one of the leading causes of preventable death. Effective smoking cessation medications exist but use of these treatments is low, making it difficult for most to quit smoking.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Tobacco Use Cessation
- Trial name
- NCT04768114
- Testing
- Genetically-Informed RiskProfile, Brief Cessation Advice
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Smoking
Monitoring of Exhaled Carbon Monoxide to Promote Pre-operative Smoking Cessation
Smoking causes 90% of all lung cancer deaths among men and 80% of lung cancer deaths in women. Surgery is a great opportunity to help patients quit smoking.
- Trial name
- NCT01014455
- Testing
- Informing surgical patients about CO monitoring, a brief intervention recommending preoperative abstinence from smoking
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Mayo Clinic
Smoking Cessation, Tobacco Use Disorder
Promoting Home Smoking Restrictions: Biomarker Feedback to Smoking and Non-Smoking Adults
This study is directed at decreasing home environmental tobacco smoking (ETS) exposure with a novel approach of adoption of home smoking restrictions.
- Trial name
- NCT01497158
- Testing
- Self-help brochure, Biomarker feedback
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking Cessation
Veteran Support for Smoking Cessation Pilot Project (VAntage Pilot)
This is a proposal to conduct a pilot study to assess the feasibility of recruitment of Veteran smoker and support person (SP) dyads and study procedures in preparation for a large randomized pragmatic trial.
- Trial name
- VAntagePilot (NCT04840108)
- Testing
- Support Person Coaching Intervention, Support Person Written Materials
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Smoking Cessation
Efficacy and Safety Following Use of a Novel Nicotine Replacement Therapy
A comparison of a novel nicotine replacement therapy and placebo treatment in smokers motivated to quit smoking.
- Trial name
- NCT00882375
- Testing
- Nicotine
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 479 people
- Sponsor
- McNeil AB
Tobacco Use Cessation, Cancer Prevention
Project Impact 2: A Culturally Tailored Smoking Cessation Intervention for Latino Smokers
The goal of this research study is to learn how 3 different kinds of counseling treatments may help individuals to quit smoking.
- Trial name
- NCT02596711
- Testing
- Nicotine Patch, Questionnaires, Carbon Monoxide (CO) Test
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking Cessation
Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
The researchers are testing if counseling alone or counseling plus over-the-counter nicotine replacement therapies (NRT), like the patch,gum, or lozenge, helps African American non-daily smokers quit smoking.
- Trial name
- NCT02244918
- Testing
- Nicotine Replacement Therapy, Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Tobacco Use Disorder, Smoking Cessation
THCV Treatment for Smokers
This study will randomize 32 non-treatment-seeking individuals who smoke cigarettes daily into a randomized, crossover, double-blind, placebo-controlled study testing the safety, tolerability, and initial efficacy of…
- Trial name
- NCT07636356
- Testing
- Δ9-Tetrahydrocannabivarin (oral gummy)
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Smoking Cessation
A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
This study will determine whether varenicline is safe and helps people to quit smoking through reduction when they are not willing/able to make an abrupt quit attempt.
- Trial name
- NCT01370356
- Testing
- Varenicline Tartrate
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 1,510 people
- Sponsor
- Pfizer
Nicotine Dependence, Transcranial Magnetic Stimulation
Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products.
- Conditions
- Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation
- Trial name
- V-TMS (NCT07145866)
- Testing
- Varenicline, Transcranial Magnetic Stimulation, Nicotine Cessation Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation
Healing Within: Mindfulness Smoking Cessation Intervention
Using a highly participatory approach, this study will assess the feasibility, acceptability, and satisfaction with a culturally tailored, trauma-informed smoking cessation intervention for Northern Plains Tribal women who have…
- Trial name
- NCT07013968
- Testing
- culturally tailored, trauma-informed mindfulness smoking cessation intervention
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tobacco Use, Smoking
Salvation Army Tobacco Quit Line Referral Implementation Trial
The goal of this clinical trial is to understand how the Salvation Army staff can help people who use tobacco learn about and connect with no-cost treatments to help cut down or quit smoking.
- Conditions
- Tobacco Use, Smoking, Smoking Cessation
- Trial name
- NCT06689774
- Testing
- Cognitive-Motivational Feedback, Staff Tobacco Quit Line Referral Implementation Support, Consumer Incentives for Immediate Referral to a Tobacco Quit Line
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Wisconsin, Madison
Smoking Cessation
QuitAid Pilot Feasibility Trial
Adult smokers were recruited through an independent pharmacy in rural Appalachia and were randomized to 1 of 8 treatments, including medication and/or therapy from the pharmacist, to help quit smoking.
- Trial name
- NCT05649241
- Testing
- Nicotine patch, Nicotine gum, Medication Therapy Management
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Menthol Cigarettes, Smoking Behavior
DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes
<p>The goal of this clinical trial is to learn how exposure to anti-smoking social media messages affects quitting-related behaviors.
- Conditions
- Menthol Cigarettes, Smoking Behavior, Cigarette Use
- Trial name
- NCT07782879
- Testing
- Message Exposure via Discrete Choice Experiment
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Smoking Cessation, Early-Stage Cancer
Multi-Theory Model-Based AI Agent Intervention for Smoking Cessation in Early-Stage Cancer Patients
The goal of this clinical trial is to evaluate the effectiveness of a Multi-Theory Model (MTM)-based AI agent intervention for smoking cessation in early-stage cancer patients (clinical stage cTNM 0~II) who currently smoke.
- Conditions
- Smoking Cessation, Early-Stage Cancer, AI Agent
- Trial name
- NCT07827066
- Testing
- MTM-Based AI Agent for smoking cessation, Counseling
- Volunteers
- 156 people
- Sponsor
- Sun Yat-sen University
Smoking Cessation
The Effects of Electronic Cigarette Smoking on the Arterial Wall and Endothelial Glycocalyx Properties of Smokers
Electronic cigarette is proposed as a bridge to smoking cessation. In this study we examine its effects on aortic elasticity, glycocalyx integrity, and exhaled carbon monoxide (CO) concentration and platelet function, both…
- Trial name
- NCT03039920
- Testing
- Electronic cigarette, Conventional cigarette
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Athens