Clinical trials: RANDOMIZED
Wrinkle, Facial and Neck Skin Laxity
Evaluation of Safety and Efficacy of Micro-coring Device for Treatment of Facial Wrinkles and Skin Laxity
A pilot study is designed to evaluate safety and efficacy of the Micro-Coring (MC) technology for treatment of facial wrinkles. MC device employs hollow coring needles that enable safe, rapid, and effective full-thickness small…
- Trial name
- NCT03228641
- Testing
- micro-excisional skin removal with coring needle
- Where
- 6 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cytrellis Biosystems, Inc.
Postoperative Pain, Pelvic Organ Prolapse
The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation
This study will randomize patients to either receive intraoperative administration of local anesthetic and corticosteriod at time of sacrospinous ligament fixation compared to placebo to determine if intraoperative trigger point…
- Conditions
- Postoperative Pain, Pelvic Organ Prolapse, Trigger Point Injection, Sacrospinous Ligament Fixation
- Trial name
- NCT03995641
- Testing
- marcaine and kenalog
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kettering Health Network
Asthma
Sublingual Immunotherapy With House Dust Mite Extract in Asthmatic Children
Asthma, the airway inflammatory disorder, is an important chronic disease in children. About 10~15% children are bothered with this. Allergens, such as house-dust mites (HDM), animal dander (i.e.
- Trial name
- NCT00172341
- Testing
- Staloral TM
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Intra-abdominal Infections
LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Intra-abdominal Infection (cIAI)
The purpose of the study was to evaluate whether LYS228 can be developed for the treatment of complicated intra-abdominal infections.
- Trial name
- NCT03354754
- Testing
- LYS228, Standard of care therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Safety and Efficacy of Terlipressin and Noradrenaline and Predictive Factors of Response in Type 2 HRS
TYPE 2 HEPATORENAL SYNDROME
Various vasoconstrictors have shown promising results in the management of type 1 hepatorenal syndrome (HRS). However, there are very few studies on vasopressors in the management of type 2 HRS.
- Trial name
- Type2 HRS (NCT01637454)
- Testing
- Noradrenaline, Terlipressin
- Where
- India
- Volunteers
- 46 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Arthritis Shoulder, Rotator Cuff Injuries
Onlay Versus Inlay Humeral Component in Reverse Total Shoulder Arthroplasty
The goal of this study is to compare the effect of different ways to place the component that goes at the top of the humerus (upper arm) in reverse total shoulder replacement.
- Trial name
- NCT05297305
- Testing
- Tornier Ascend Flex stem, Tornier Perform Stem Reverse+
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Corewell Health East
Plantar Fasciitis
Efficacy of a Custom Temporary Foot Orthosis for Plantar Fasciitis Treatment
The aim of this randomized control trial is to identify the possible effectiveness of the temporary use of an inexpensive, custom-made plantar fascia orthotic (PFO).
- Trial name
- NCT01882894
- Testing
- Custom PFO, Faux orthosis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Puget Sound
Fibrosis
First in Human Study in Healthy Volunteers Followed With Dosing in Participants With Lung or Liver Fibrosis
First in Human single ascending dose followed by multiple ascending doses in healthy volunteers.
- Trial name
- NCT03559166
- Testing
- BLD-2660
- Where
- Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Blade Therapeutics
Prostate Cancer, Urinary Incontinence
The Efficacy of Pilates in the Recovery of Post-prostatectomy Urinary Incontinence
The purpose of this study is to compare the efficacy between a Pilates exercise program and a Pelvic Floor Muscle Training (PFMT) protocol combined with anal electrical stimulation (AES) in the recovery of urinary continence (UI)…
- Trial name
- NCT02086266
- Testing
- PILATES, PFMT and AES
- Volunteers
- 54 people
- Sponsor
- Universidade Estadual de Londrina
Surgical Wound
RESPECT Trial - (Rapid Extravascular Sealing Via PercutanEous Collagen ImplanT)
The objective of this trial is to demonstrate the safety and effectiveness of the Cardiva VASCADE™ Vascular Closure System (VCS) in sealing femoral arterial access sites.
- Trial name
- RESPECT (NCT01297322)
- Testing
- Manual compression, Cardiva VASCADE™ Vascular Closure System
- Where
- 21 sites in United States, Australia
- Volunteers
- 420 people
- Sponsor
- Cardiva Medical, Inc.
Irritable Bowel Syndrome (IBS)
Study to Determine the Effectiveness of the Probiotic E. Coli Strain M17 in Treating Irritable Bowel Syndrome (IBS)
The purpose of this study is to determine the tolerance and efficacy of the probiotic E. Coli Strain M17 on symptoms and Quality of Life in Individuals with Irritable Bowel Syndrome (IBS).
- Trial name
- NCT00194922
- Testing
- E. Coli Strain M17 Probiotic
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Weill Medical College of Cornell University
Smoking Cessation
Pharmacokinetic Study of 4 mg Nicotine Lozenge.
This is a randomized, single center, open label, single dose, four way crossover study in fasted healthy male subjects to compare the pharmacokinetics of nicotine following administration of 3 prototype 4mg nicotine lozenge to an…
- Trial name
- NCT01669122
- Testing
- nicotine
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
End-Stage Kidney Disease, Peritoneal Dialysis
Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients
Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis (PD) for long period of time.
- Trial name
- NCT01111422
- Testing
- N-acetylcysteine
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Ewha Womans University
Healthy
Bioequivalence of a Single Subcutaneous Dose of BEPO and REPO in Healthy Male Subjects
To Compare Pharmacokinetic and Pharmacodynamic Profiles of BEPO-A and REPO-A in Healthy Male Subjects
- Trial name
- NCT02426151
- Testing
- BEPO-A, REPO-A
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Healthy Volunteers
Effect of Teduglutide on Gastric Emptying in Healthy Subjects
The primary objective of this study is to assess the effects of 10 consecutive, daily, subcutaneous doses of 4 mg of teduglutide as compared with placebo on gastric emptying as assessed by acetaminophen absorption kinetics in…
- Trial name
- NCT01209351
- Testing
- teduglutide
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shire
Multiple Myeloma (MM)
A Study to Evaluate the Safety and Efficacy of SCTC21C in Combination With Bortezomib, Lenalidomide and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
The purpose of this study is to evaluate if the addition of SCTC21C to bortezomib, lenalidomide and dexamethasone (VRd) in patients with newly diagnosed multiple myeloma not eligible for transplant will prolong progression-free…
- Trial name
- NCT07297329
- Testing
- SCTC21C, Bortezomib, Lenalidomide
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Sinocelltech Ltd.
Chronic Hepatitis B
A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334 in Subjects With Chronic Hepatitis B Virus Infection
This is a randomized, blinded, placebo-controlled, dose-ranging Phase 1b study of the safety, PK, and antiviral activity of ABI-4334 in treatment-naïve or off-treatment chronic Hepatitis B virus (cHBV) subjects that are Hepatitis…
- Trial name
- NCT06384131
- Testing
- ABI-4334
- Where
- 2 sites in Moldova, New Zealand
- Volunteers
- 20 people
- Sponsor
- Assembly Biosciences
Cryotherapy Effect, Balance; Disorder, Fluid
Effect on Dynamic Postural Stability After Application of Cryotherapy to the Knee Joint
The purpose of this study will determine the effect of cryotherapy applied to the knee joint on static and dynamic standing balance.
- Trial name
- NCT03151031
- Testing
- Cryotherapy
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Colostomy Site
Comparison of Two Different Solutions for Peristomal Skin Care in Patients With Pediatric Stoma
The aim of this study is to determine the effect of two different skin care solutions used in stoma care on peristomal skin integrity and compare them with each other.
- Trial name
- NCT05686902
- Testing
- CLEANING SOLUTION
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Izmir Katip Celebi University
Bioequivalence
A Bioequivalence Study Between Fluticasone Salmeterol Xinafoate vs. ADVAIR DISKUS® in Healthy Volunteers
Bioequivalence study between two inhaler products of fixed dose combination of fluticasone propionate and salmeterol xinafoate inhalation powder
- Trial name
- BREATH-PK500 (NCT03751202)
- Testing
- Fluticasone propionate 500 mcg and salmeterol xinafoate 50 mcg, ADVAIR DISKUS
- Where
- Greece
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Respirent Pharmaceuticals Co Ltd.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.