Clinical trials: RANDOMIZED
Alcoholism, Cocaine Dependence
Topiramate for Alcohol and Cocaine Dependence
The primary purpose of this study is to test the effectiveness of topiramate for the treatment of combined alcohol and cocaine dependence. Topiramate is approved for the treatment of seizures.
- Trial name
- TOP2 (NCT00167245)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Kyle Kampman
Hepatitis C Virus
Japanese Bridging Study Conducted in the United States
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics following single oral and multiple oral doses BMS-791325 in healthy Japanese subjects.
- Trial name
- NCT00947245
- Testing
- BMS-791325
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Metastatic Breast Cancer
To Compare Treatment With Doxorubicin or Capecitabine for Metastatic Breast Cancer in Women 60 Years and Older
The main purpose of this study is to compare treatment with either pegylated liposomal doxorubicin or capecitabine as first line chemotherapy for metastatic breast cancer in women 60 years and older.
- Trial name
- NCT00082095
- Testing
- Pegylated liposomal doxorubicin, Capecitabine
- Where
- 27 sites in United States
- Volunteers
- 62 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Fibromyalgia, Psychological Trauma
Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
Fibromyalgia (FM) is a generalized, widespread chronic pain disorder and has an estimated prevalence of 2%-4% in the general population.
- Conditions
- Fibromyalgia, Psychological Trauma, Depressive Symptoms, Anxiety
- Trial name
- NCT04084795
- Testing
- Eye Movement Desensitization and Reprocessing therapy, transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Parc de Salut Mar
Anal Fistula
Fistulotomy With or Without Marsupialization for Treatment of Simple Anal Fistula
Patients with simple anal fistula will undergo fistulotomy operation and will be divided into two groups: the first will undergo marsupialization of the laid open fistula track and second group will not undergo marsupialization.
- Trial name
- NCT03595839
- Testing
- Fistulotomy, Marsupialization
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Schizophrenia
Staccato Loxapine in Agitation (Proof of Concept)
The purpose of this study is to assess efficacy and safety of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients.
- Trial name
- NCT00369577
- Testing
- Inhaled Loxapine 5 mg, Inhaled Loxapine 10 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Pain, Postpartum Depression
Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term.
- Trial name
- NCT03470675
- Testing
- Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Northwestern University
Sepsis
Pilot Trial of External Warming in Septic Patients
The purpose of this study is to determine whether externally warming critically ill afebrile adult septic patients will improve indices of immune function and/or clinical outcomes.
- Trial name
- NCT02706275
- Testing
- External warming
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Physical Activity, Incentives
TAKing Steps for Incentives
The purpose of this study is to test the overall effects of incentives on physical activity among older taxi drivers, and whether mental accounting exists in this context.
- Trial name
- TAKSI (NCT01892475)
- Testing
- Incentive-based physical activity program, 3-month follow up
- Where
- Singapore
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Irreversible Pulpitis
Clinical and Radiographic Evaluation of Propolis as a Hemostatic Agent in Full Pulpotomy of Mature Permanent Molars With Irreversible Pulpitis
The goal of this randomized clinical trial is to assess the effectiveness of propolis as a hemostatic agent in full pulpotomy for mature permanent molars with irreversible pulpitis, compared to sodium hypochlorite (NaOCl).
- Trial name
- NCT06679075
- Testing
- Full pulpotomy using propolis and bioceramic putty, Full pulpotomy using Propolis and MTA, Full pulpotomy using sodium hypochlorite and bioceramic putty
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Misr International University
HIV
TMC114-C211: Trial of an Investigational Protease Inhibitor TMC114 With Ritonavir ("TMC114/r") in HIV-1 Infected Patients Who Have Never Been Treated With Antiretroviral Medications.
The purpose of this study is to compare the efficacy, safety and tolerability of TMC114/r versus Kaletra (a combination pill of lopinavir and ritonavir, ("lpv/rtv") in HIV-1 infected patients who have never been treated with…
- Trial name
- NCT00258557
- Testing
- LPV/RTV, TMC-114/RTV
- Where
- 89 sites in United States, Argentina and 23 more
- Volunteers
- 692 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Opioid Use Disorder
KIOS Mobile App Evaluation
Evaluation of a mobile medical app (KIOS) vs. treatment as usual for the treatment of opioid use disorder (OUD).
- Trial name
- NCT06212557
- Testing
- KIOS App, KIOS App education, Treatment as usual
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Knee Osteoarthritis
Therapeutic Effects of Insoles on Patients With Knee Osteoarthritis
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ready-made full-length lateral wedged shoe insoles and customized full-length lateral wedged shoe…
- Trial name
- NCT01765101
- Testing
- customized insoles, ready made insoles
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Degenerative Joint Disease of Knee, Rheumatoid Arthritis
Intra-Articular Adelmidrol 2%/Hyaluronic Acid 1% With or Without m/umPEA, in Knee Pain Due to Joint Degeneration.
Degenerative knee joint diseases are characterized by chronic pain, inflammation, and functional impairment. In these conditions, mast cell density in the synovial membrane is increased, resulting in an excessive release of…
- Trial name
- NCT07680101
- Testing
- Adelmidrol 2% / Hyaluronic Acid 1%, micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Universita di Verona
HIV Neuropathy
OPEN Feasibility Study
The current trial will explore the feasibility of a larger efficacy trial to test a newly developed form of online CBT called Acceptance and Commitment Therapy (which we have called "ACT OPEN") for people with HIV and painful…
- Trial name
- NCT03584412
- Testing
- ACT OPEN, Waiting list control
- Where
- 3 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College London
Migraine Headache
Cupping and Serkangabin Versus Conventional Migraine Treatment
Migraine is the most common recurrent headache. Current therapy of migraine headache consists of multiple drug groups for control of attack and prophylaxis against recurrent attacks.
- Trial name
- NCT01476930
- Testing
- cupping and serkangabin syrup, conventional migraine drug treatment
- Where
- Iran
- Volunteers
- 391 people
- Sponsor
- Birjand University of Medical Sciences
Heart Failure, Congestive, Heart Decompensation
A Study of Two Doses of Intravenous NATRECOR hBNP (Nesiritide) in Patients With Worsening Congestive Heart Failure Who Have Difficulty Breathing at Rest
The purpose of this study is to assess the safety and efficacy of two doses of intravenous NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart) versus placebo in the treatment of…
- Trial name
- NCT00288730
- Testing
- nesiritide
- Volunteers
- 127 people
- Sponsor
- Scios, Inc.
Virtual Reality, Anxiety
The Effect of Virtual Reality Application on Anxiety and Patient Satisfaction During Intrauterine Insemination (IUI)
This study will conduct as a randomized pretest-posttest study to examine the effect of virtual reality glasses (VRG) application during the IUI procedure on anxiety and patient satisfaction.
- Conditions
- Virtual Reality, Anxiety, Patient Satisfaction, Intrauterine Insemination (IUI)
- Trial name
- (IUI) (NCT06346730)
- Testing
- Virtual reality glasses to intervention group
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Systemic Lupus Erythematosus
PRV-3279-2a Trial in Systemic Lupus
The PREVAIL-2 study was designed to assess the safety and potential efficacy of PRV-3279 in flare prevention in systemic lupus erythematosus (SLE) participants with active disease after amelioration induced by corticosteroid…
- Trial name
- PREVAIL-2 (NCT05087628)
- Testing
- PRV-3279
- Where
- 36 sites in United States, China and 2 more
- Volunteers
- 28 people
- Sponsor
- Provention Bio, a Sanofi Company
Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol
Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices
Cirrhosis is a serious liver disease where scar tissue replaces healthy liver tissue, often leading to portal hypertension-a condition where blood pressure in the liver's blood vessels rises.
- Conditions
- Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol, Carvedilol
- Trial name
- NCT07352228
- Testing
- Propranolol, Carvedilol
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Xijing Hospital
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