Clinical trials: RANDOMIZED
Vascular Access Complication, Vascular Access Site Bruising
Comparison of Ultrasound-guided and Palpation-inserted Peripheral Venous Cannula
Every patient need venous access for surgery under anesthesia. It is the most frequently performed invasive procedure in medicine in the whole world.
- Trial name
- CompOne (NCT05156008)
- Testing
- Ultrasound-guided vascular access
- Volunteers
- 200 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Prevention of Pneumonic Plague Resulting From Aerosol Exposure to Yersinia Pestis
Immunogenicity, Safety, and Tolerability of rF1V-1018 Vaccine in Adults 18 to 55 Years of Age
This study will evaluate the immunogenicity, safety, and tolerability of rF1V-1018 vaccine
- Trial name
- NCT07207408
- Testing
- rF1V-1018
- Where
- 4 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Dynavax Technologies Corporation
Covid-19
Efficacy of Subcutaneous Sarilumab in Hospitalised Patients With Moderate-severe COVID-19 Infection (SARCOVID)
The global health emergency created by the rapid spread of the SARS-CoV-2 coronavirus has pushed healthcare services to face unprecedent challenges to properly manage COVID-19 severe and critical manifestations affecting a wide…
- Trial name
- SARCOVID (NCT04357808)
- Testing
- Sarilumab, Standar of care
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Maria del Rosario Garcia de Vicuña Pinedo
Covid19
Ivermectin to Prevent Hospitalizations in COVID-19
It is a single-center, prospective, randomized, double-blind, placebo-controlled study carried out by the Ministry of Public Health of the Province of Corrientes, Argentina, in coordination with the Corrientes Institute of…
- Trial name
- IVERCORCOVID19 (NCT04529525)
- Testing
- Ivermectin
- Where
- Argentina
- Volunteers
- 501 people
- Sponsor
- Instituto de Cardiología de Corrientes
Anxiety, Pain
The Effect of Virtual Reality Glasse on Pain and Anxiety During Episiotomy Repair
Episiotomy is one of the common surgical operations that can cause anxiety in women and have side effects such as pain. Nerve blockades with analgesic effects such as lidocaine used during episiotomy repair or the use of…
- Conditions
- Anxiety, Pain, Episiotomy Wound, Midwifery
- Trial name
- NCT05198908
- Testing
- VR group, Skin to skin group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Bipolar Disorder
Tryptophan Depletion in Acute Mania
Serotonin (5-HT) is important in mood regulation and is believed to play a major role in the pathophysiology of major depression (MD).
- Trial name
- NCT00192725
- Testing
- rapid tryptophan depletion
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Tuberculosis
A Trial of Isoniazid for the Reversion of Interferon Gamma ELISPOT in Tuberculosis (TB) Case Contacts
There are new TB vaccines already developed that need to be tried in humans to assess their efficacy. The researchers had previously shown that production of interferon gamma by T cells in response to TB antigens is a more…
- Trial name
- IRS (NCT00130325)
- Testing
- Isoniazid
- Where
- The Gambia
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Medical Research Council Unit, The Gambia
Plaque, Atherosclerotic
Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction
This study is to evaluate the effect of Inclisiran on coronary atherosclerosis using intravascular ultrasound (IVUS) and optical coherence tomography (OCT) in patients with acute myocardial infarction and elevated low-density…
- Trial name
- V-ACCELERATE (NCT06372925)
- Testing
- atorvastatin, IVUS/OCT, inclisiran
- Where
- 19 sites in China
- Volunteers
- 318 people
- Sponsor
- Novartis Pharmaceuticals
Smoking Cessation
Nicotine Substitute Prescribed at Hourly Intake or ad Libitum for Heavy Smokers Willing to Quit
Objective: To assess the impact of instructional guidance in the regular use of use nicotine nasal spray (NNS) on the true use of NNS during the first three weeks of smoking cessation for heavy smokers who are willing to quit.
- Trial name
- SUNIC (NCT00861276)
- Testing
- Nasal Spray Nicotine Substitute (Experimental), Nasal Spray Nicotine Substitute (ad libitum)
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Helicobacter Pylori Infection
Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection…
- Trial name
- NCT05129176
- Testing
- Levofloxacin, Metronidazole
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shandong University
Coronary Artery Bypass Graft Surgery (CABG), Pain
Effect of Swedish Hand Massage on Pain in Patients Undergoing CABG Surgery
Coronary Artery Bypass Grafting (CABG) surgery is performed commonly today. Heart surgery performed on more than two million individuals every year leads patients experience severe postoperative pain for causes such as cutting of…
- Conditions
- Coronary Artery Bypass Graft Surgery (CABG), Pain, Pain Management, Nursing
- Trial name
- NCT06688617
- Testing
- Swedish Hand Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Pain, Pain, Postoperative
Opioid-Free Orthopaedics
The goal of this investigation is to compare effectiveness of this multimodal regimen at controlling postoperative pain with and without the use of opioid medications.
- Trial name
- NCT04659317
- Testing
- Oxycodone 5 mg Oral Tablet
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
HIV Infections, HIV
Interluekin-7 to Treat HIV-Infected People Receiving Antiretroviral Treatment
This study will evaluate whether interleukin-7 (IL-7) a drug similar to the natural IL-7 protein produced by the body, is safe to use in people infected with HIV. IL-7 is important in immune system function.
- Trial name
- NCT00105417
- Testing
- IL-7
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Operable Breast Cancer
Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer
Voltage Gated Sodium Channels Over the years, there is more evidence that ionic channels are involved in the oncogenic process. Among these, voltage gated sodium channels (VGSC) expressed in non-nervous or non-muscular organs are…
- Trial name
- NCT01916317
- Testing
- 0.5% lignocaine 60mM
- Where
- 11 sites in India
- Volunteers
- 1,600 people
- Sponsor
- Tata Memorial Hospital
Family Planning
Misoprostol Prior to IUD Insertion in Nullipara
The use of misoprostol at a dose of 400 µg administered vaginally four hours prior to IUD insertion increased the ease of insertion and reduced the incidence of pain during the procedure, although the frequency of cramps…
- Trial name
- NCT03490617
- Testing
- Vaginal misoprostol
- Where
- Brazil
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
COPD (Chronic Obstructive Pulmonary Disease)
Isoinertial Training in Patients With COPD
Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and…
- Trial name
- ISTrainingCOPD (NCT07605117)
- Testing
- Isoinertial training, Traditional rehabilitation (control group)
- Where
- 2 sites in Colombia
- Volunteers
- 30 people
- Sponsor
- Universidad Manuela Beltrán
Metastatic Malignant Neoplasm to the Adult Brain
Sector Irradiation Versus Whole Brain Irradiation for Brain Metastasis
Microneurosurgical resection of intracerebral metastases leads to prolonged survival and relief of symptoms in selected patients.
- Trial name
- NCT01667640
- Testing
- sector irradiation, whole brain irradiation
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University Innsbruck
Testicular Neoplasms, Seminoma
Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer
One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors.
- Trial name
- SWENOTECA-ABC (NCT02341989)
- Testing
- Bleomycin Etoposide and Cisplatin, Carboplatin
- Where
- 2 sites in Norway
- Volunteers
- 348 people
- Sponsor
- St. Olavs Hospital
Bariatric Surgery Candidate, Extubation
Evaluation of Advanced Extubation Techniques in Bariatric Surgery
The aim of prospective clinic study is to compare the tolerance and effectivity of Cook tube changing catheter and staged extubation set following laparoscopic morbid obesity surgery.
- Trial name
- NCT03715257
- Testing
- 14F staged extubation set guidewire, Tube changing catheter
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Non-Small Cell Lung Cancer (NSCLC)
A Clinical Study in Three-arm of Lurbinectedin (PM01183) Alone or in Combination With Gemcitabine and a Control Arm With Docetaxel as Second Line Treatment in Non-Small Cell Lung Cancer (NSCLC) Patients
A clinical study of lurbinectedin(PM01183) alone or in combination with gemcitabine in comparison to docetaxel for the treatment of unresectable non-small cell lung cancer (NSCLC)patients
- Trial name
- NCT01951157
- Testing
- Docetaxel, Gemcitabine, Lurbinectedin (PM01183)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- PharmaMar
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