Clinical trials: RDS
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI)
A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation
Sepsis is a systemic inflammatory response syndrome triggered by infection, and it is a common critical illness in clinical practice, often leading to multiple organ dysfunction.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI), Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
- Trial name
- NCT07342205
- Testing
- Human-derived active intestinal bacterial liquid group
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
ARDS, Human, Sepsis, Severe
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective randomized study.
- Trial name
- NCT04508296
- Testing
- Goal directed de-escalation therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Northern State Medical University
SARS-CoV-2, Influenza, Human
Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)
The purpose of this clinical trial is to evaluate the safety, tolerability and efficacy of two doses (dose A and dose B) of Standardized Conditioned Medium Obtained by Coculture of M2-macrophages and fat-derived Mesenchymal…
- Conditions
- SARS-CoV-2, Influenza, Human, Respiratory Syncytial Virus Infections, Respiratory Distress Syndrome
- Trial name
- NCT06684379
- Testing
- PRS CK STORM
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- PEACHES BIOTECH
Preterm Infant
Sustained Lung Inflation in Preterm Infants
This is a randomized controlled study to investigate the effect of application of sustained lung inflation (SLI) at birth on the respiratory outcome of preterm infants with respiratory distress syndrome.
- Trial name
- NCT03518762
- Testing
- Sustained lung inflation (SLI), Continuous positive airway pressure (CPAP)
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Kasr El Aini Hospital
Acute Respiratory Distress Syndrome (ARDS), Prone Position Ventilation
Machine Learning Prediction of Mortality After Prone Positioning in ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality. Prone position ventilation (PPV) is an evidence-based therapy that improves oxygenation and survival in patients with moderate to…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Prone Position Ventilation, Machine Learning, ICU
- Trial name
- NCT07445061
- Testing
- Prone Position Ventilation
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Shanghai Zhongshan Hospital
COVID-19 Acute Respiratory Distress Syndrome
Is Prolonged Period of Prone Position Effective and Safe in Mechanically Ventilated Patients With SARS-COV-2?
the aim of the study is to assess safety and efficacy of prone position ventilation beyond the usual 16 hrs in patients with SARS-COV-2
- Trial name
- NCT05109624
- Testing
- prolonged prone position ventilation
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
Therapeutic plasma exchange (TPE) has been proposed as a rescue therapy in critically ill COVID-19 patients. The aim of this study is to determine whether combining TPE with convalescent plasma (CVP) transfusion early during the…
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04973488
- Testing
- Therapeutic plasma exchange
- Where
- Romania
- Volunteers
- 38 people
- Sponsor
- Novacescu Alexandru
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Post Intensive Care Syndrome, ARDS: Acute Respiratory Distress Syndrome
Combined Activity and Cognitive Intervention for ICU Survivors
This mixed-methods study comprising a 3-arm pilot RCT and a qualitative study aims to investigate the preliminary effects and feasibility of a home-based combined activity and cognitive intervention for ICU survivors…
- Conditions
- Post Intensive Care Syndrome, ARDS: Acute Respiratory Distress Syndrome, Delirium, Loss of Muscle Mass
- Trial name
- NCT06117761
- Testing
- Home-based exercises combined with cognitive training, Home-based exercises
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Acute Respiratory Distress Syndrome (ARDS), Intensive Care Units (ICUs)
Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol
Despite best supportive care, mortality of the Acute Respiratory Distress Syndrom (ARDS) remains high. In the absence of specific treatments, providing safe and efficient mechanical ventilation (MV) is key to survival.
- Trial name
- PEPER (NCT06849570)
- Testing
- Minimal distension, Maximal Recruitment, Prone position + early NMBAs
- Where
- 29 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, ARDS, Human
Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury
The investigators present a randomised open label phase Ib/IIa trial of nebulised unfractionated heparin to evaluate the effect of nebulised unfractionated heparin on the procoagulant response in ICU patients with SARS-CoV-2…
- Conditions
- Covid19, ARDS, Human, Lung Injury, Acute, Ventilation Perfusion Mismatch
- Trial name
- CHARTER-Irl (NCT04511923)
- Testing
- Nebulised heparin
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway
ARDS (Acute Respiratory Distress Syndrome)
EXTEND ARDS-J Esophageal Pressure Study
Background: Acute respiratory distress syndrome (ARDS) patients require careful assessment before extubation to prevent failure, which is associated with poor outcomes.
- Trial name
- NCT06734988
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Sapporo Medical University
Covid19, COVID-19 Pneumonia
Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients (COVASP)
COVID-19 is respiratory disease caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel coronavirus which has spread rapidly across the world with over 149.9 million laboratory confirmed cases and over 3.1…
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Lower Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- COVASP (NCT04896866)
- Testing
- Antimicrobial stewardship prospective audit and feedback
- Where
- 3 sites in Canada
- Volunteers
- 833 people
- Sponsor
- University of Alberta
Covid19, ARDS, Human
Prone Positioning Short-term Effects on Tissue Oxygen Saturation in Critical COVID-19 Patients
The purpose of this study is to monitor short-term changes in tissue oxygen saturation and local blood flow as results of changing from supine to prone position in ARDS COVID-19 patients
- Trial name
- PRONECOVID19 (NCT04692129)
- Where
- 6 sites in Brazil, Mexico and 1 more
- Volunteers
- 100 people
- Sponsor
- Corporacion Parc Tauli
Respiratory Distress Syndrome, Adult, Acute Lung Injury
A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury
The purpose of this study is to determine whether sivelestat will reduce the amount of time a patient must spend on a ventilator and/or increase the chance of survival of patients with acute lung injury.
- Trial name
- NCT00036062
- Testing
- Sivelestat
- Where
- 110 sites in United States, Australia and 4 more
- Volunteers
- 600 people
- Sponsor
- Eli Lilly and Company
Infant, Newborn, Hypertension, Pulmonary
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns
This prospective, randomized controlled trial tested whether initiating iNO therapy earlier would reduce death and reduce the use of extracorporeal membrane oxygenation (ECMO) -- temporary lung bypass -- therapy compared with the…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- Early iNO (NCT00005773)
- Testing
- Inhaled Nitric Oxide, Standard iNO therapy
- Where
- 18 sites in United States
- Volunteers
- 302 people
- Sponsor
- NICHD Neonatal Research Network
Persistent Pulmonary Hypertension, Respiratory Distress Syndrome
Treatment of Elevated Arterial Pulmonary Pressure With Inhaled Iloprost
The purpose of this study is to determine if iloprost is effective in the treatment of elevated arterial pulmonary pressure in children with ventilator treated respiratory distress syndrome.
- Trial name
- NCT00216931
- Testing
- iloprost
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Lund University Hospital
Preterm, Premature
Effects of Kinesiotaping on Respiratory Muscles in Very Preterm Infants
This study aimed to evaluate the effects of kinesio taping on blood gas parameters, respiratory rate, heart rate, oxygen saturation, and pressure limits in preterm infants with RDS who are on NIV.
- Conditions
- Preterm, Premature, Infant, Newborn, Diseases, Respiratory Distress Syndrome
- Trial name
- NCT06285669
- Testing
- kinesiotaping application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ondokuz Mayıs University
Acute Respiratory Distress Syndrome
Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients
This is a single-center, prospective, randomized, three-period crossover physiological study in adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS, PaO₂/FiO₂ ≤150 mmHg).
- Trial name
- SBA-APRV (NCT07798154)
- Testing
- APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Adult Respiratory Distress Syndrome, Acute Lung Injury
Simvastatin Effect on the Incidence of Acute Lung Injury/Adult Respiratory Distress Syndrome (ALI/ARDS)
Acute Lung Injury/Acute respiratory distress syndrome (ALI/ARDS) is a serious and frequently encountered entity in modern ICUs. Sepsis remains the most common cause of ALI/ARDS and carries the worst prognosis.
- Trial name
- NCT01195428
- Testing
- Simvastatin
- Where
- 2 sites in United States
- Sponsor
- University of Oklahoma
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