Clinical trials: RECTAL NEOPLASMS
Metastatic Colorectal Cancer
A Study Assessing Adverse Events and Disease Activity of Intravenously (IV) Infused Telisotuzumab Adizutecan in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer
Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide and in China. The purpose of this study is to assess adverse events and change in disease activity of intravenously (IV) infused telisotuzumab…
- Trial name
- NCT06614192
- Testing
- Telisotuzumab Adizutecan
- Where
- 51 sites in United States, Australia and 5 more
- Volunteers
- 74 people
- Sponsor
- AbbVie
Colorectal Cancer, Diarrhea
Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy
RATIONALE: Genetic testing may help predict how patients will respond to chemotherapy drugs and may help doctors plan more effective treatment with fewer side effects.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT00048971
- Testing
- mutation analysis, polymorphic microsatellite marker analysis
- Where
- 84 sites in United States, Canada and 1 more
- Volunteers
- 308 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer (CRC)
Advances in Imaging to Assess Response in Rectal Cancer
The goal of this observational study is to determine the feasibility of acquiring serial MRI images for advanced radiotherapy planning in colorectal patients.
- Trial name
- AIR-REC (NCT06822634)
- Testing
- Observational single centre feasibility study
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Colorectal Cancer, Dysgeusia
Bovine Lactoferrin in Reducing Taste Disturbances in Patients With Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy
The purpose of this research study is to determine if using a lactoferrin supplement will improve taste perception. Lactoferrin is a type of protein that is naturally produced in the body and is commonly found in saliva.
- Conditions
- Colorectal Cancer, Dysgeusia, Oral Complications of Chemotherapy
- Trial name
- NCT01596634
- Testing
- questionnaire administration, quality-of-life assessment, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Metastatic Colorectal Cancer, Advanced Colorectal Cancer
Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer
RBS2418 is a specific immune modulator that works through the inhibition of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and is designed to lead to anti-tumor immunity by protecting endogenous 2'-3'-cyclic guanosine…
- Trial name
- VISTA-1 (NCT06824064)
- Testing
- RBS2418
- Where
- 5 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- Riboscience, LLC.
Carcinoma of the Appendix, Colorectal Cancer
Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Carcinoma of the Appendix, Colorectal Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00458809
- Testing
- oxaliplatin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Rectal Cancer
Effect of a Post-operative Protocol of Early Mobilization on Functional Recovery and Postoperative Complications After Immediate Internal Pudendal Artery Perforator Flap Reconstruction for Irradiated Abdominoperineal Resection Defects: a Prospective, Randomized and Controlled Clinical Study.
Major abdominal oncology surgery is associated with substantial postoperative loss of functional capacity, and exercise may be an effective intervention to improve outcomes.
- Trial name
- NCT04795609
- Testing
- Early mobilization strategy adapted after immediate internal pudendal artery perforator flap reconstruction for abdominoperineal resection (intervention group).
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Advance Solid Tumors, Colon and Rectal Cancer
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutations
This is a Phase 1 and Phase 2 study to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of INV-8989 in patients with advanced solid tumors harboring KRAS G12D mutations.
- Conditions
- Advance Solid Tumors, Colon and Rectal Cancer, Non - Small Cell Lung Cancer NSCLC, Pancreatic Adenocarcinoma Advanced or Metastatic
- Trial name
- NCT07610798
- Testing
- INV-8989
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Shenzhen Ionova Life Sciences Co., Ltd.
Prostate Cancer, Rectal Cancer
Video Analysis of Errors and Technical Performance Within Minimally Invasive Surgery Short Title: Video Analysis in Minimally Invasive Surgery (VAMIS)
Despite the high volumes, advanced minimally invasive surgery is non-standardised and variations often occur in surgical technique, performance, delivery, team communication, and surgical approach.
- Trial name
- VAMIS (NCT05279287)
- Testing
- Video and kinematic data recording of minimally invasive surgical procedure
- Where
- 5 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Griffin Institute
Colorectal Cancer
Psychological Predictors in Colorectal Cancer Surgery Recovery
This is an observation pilot trial aimed to study to the association between mindfulness and other psychological factors, including both protective and risk factors, with recovery of functional ability following colorectal cancer…
- Trial name
- MIND (NCT03781193)
- Testing
- Questionnaires administration, Five Facet Mindfulness Questionnaire (FFMQ), Langer Mindfulness Scale (LMS)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Clinico Humanitas
Advanced Colorectal Cancer
A Phase II Trial of Salvage Treatment With Gemcitabine and S-1 Combination in Patients With Heavily Treated Advanced Colorectal Cancer.
To assess the efficacy and safety of salvage tratment with Gemcitabine and S-1 Combination in metastatic colorectal cancer
- Trial name
- NCT01929421
- Testing
- Gemcitabine/S-1
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Gachon University Gil Medical Center
Prevention, LARS - Low Anterior Resection Syndrome
Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)
The main aim of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LAR syndrome in patients after mini-invasive rectal resection.
- Conditions
- Prevention, LARS - Low Anterior Resection Syndrome, Pelvic Floor Disorders, Rectal Cancer
- Trial name
- CH1 (NCT06519006)
- Testing
- Pelvic floor exercise
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- F. D. Roosevelt University Hospital
Metastatic Colorectal Cancer
LONsurf and G-CSF Use: Being On A Right Dose-intensity to Optimize Treatment Efficacy
Prospective cohort of patients treated with trifluridine/tipiracil, maximal sample size 250 patients. It is expected, that 89 patients will experience a grade 3-4 neutropenia and will be included in the phase II.
- Trial name
- LONGBOARD (NCT04166604)
- Testing
- Trifluridine/Tipiracil
- Where
- 22 sites in France
- Volunteers
- 176 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Rectal Cancer, Lymph Node Metastasis
Clinical Relevance of Pathologic Regression IN Lymph Node for Locally Advanced Rectal Cancer
We evaluated all related clinical and pathologic data of patients with Locally Advanced Rectal Cancer following Neoadjuvant Chemoradiotherapy, including the pathologic regression grading in the primary tumor site and lymph node…
- Trial name
- NCT06883084
- Volunteers
- 1,080 people
- Sponsor
- Yanhong Deng
Neoplasms
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022.
- Trial name
- NCT02817633
- Testing
- TSR-022, Nivolumab, TSR-042
- Where
- 89 sites in United States, South Korea and 1 more
- Volunteers
- 463 people
- Sponsor
- Tesaro, Inc.
Natural Orifice Specimen Extraction Surgery, Middle Rectal Cancer
Robotic Natural Orifice Specimen Extraction Surgery Compared to Robotic Assisted Surgery for Median Rectal Cancer
The purpose of this study is to evaluate the short-term outcomes of roboric natural orifice specimen extraction surgery (NOSES-II) compared to conventional assisted robotic surgery in the treatment of median rectal cancer.
- Conditions
- Natural Orifice Specimen Extraction Surgery, Middle Rectal Cancer, Robotic, Short-term Outcomes
- Trial name
- NCT06454201
- Testing
- robotic natural orifice specimen extraction surgery, robotic transabdominal specimen extraction surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanchang University
Rectal Neoplasms, Prognosis
Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer
Rectal cancer (RC) is among the most prevalent gastrointestinal cancers [1], characterized by significant tumor heterogeneity [2].
- Trial name
- NCT07269912
- Testing
- intravoxel incoherent motion magnetic resonance imaging
- Volunteers
- 400 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Genetic Testing, Breast Cancer
Video Education With Result Dependent dIsclosure
The overall study objective of this trial study is to identify and evaluate strategies to improve the accessibility of the video education with result dependent disclosure (VERDI) model, increasingly utilized as a pre-genetic…
- Conditions
- Genetic Testing, Breast Cancer, Ovarian Cancer, Pancreatic Cancer
- Trial name
- VERDI (NCT05225428)
- Testing
- Video Education, Genetic Counseling
- Where
- United States
- Volunteers
- 1,334 people
- Sponsor
- Dana-Farber Cancer Institute
Metastatic Colorectal Cancer
A Phase II Randomized Therapeutic Optimization Trial for Subjects With Refractory Metastatic Colorectal Cancer Using ctDNA: Rapid 1 Trial
This randomized, phase 2 study will investigate the use of the Signatera ctDNA assay versus the standard scan-based approach to guide treatment in patients with metastatic colorectal cancer.
- Trial name
- NCT04786600
- Testing
- Signatera ctDNA assay, pre-specified sequence of FDA-approved drugs and drug combinations
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Metastatic Colorectal Cancer
Sequences Of REGorafenib And Trifluridine/Tipiracil in Patients With Metastatic Colorectal Cancer
A randomized, phase II study comparing the sequences of regorafenib and trifluridine/tipiracil, after failure of standard therapies in patients with metastatic colorectal cancer
- Trial name
- SOREGATT (NCT04450836)
- Testing
- Regorafenib then Trifluridine/Tipiracil, Trifluridine/Tipiracil then Regorafenib
- Where
- 36 sites in Belgium, France
- Volunteers
- 234 people
- Sponsor
- UNICANCER