Clinical trials: RECURRENT PREGNANCY LOSS
Maternal-Fetal KIR-HLA-C Compatibility
PREDICTIVE IMMUNOLOGICAL STUDY OF RECURRENT ABORTIONS AND IMPLANTATION FAILURE
The involvement of the immune system in the process of implantation and its modulation as a therapeutic line in these alterations, failure of implantation and repetition abortion are controversial and make it necessary to conduct…
- Trial name
- NCT04052438
- Testing
- HLA-C and KIR determination for patients, couples, oocyte or semen donors, abortive tissue and newborn.
- Volunteers
- 200 people
- Sponsor
- IVI Madrid
Infertility, Female, Miscarriage
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.
- Conditions
- Infertility, Female, Miscarriage, Miscarriage, Recurrent, IVF
- Trial name
- NCT05969574
- Testing
- Transvaginal ultrasound, Blood test AMH
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 2,059 people
- Sponsor
- ART Fertility Clinics LLC
Recurrent Miscarriage
The Role of Prothrombin Gene and Methylenetetrahydrofolate Reductase(MTHFR) Gene Polymorphisms as Risk Factors for Recurrent Miscarriage
Recurrent miscarriage is a pregnancy loss before 20 weeks of gestation. The recurrent pregnancy loss(RPL) usually occurring in the first trimester of gestation and its rate is quite high (15-20% even in full reproductive period)…
- Trial name
- NCT03209063
- Testing
- polymerase chain reaction
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Assiut University
Recurrent Pregnancy Loss, Not Pregnant, Vaginal Microbiome
Uterine Microbiome in Recurrent Pregnancy Loss
The female genital tract microbiome may reflect female reproductive health and may be related to pregnancy outcomes. Disturbances in this microbiome may be associated with adverse reproductive outcomes.
- Trial name
- NCT05510622
- Testing
- Vaginal swab and endometrial biopsy
- Where
- 2 sites in Vietnam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Abortion, Habitual
LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss
The goal of this randomized, double-blind, placebo-controlled clinical trial is to evaluate whether levothyroxine supplement improves pregnancy outcomes in women with recurrent pregnancy loss (RPL) and isolated maternal…
- Trial name
- LIGHT (NCT06999278)
- Testing
- Levothyroxin
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant
This pilot clinical trial studies mechanical stimulation in preventing bone density loss in patients undergoing donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01558778
- Testing
- management of therapy complications, musculoskeletal complications management/prevention
- Sponsor
- Roswell Park Cancer Institute
Septate Uterus, Recurrent Pregnancy Loss
Hysteroscopic Septoplasty by Different Modalities
The goal of this clinical trial is to compare in participant population ( women with uterine septum meeting the inclusion criteria) hysteroscopic septoplasty by resectoscope compared to hysteroscopic septoplasty with scissors.
- Conditions
- Septate Uterus, Recurrent Pregnancy Loss, Subfertility
- Trial name
- NCT05802784
- Testing
- Hysteroscopic septoplasty with scissors, Hysteroscopic septoplasty with resectoscope
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Hospital
Recurrent Pregnancy Loss(RPL)
Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses
Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation.
- Trial name
- NCT06604338
- Testing
- Exome test, Microbiota analysis
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Abortion, Habitual, Infertility Unexplained
Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History
The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.
- Conditions
- Abortion, Habitual, Infertility Unexplained, Embryo Implantation, Pre-Eclampsia
- Trial name
- NCT06821685
- Testing
- autologous decidual-like NK cells
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recurrent Pregnancy Loss Without Current Pregnancy
HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss
Up to half of all cases of recurrent pregnancy loss are unexplained (uRPL). Evidence points towards endometriosis and progesterone resistance as an underlying cause of uRPL.
- Trial name
- HOPE (NCT05365464)
- Testing
- Progesterone Pill, hCG
- Sponsor
- Wake Forest University Health Sciences
Female Infertility, Reproductive Disorders
Effect of Comprehensive Spa Rehabilitation on Female Infertility: A Clinical Study in Adult Women (Infertility-Spa)
This is a prospective, single-arm, pretest-posttest study evaluating the effects of a 21-day comprehensive spa treatment (Komplexní lázeňská léčebně rehabilitační péče, KLP) on female infertility at spa facility in Františkovy…
- Conditions
- Female Infertility, Reproductive Disorders, Recurrent Pregnancy Loss
- Trial name
- NCT07542600
- Testing
- Comrehensive Spa Treatment (KLP)
- Where
- Czechia
- Volunteers
- 55 people
- Sponsor
- Institute of Spa and Balneology, public research institution
Miscarriage, Recurrent, Abortion, Habitual
Intravenous Immunoglobulin (IVIG) for Treatment of Unexplained Secondary Recurrent Miscarriage
Recurrent miscarriage is a prevalent reproductive problem that affects many couples who are trying to establish a family. This clinical study will evaluate the effectiveness of intravenous immunoglobulin (IVIG) in improving the…
- Trial name
- NCT00606905
- Testing
- Gamimune N or Gamunex 10%, normal saline
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Chicago
Habitual Abortion
Use of G-CSF for the Treatment of Unexplained Recurrent Miscarriage
In order to investigate the effectiveness of G-CSF in preventing embryo demise, the investigators administered this cytokine to women with recurrent miscarriage in a randomized controlled study compared to women treated with…
- Trial name
- NCT00772122
- Testing
- G-CSF, saline solution
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Florence
Recurrent Pregnancy Loss
Establishment of Special Disease Cohort for RPLand Study of Impact Mechanism of Early Embryo Development
Recurrent pregnancy loss (RPL) is a refractory disease with diverse etiologies, complex pathogenesis and limited therapeutic options. Current tests and treatments lack uniform specifications.
- Trial name
- NCT05186207
- Testing
- abnormal pre-pregnancy test results that need clinical intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Recurrent Pregnancy Loss
Genomic Predictors of Recurrent Pregnancy Loss
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.
- Trial name
- GPRPL (NCT05444283)
- Where
- 10 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
NSCLC Adenocarcinoma, Gastroesophageal Cancer (GC)
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
This is a multicenter clinical study to evaluate the safety, efficacy, and Pharmacokinetics (PK) of IDE892 as monotherapy and in combination with other agents including IDE397 in participants with methylthioadenosine…
- Conditions
- NSCLC Adenocarcinoma, Gastroesophageal Cancer (GC), Gastric Adenocarcinoma, Adenocarcinoma of Esophagus
- Trial name
- NCT07277413
- Testing
- IDE892, IDE397
- Where
- 23 sites in United States
- Volunteers
- 260 people
- Sponsor
- IDEAYA Biosciences
Secondary Recurrent Miscarriage
Trial of the Efficacy of Intravenous Immunoglobulin for Treating Women With Unexplained Secondary Recurrent Miscarriage
The investigators want to test whether infusions of intravenous immunoglobulin - a blood product known to modify immune responses - in early pregnancy will increase the chance of a subsequent live birth in women with three or…
- Trial name
- NCT00722475
- Testing
- Intravenous immunoglobulin, Human albumin
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Recurrent Pregnancy Loss
On Pregnancy After Losses - OPAL Study
Rationale: Recurrent pregnancy loss (RPL) is defined as the loss of two or more conceptions before the fetus reaches viability. It affects 1-3% of all fertile couples and despite extensive diagnostic work-up, in only around 30%…
- Trial name
- OPAL (NCT05167812)
- Testing
- Observation of pregnancies after intake
- Volunteers
- 1,931 people
- Sponsor
- Leiden University Medical Center
Infertility, Recurrent Pregnancy Loss
TNFα and MFG-E8: Novel Biomarkers to Predict Implantation Failure
Question: Can implantation failure (IF) be predicted prior to in vitro fertilization (IVF)? A pilot, non-interventional, clinical study Prospective, controlled, cohort study
- Trial name
- NCT02386384
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Recurrent Pregnancy Loss
Effectiveness of Aspirin in Compare With Heparin Plus Aspirin in Recurrent Pregnancy Loss Treatment
This study evaluated the effect of anticoagulant treatment on the live-birth rate in women with a history of at least two continuous unexplained miscarriages or thrombophilia.
- Trial name
- NCT01542411
- Where
- Iran
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Yazd Medical University