Clinical trials: REM Behavior Disorder
Parkinson Disease, Parkinsonism
Prodromal and Overt Parkinson's Disease Epidemiological Study in Brazil
Parkinson's Disease (PD) affects people universally, including all ethnic and socioeconomic groups, as a highly prevalent neurodegenerative disorder.
- Trial name
- PROBE-PD (NCT05677529)
- Where
- 4 sites in Brazil
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Parkinson Disease, Multiple System Atrophy
Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease
To determine whether retinal abnormalities, as measured by high definition optical coherence tomography (HD-OCT) and visual electrophysiology techniques can be used as a clinical biomarker to monitor disease progression overtime…
- Conditions
- Parkinson Disease, Multiple System Atrophy, REM Sleep Behavior Disorder, Pure Autonomic Failure
- Trial name
- NCT02640339
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Parkinson's Disease, REM Sleep Behavior Disorder
Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder
Up to 60% of Parkinson's Disease (PD) patients suffer from REM sleep behavior disorder (RBD), a parasomnia. This disorder is thought to be related to a dysfunction of limbic system and brainstem.
- Trial name
- MP-TCSP-IRMf (NCT02824341)
- Testing
- fMRI
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
REM Sleep Behavior Disorder, Synucleinopathies
A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBD
Comprehensive characterization of early-stage Parkinson's disease in patients with REM sleep behavior disorder Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder worldwide, significantly affecting quality…
- Conditions
- REM Sleep Behavior Disorder, Synucleinopathies, Parkinson's Disease (PD), Prodromal Parkinson's Disease
- Trial name
- 7T-RBD (NCT07790744)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
REM Sleep Behavior Disorder
Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease
With the global ageing population, neurodegenerative disorders including synucleinopathy are major burdens to patients, carers and society.
- Trial name
- NCT03645226
- Testing
- Colonoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
REM Sleep Behaviour Disorder
Microstructural and Sodium 7 Tesla Brain MRI in Idiopathic REM Sleep Behaviour Disorder
By 2030 the number of patients with Parkinson's Disease (PD) would increase by 56% affecting 1 out of 120 people older than 45 years-old.
- Trial name
- SODISLEEP (NCT05976971)
- Testing
- 7T MRI
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium Stage 2
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies
- Trial name
- NAPS2 (NCT05826457)
- Where
- 9 sites in United States, Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
REM Sleep Behavior Disorder, Healthy
Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is characterized by nocturnal violence, increased muscle tone during REM sleep and the lack of any other neurological disease.
- Trial name
- ALICE (NCT03072940)
- Testing
- Clinical investigations
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Gut Microbiota
Gut Microbiota in Major Depressive Disorders With and Without Rapid Eye Movement Behavior Disorder
The purpose of this study is to identify the variations in gut microbiota compositions between two subtypes of major depressive disorder.
- Trial name
- NCT05008120
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
REM Sleep Behavior Disorder, Neurodegenerative Diseases
Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration
Background: Previous studies have confirmed that most patients with idiopathic REM sleep behaviour disorder (iRBD) eventually develop neurodegenerative diseases.
- Trial name
- NCT03353207
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Narcolepsy, REM Sleep Behavior Disorder
Investigation of Clinical Feature and Brain Function in Narcoleptic Patients
This study evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD
- Trial name
- NCT03376568
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Idiopathic REM Sleep Behavior Disorder, Parkinson Disease
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual
This study aims to characterize neurodegeneration progression in patients with polysomnography (PSG)-confirmed longstanding idiopathic REM sleep behavior disorder (iRBD) and to develop a prognostic model for clinical evolution…
- Conditions
- Idiopathic REM Sleep Behavior Disorder, Parkinson Disease, Neurodegeneration, Prodromal Parkinson Disease
- Trial name
- iRBD (NCT07729748)
- Testing
- Multiparametric clinical, neuropsychological, PSG and MRI assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Parkinson Disease, REM Sleep Behavior Disorder
Detecting Parkinson's Disease Through Speech Analysis
Speech is an important indicator of motor function and movement coordination and can be extremely sensitive to involvement in the course of neurologic diseases.
- Trial name
- NCT03133611
- Testing
- Speech assessment, Routine clinical assessment
- Where
- 7 sites in United States, Austria and 5 more
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Neurodegenerative Diseases, Parkinson Disease
Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
It is not known what causes Parkinson's disease and what makes it worsen over time. Research conducted in the past few years has highlighted the possible role of inflammation on this process but its actual mechanisms are still…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT05205291
- Testing
- Lipopolysaccharide, PET/MR with [11C]PBR28
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Parkinson Disease, Multiple System Atrophy
A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
This will be an observational study looking at clinical and biomarker characteristics in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Rapid Eye Movement Sleep Behavior Disorder (RBD), Normal Pressure…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Rapid Eye Movement Sleep Behavior Disorder, Normal Pressure Hydrocephalus
- Trial name
- NCT04020198
- Testing
- Biomarker assay
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Parkinsonism, REM Sleep Behavior Disorder
A Multimodal Prospective Cohort Study of Parkinsonism
This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach.
- Trial name
- NCT07553845
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Dementia With Lewy Bodies, Parkinson Disease
5-HT RBD REM Sleep Behavior Disorder
This project will test the hypotheses that people with 5-HT RBD have systemic alpha- synuclein pathology, prodromal DLB signs, and brainstem lesions in regions that control REM sleep.
- Conditions
- Dementia With Lewy Bodies, Parkinson Disease, REM Sleep Behavior Disorder
- Trial name
- NCT06467461
- Testing
- Skin biopsy, Speech testing, Ultra high field 7T MRI
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Minnesota