Clinical trials: RENAL INSUFFICIENCY, CHRONIC
Chronic Kidney Disease
Pulsed Perfusion for Marginal Kidneys
Trends in organ donor pool are characterized by an increasing age and a shift towards cerebrovascular diseases as primary causes of death.
- Trial name
- PREDICTION (NCT02055950)
- Testing
- Storage of kidney in refrigerated solution, Kidney perfused by pulsatile machine
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Kidney Failure, Chronic, Cardiovascular Disease
Hydroxychloroquine in Cardiovascular Disease in Patients With Chronic Kidney Disease: A Proof of Concept Study
Presence of multiple traditional and nontraditional risk factors of atherosclerosis and cardiovascular disease (CVD) including inflammation in patients with chronic kidney disease (CKD) contribute to high CVD morbidity and…
- Conditions
- Kidney Failure, Chronic, Cardiovascular Disease, Arteriosclerosis
- Trial name
- NCT01537315
- Testing
- Hydroxychloroquine
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Arkansas
Chronic Kidney Diseases, Inflammation
Propolis for Patients With Chronic Kidney Disease.
To evaluate the effects of propolis extract on inflammation in participants with chronic kidney disease. Specific objectives To assess before and after the intervention period: The expression of transcription factors (nuclear…
- Trial name
- NCT04411758
- Testing
- Propolis
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Universidade Federal Fluminense
End Stage Renal Disease, Inflammation
Influence of the Vitamine E Coated Dialyzer on Inflammation and Anemia
Evaluation of the effect of a vitamin E coated high flux polysulfone dialyzer on the inflammatory state of patients' end stage renal disease and its clinical benefits in terms of anemia Objectives : To assess the benefits of a…
- Trial name
- EVIA (NCT03218865)
- Testing
- VIE high flux dialyzer, Leoceed H high flux dialyzer
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hemotech
End Stage Renal Disease (ESRD)
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
This study will identify which regions on the genes, and genes themselves, may account for an increased risk of end stage renal disease (ESRD), that is, near-total loss of kidney function, for people of African American descent.
- Trial name
- NCT00559767
- Where
- United States
- Volunteers
- 2,860 people
- Sponsor
- National Cancer Institute (NCI)
IGA Nephropathy
Mycophenolate Mofetil for IgA Nephropathy
IgA nephropathy (IgAN) is the commonest primary glomerulonephritis worldwide. In Hong Kong, IgAN accounts for approximately 30% of all primary glomerular diseases, and a significant proportion of young patients (< 50 years of…
- Trial name
- NCT00863252
- Testing
- mycophenolate mofetil, angiotensin blockade
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Kidney Failure, Chronic
Low-frequency Electrical Muscle Stimulation vs Cycle Training During Haemodialysis
The purpose of the trial is to compare the effects of intra-dialytic low-frequency electrical muscle stimulation and intra-dialytic cycling, with usual care haemodialysis without exercise training.
- Trial name
- NCT02874521
- Testing
- Intra-dialytic LF-EMS, Intra-dialytic cycle training
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Chronic Kidney Disease Stage 5 (Dialysis Dependent)
A Randomized, Comparative, Open-label Study of IV Monofer® Administered as Maintenance Therapy by Single or Repeated Bolus Injections in Comparison With IV Iron Sucrose in Subjects With CKD-5D
The purpose of this study is to compare the efficacy and safety of intravenous iron isomaltoside 1000 with intravenous iron sucrose in patients suffering from Stage 5 Chronic Kidney Disease on Dialysis Therapy (CKD-5D).
- Trial name
- NCT01222884
- Testing
- Monofer, Iron sucrose
- Where
- India
- Volunteers
- 351 people
- Sponsor
- Pharmacosmos A/S
Quality of Life, End Stage Renal Disease
Improved Selection of Elderly (> 65 Years) for Kidney Transplantation
Kidney transplantation has been shown to provide improved survival even in patients older than 70 years of age. The purpose of the study is to determine whether kidney transplantation provides any improvement of health related…
- Conditions
- Quality of Life, End Stage Renal Disease, End Stage Renal Failure on Dialysis
- Trial name
- QUESTION65 (NCT01760733)
- Where
- Norway
- Volunteers
- 289 people
- Sponsor
- Sykehuset Telemark
End Stage Renal Failure, Hemodialysis, Vascular Access
Comparison of Tunneled Cuffed Dialysis Catheters Versus Arteriovenous Fistulae in Elderly or Multimorbid Patients
Patients are randomly assigned to a study group. Depending on the study group, either an arteriovenous fistula or tunneled cuffed catheter (TCC) will be implanted, followed by continuous evaluation of the patients during the…
- Conditions
- End Stage Renal Failure, Hemodialysis, Vascular Access, Fistulas Arteriovenous, Haemodialysis Complication
- Trial name
- NCT07649083
- Testing
- Tunneled cuffed catheter (TCC) will be implanted for chronic haemodialysis treatment, Arteriovenous fistula creation for chronic haemodialysis treatment
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Hemodialysis, Chronic Kidney Disease
Comparison of Body Hydration State in Hemodialysis Patients
Estimation of hydration state in dialysis patients is a major challenge in clinical practice. Although many methods have been studied, none have been established yet for clinical routine practice.
- Trial name
- NCT01814254
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Renal Research Institute
Chronic Kidney Disease Stage 3
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age With Chronic Kidney Disease (CKD)
The goal of this clinical trial is to learn about the safety (good or bad) of giving two AION-301 intravenous (IV) infusions, in adults with Stage 3 Chronic Kidney Disease (CKD).
- Trial name
- UC-MSC-CKD (NCT06721143)
- Testing
- AION-301
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- AION Healthspan, Inc.
Chronic Kidney Disease
Nicotinamide Riboside Supplementation in Chronic Kidney Disease
This study is testing whether a dietary supplement called nicotinamide riboside, (NR), can be used in adults with moderate chronic kidney disease. NR is a form of vitamin B3 that may help support cellular energy metabolism.
- Trial name
- NR-CKD (NCT07693543)
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Diabetic Kidney Disease, Diabetic Nephropathies
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03840343
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
ESRD
Experience of Patients Starting Hemodialysis
Patients starting dialysis have significant and often daunting changes to their lifestyle, and investigators have only little information from the patient perspective on patient experiences during dialysis initiation.
- Trial name
- NCT04988568
- Testing
- None. This is a qualitative interview study.
- Where
- 17 sites in United States
- Volunteers
- 20 people
- Sponsor
- Satellite Healthcare
End-stage Renal Disease
Effects of Oral Sodium Bicarbonate Supplementation in Haemodialysis Patients (BicHD)
The purpose of the study is to investigate whether oral sodium bicarbonate supplementation to ensure a constant bicarbonate profile in haemodialysis patients will primarily lower predialysis potassium levels and secondary lead to…
- Trial name
- BicHD (NCT02692378)
- Testing
- sodium bicarbonate 500mg capsules
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College Healthcare NHS Trust
Atrial Fibrillation, Chronic Kidney Disease
The Effects of Renal Function and Atrial Fibrillation on Lipoproteins and Clot Structure/Function
This study is designed to investigate the role of lipids/lipoproteins as a potential cause for the harmful changes seen in fibrin clot properties with renal dysfunction and atrial fibrillation
- Trial name
- RALiC (NCT04043026)
- Testing
- Statin
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Liverpool
End Stage Renal Disease (ESRD), Kidney Disease
RaDIANT Health Systems Intervention
The overarching goal of the proposed study is to determine whether the addition of structural interventions at the health system level targeting upstream barriers in the transplant process will improve access to transplant…
- Trial name
- NCT07033117
- Testing
- Performance Feedback Reports on Referral and Evaluation Closures, Dialysis Facility Awareness Campaign, Patient Contact via Preferred Method
- Where
- 5 sites in United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Renal Failure Chronic
Immunotherapy of Chronic Kidney Failure
Kidney failure can result from inflammatory renal disease in the context of autoimmunity because the kidney is targeted by host's immune response against self.
- Trial name
- NCT04377243
- Testing
- V8
- Where
- Mongolia
- Volunteers
- 20 people
- Sponsor
- Immunitor LLC
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