Clinical trials: RENAL INSUFFICIENCY, CHRONIC
Healthy Volunteers, Chronic Kidney Disease
A Study of RBT-3 in Healthy Volunteers and Volunteers With Stage 3/4 Chronic Kidney Disease
This is a Phase 1b, single center, dose-escalating study evaluating the safety, tolerability, and pharmacodynamic effect of RBT-3 in healthy volunteers and in subjects with stage 3-4 chronic kidney disease.
- Trial name
- NCT04072432
- Testing
- RBT-3
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Renibus Therapeutics, Inc.
Chronic Kidney Disease
Low-protein Formula Supplements in Chronic Kidney Disease
Prospective randomized contorl study.Comparing clinical outcome between chronic kidney disease who were prescribed 6% low-protein nutrition supplement along with dietatian regular nutrition education and those without oral…
- Trial name
- NCT05318014
- Testing
- Intervention group, Regular nutrition education
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- Taichung Veterans General Hospital
End Stage Renal Disease, Left Ventricular Hypertrophy
Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study
Kidney patients on dialysis commonly die because of heart disease. One of the biggest problems in their hearts is that the muscle wall of the heart thickens. This makes it less efficient.
- Trial name
- Altered (NCT01951404)
- Testing
- Allopurinol
- Where
- 3 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Dundee
Chronic Kidney Disease, Congestive Heart Failure
Peritoneal Ultrafiltration to Treat Congestive Heart Failure
The purpose of this study is to determine whether the treatment of peritoneal ultrafiltration can improve survival and quality of life of refractory congestive heart failure with special accent on preserving residual renal…
- Trial name
- NCT02829450
- Testing
- peritoneal ultrafiltration
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
Chronic Kidney Disease, Type 2 Diabetes
Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease
This study assesses the effects of bardoxolone methyl (RTA 402) in patients with type 2 diabetes and chronic kidney disease.
- Conditions
- Chronic Kidney Disease, Type 2 Diabetes, Diabetic Nephropathy
- Trial name
- NCT00811889
- Testing
- Bardoxolone Methyl (RTA 402)
- Where
- 42 sites in United States
- Volunteers
- 227 people
- Sponsor
- Biogen
Chronic Kidney Disease (CKD), Kidney Transplant
Remote vs In-Person Prehabilitation for Kidney Transplant Candidates
Patients with advanced chronic kidney disease awaiting deceased-donor kidney transplantation frequently experience progressive functional decline, frailty, reduced mobility, and poor quality of life while on the transplant…
- Conditions
- Chronic Kidney Disease (CKD), Kidney Transplant, Frailty, Prehabilitation
- Trial name
- KIDFIT (NCT07701382)
- Testing
- In-Person Multimodal Prehabilitation, Remote Multimodal Prehabilitation
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Clinic of Barcelona
End-stage Renal Disease
French Renal Epidemiology and Information Network (REIN) Registry
The Renal Epidemiology and Information Network (REIN) Registry was created in 2002 (after study pilot in 2001) to contribute to the development and evaluation of health strategies aiming at improving prevention and management of…
- Trial name
- REIN-LOR (NCT03967808)
- Where
- France
- Volunteers
- 6,000 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Kidney Disease
A Cluster Randomized Trial to Assess the Impact of Patient and Provider Education on Use of Home Dialysis
Patients with severe kidney failure require dialysis or transplantation to survive. For those in whom a transplant is not an option, there are two main dialysis options: hemodialysis (either incenter or at home) or home…
- Trial name
- NCT02202018
- Testing
- Active KT intervention
- Where
- 2 sites in Canada
- Volunteers
- 55 people
- Sponsor
- University of Calgary
End Stage Renal Disease
A Comparison of Physical Activity Levels With and Without Feedback Via Fitbit® Flex™ in Hemodialysis Patients
This is a pilot study intended to gather data in order to inform future studies about the role of feedback as an incentive for increasing levels of physical activity which could improve health in hemodialysis patients.
- Trial name
- IAM (NCT02320513)
- Testing
- Wearing activty monitoring device (Fitbit Flex), Fitbit Flex
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Renal Research Institute
End Stage Renal Disease, Endothelial Dysfunction
Cocoa Flavanols in Renal Disease
Purpose of the study is to characterize the potential acute and long-term improvement of dietary flavanols on vascular function in patients with end-stage renal disease (ESRD).
- Trial name
- NCT01412320
- Testing
- Cocoa
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Chronic Kidney Disease
The Role of P-cresol and Related Protein Fermentation Metabolites in Chronic Kidney Disease Patients
Study on the natural history of uremic retention solutes in patients with mild-to-moderate chronic kidney disease
- Trial name
- NCT00441623
- Testing
- observational
- Where
- Belgium
- Volunteers
- 499 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
End-Stage Kidney Disease
Incremental Hemodialysis: The TwoPlus Trial
This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney…
- Trial name
- NCT05828823
- Testing
- Hemodialysis twice weekly, Hemodialysis thrice weekly
- Where
- 10 sites in United States
- Volunteers
- 350 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes
Chronotherapy with Low-dose Aspirin for Primary Prevention
Brief summary: Aspirin (ASA) has been shown to provide marked benefits in primary and secondary prevention of cardiovascular events.
- Trial name
- CARING (NCT00725127)
- Testing
- aspirin
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hyperparathyroidism, Secondary, Kidney Failure, Chronic
Hyperparathyroidism and Dialysis Adequacy in Hemodialysis Patients
This cross-sectional study aims to determine the prevalence of secondary hyperparathyroidism among end-stage renal disease patients on regular hemodialysis and to evaluate its relationship with dialysis adequacy at Assiut…
- Conditions
- Hyperparathyroidism, Secondary, Kidney Failure, Chronic, Chronic Kidney Diseases
- Trial name
- NCT07820150
- Volunteers
- 130 people
- Sponsor
- Assiut University
Cancer Pain, Renal Insufficiency Chronic
Assessing Hydromorphone Sustained-Release Tablets in Elderly Cancer Pain Patients With Renal Insufficiency
This clinical study aims to understand whether domestic hydromorphinone sustained-release tablets are effective and safe in treating moderate to severe cancer pain in elderly patients with renal insufficiency.
- Conditions
- Cancer Pain, Renal Insufficiency Chronic, Hydromorphone Use
- Trial name
- NCT07421674
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Taian Cancer Hospital
Chronic Renal Failure With Uremic Nephropathy
Studies in Patients With Multiple Myeloma and Renal Failure Due to Myeloma Cast Nephropathy
MYRE is a phase III multicentric controlled national clinical trial conducted in patients with multiple myeloma and renal failure related to myeloma cast nephropathy (MCN).
- Trial name
- MYRE (NCT01208818)
- Testing
- Cyclophosphamide + Bortezomib + Dexamethasone regimen, Bortezomib +Dexamethasone regimen, HCO group
- Where
- France
- Volunteers
- 284 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anemia in Incident Dialysis Patients
Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants
The purpose of this study is to determine whether roxadustat is safe and effective in the treatment of anemia in participants who have just begun dialysis treatment for ESRD.
- Trial name
- Himalayas (NCT02052310)
- Testing
- Roxadustat, Epoetin Alfa
- Where
- 113 sites in United States, Argentina and 13 more
- Volunteers
- 1,043 people
- Sponsor
- Kyntra Bio
Chronic Kidney Disease Associated Moderate to Severe Pruritus
To Evaluate the Efficacy and Safety of Nemolizumab for 12 Weeks in Participants With Chronic Kidney Disease With Associated Moderate to Severe Pruritus
The purpose of this study was to evaluate the efficacy of nemolizumab compared to placebo at reducing the intensity of pruritus after a 12-week treatment period in adult hemodialysis participants with moderate to severe pruritus.
- Trial name
- NIKAIA 1 (NCT05075408)
- Testing
- Nemolizumab
- Where
- 64 sites in United States, Hungary and 2 more
- Volunteers
- 258 people
- Sponsor
- Galderma R&D
Chronic Kidney Diseases, Metabolic Syndrome
Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease
The pilot study will adopt a 2-arm, pretest-posttest, and assessor-blind randomized controlled trial design to examine the feasibility and acceptability of a theory-based health behaviour change intervention and examine its…
- Trial name
- NCT06527768
- Testing
- Theory-based health behaviour change interventio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
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