Clinical trials: Radiation Dosage
Prostate Cancer
High Dose Rate Prostate Brachytherapy as Salvage for Locally Recurrent Prostate Cancer Previously Treated With External Beam Radiotherapy
High dose rate (HDR) brachytherapy is a form of radiation treatment using temporary radioactive seeds. This is done by placing very tiny catheters or tubes into the prostate and then inserting temporary radioactive seeds, called…
- Trial name
- NCT00604526
- Testing
- High dose rate (HDR) brachytherapy using Iridium 192 radioactive seeds
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Spinal Cord Compression From Neoplasm Metastasis
SuperDEX Trial (Comparison of Two Doses of Dexamethasone for Malignant Spinal Cord Compression Treated by Radiotherapy).
The study aimed to pilot the viability of a full scale randomised comparison of 2 steroid doses in malignant spinal cord compression, to establish safety of high dose dexamethasone in this setting in Australia, to test web…
- Trial name
- NCT00193869
- Testing
- Dexamethasone
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Advanced Squamous Cell Carcinoma
Radiotherapy Dose Escalation in Locally Advanced Squamous Cell Carcinoma of the Larynx or Hypopharynx
This is a phase 2 single arm study of a novel schedule of hyperfractionated radiotherapy (RT) in combination with our standard chemotherapy program for patients with stage 3-4 squamous cell carcinoma of the larynx.
- Trial name
- NCT03388931
- Testing
- Radiation Therapy, Chemotherapy
- Where
- United States
- Sponsor
- University of Florida
Non-Small-Cell Lung Carcinoma
Safety Study of Individualised Radiation Dose Determination for Lung Cancer Patients.
Radiotherapy is treatment of choice for inoperable lung cancer. Research has shown that the local control rate is low and the radiation often causes pneumonitis and/or esophagitis.
- Trial name
- NCT00181545
- Testing
- escalation of dose (radiotherapy treatment)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Maastricht Radiation Oncology
Mycosis Fungoides
Low Dose Total Skin Electron Beam Radiation Therapy and Mechlorethamine Hydrochloride Gel in Treating Patients With Mycosis Fungoides
This phase II trial studies how well low dose total skin electron beam radiation therapy and mechlorethamine hydrochloride gel work in treating patients with mycosis fungoides.
- Trial name
- NCT03288818
- Testing
- Mechlorethamine Hydrochloride Gel, Total Skin Electron Beam Radiation Therapy
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery
To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared to…
- Conditions
- Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Stroke
- Trial name
- CRICKET (NCT02173470)
- Testing
- CT scan
- Where
- 3 sites in Hungary, Netherlands
- Volunteers
- 866 people
- Sponsor
- UMC Utrecht
Heart Failure - NYHA II - IV
Low Dose Radiotherapy for Heart Failure
The primary goals of this clinical trial are to evaluate the safety and efficacy of a low dose whole-heart radiotherapy with a single fraction in ten participants with advanced heart failure.
- Trial name
- RadioCardio (NCT07037524)
- Testing
- Radiation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital do Coracao
Glioblastoma (GBM)
A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients
The purpose of the study is to determine the recommended dose and further understand the safety of MT-125 in participants who have been diagnosed with glioblastoma, a primary brain tumor, when administered in combination with…
- Trial name
- STAR-GBM (NCT07185880)
- Testing
- MT-125
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Myosin Therapeutics Inc.
Prostate Cancer, Radiotherapy
FLAME: Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer
Rationale: Dose escalation in external-beam irradiation has proven to benefit outcome in local prostate cancer. Randomized trials were performed up to doses of 78 Gy in 2 Gy fractions.
- Conditions
- Prostate Cancer, Radiotherapy, MRI
- Trial name
- FLAME (NCT01168479)
- Testing
- FLAME boost, standard arm
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 571 people
- Sponsor
- UMC Utrecht
Cystic Fibrosis
MR Imaging of Lung in the Follow-up Assessment of Cystic Fibrosis
The aim of the study is to assess the diagnostic sensitivity of MRI to detect changes in Helbich-Bhalla scoring over time in patients with cystic fibrosis
- Trial name
- CFMR-lung (NCT03357562)
- Testing
- lung MRI
- Where
- 11 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Prostate Cancer
Magnetic Resonance-Guided High-Dose Brachytherapy (Short-Range Radiation Therapy) for Prostate Cancer
This study will evaluate the use of magnetic resonance imaging (MRI) for guiding placement of hollow needles into the prostate gland for delivering internal radiation therapy to patients with prostate cancer.
- Trial name
- NCT00039624
- Testing
- Brachytherapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Cancer
Sphincter-preserving Surgery After Preoperative Treatment of Ultra-low Rectal Carcinoma
This phase III trial included patients with low rectal adenocarcinoma which initially required APR, with a mean clinical distance between the tumor inferior pole and the levator ani of 0.5 cm.
- Trial name
- GRECCAR1 (NCT00979680)
- Testing
- High-Dose radiotherapy, Chemo-radiotherapy
- Where
- 12 sites in France
- Volunteers
- 207 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cervix Cancer
CAmpto-CISplatine Plus Radiotherapy in Advanced Cervix Cancer : Search of Tolerated Maximum Dose of Campto
Search of maximum tolerated irinotecan dose in association with cisplatin and pelvic radiotherapy in patients with an advanced cervix cancer.
- Trial name
- NCT00251888
- Testing
- campto (irinotecan), cisplatin (cisplatyl)
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- ARCAGY/ GINECO GROUP
Head and Neck Cancer
InGReS: Intra-treatment Image Guided Adaptive Radiotherapy Dose-escalation Study
InGReS is a phase I pilot study of adaptive dose-escalated radiotherapy in combination with platinum-based chemotherapy (CRT) for locally advanced head and neck cancer.
- Trial name
- InGReS (NCT05393297)
- Testing
- Imaging: Intra-treatment FDG-PET-CT and MRI, Intra-treatment Image-Guided Adaptive Radiotherapy Dose-escalation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Mucositis, Solid Tumors
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
The purpose of this research study is to test the safety and effectiveness of palifermin to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity…
- Conditions
- Mucositis, Solid Tumors, Stomatitis, Head and Neck Cancer
- Trial name
- NCT00101582
- Testing
- palifermin, cisplatin chemotherapy, Radiotherapy
- Volunteers
- 188 people
- Sponsor
- Swedish Orphan Biovitrum
Brain Tumors, Central Nervous System Tumors
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Brain Stem Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003625
- Testing
- cyclosporine, etoposide, vincristine sulfate
- Where
- 74 sites in United States, Canada and 3 more
- Volunteers
- 7 people
- Sponsor
- Children's Oncology Group
Carcinoma, Hepatocellular, Colorectal Neoplasms
Early Biomarkers of Tumor Response in High Dose Hypofractionated Radiotherapy Word Package 3 : Immune Response
This study will follow-up immune cell populations, secreted factors and released nanovesicles in the blood before, during and after high dose radiation therapy which should give new information of the efficacy of the…
- Conditions
- Carcinoma, Hepatocellular, Colorectal Neoplasms, Melanoma, Kidney Neoplasms
- Trial name
- NCT02439008
- Testing
- Blood samples collection before radiotherapy, Blood samples collection during radiotherapy, Blood samples collection after radiotherapy
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Oscar Lambret
Prostate Cancer
A Study of MRI-guided High-dose Radiation Therapy in Prostate Cancer
One of the usual approaches to treating intermediate-risk prostate cancer is a type of radiation therapy called SBRT (stereotactic body radiation therapy).
- Trial name
- NCT04997018
- Testing
- Radiation Therapy
- Where
- 7 sites in United States
- Volunteers
- 91 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Non-Small-Cell Lung Carcinoma
Concurrent Helical Tomotherapy With Chemotherapy in Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)
This non-randomized Phase I/II study is designed to determine the maximum tolerated dose (MTD) of thoracic radiotherapy and concurrent chemotherapy with cisplatin and docetaxel in patients with LA-NSCLC.
- Trial name
- NCT00379717
- Testing
- Cisplatinum, Docetaxel, Tomotherapy
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Diffuse Large B Cell Lymphoma
Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma
This phase II study will evaluate whether a reduction in radiation dose and field size will maintain a high rate of local control while minimizing the risk of acute and late toxicity .
- Trial name
- DLBCL (NCT03681535)
- Testing
- Radiation Therapy
- Where
- 12 sites in United States, Czechia and 4 more
- Volunteers
- 243 people
- Sponsor
- Duke University