Clinical trials: Radiation Effects
Radiation; Adverse Effect, Pneumonitis
Predictors of Radiation Pneumonitis in Locally Advanced Lung Cancer Treated With Chemoradiation
Lung cancer [LC] is the leading cause of cancer death worldwide. The standard treatment of locally advanced lung cancer unresectable or marginally resectable is combination therapy with radical or preoperative chemoradiation.
- Trial name
- NCT01580579
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Thoracic Cancer, Left Sided Breast Cancer
Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
Patients enrolled in the study will receive standard of care adjuvant or definitive breast, chest wall or thoracic radiation therapy.Cardiac mitochondrial dysfunction is a hallmark of radiation-induced cardiac injury.
- Trial name
- NCT04044872
- Testing
- [1-13C]pyruvate along with MRI imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Melanoma, Effects of Immunotherapy
Trial of SBRT With Concurrent Ipilimumab in Metastatic Melanoma
The prognosis of advanced metastatic melanoma remains poor although a breakthrough has been achieved with the novel anti-CTLA-4 treatment (ipilimumab) for a subset of patients.
- Conditions
- Melanoma, Effects of Immunotherapy, Adverse Effect of Radiation Therapy
- Trial name
- NCT02406183
- Testing
- Stereotactic body radiotherapy (SBRT), Ipilimumab
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Radiotherapie
Radiotherapy, Immunology
Evaluation of the Immunological Effects of a Combined Treatment With Radiation and Cyclophosphamide in Metastasized Breast Cancer Patients
In metastasized of locally advanced breast cancer patients, local problems often occur like skin metastases, ulcerations or lymph node metastases.
- Trial name
- NCT02441270
- Testing
- Cyclophosphamide, Stereotactic body radiotherapy
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Erythema, Pain
Ultra Violet B Radiation (UVR) Study of Strontium Chloride Hexahydrate Hydrocortisone
Double blinded (subject and observer), randomised, active (hydrocortisone (HC)) controlled study of the effect of strontium chloride hexahydrate on ultraviolet B radiation (UVR) induced signs of inflammation (erythema and pain)…
- Trial name
- NCT01301677
- Testing
- Hydrocortisone, 2PX+, 2PX-
- Where
- 2 sites in Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- X-pert Med GmbH
Anal Carcinoma
Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy
Randomized study to investigate the efficacy of deep regional hyperthermia in patients with anal carcinoma treated by standard radiochemotherapy with MMC and 5-FU.
- Trial name
- HYCAN (NCT02369939)
- Testing
- Irradiation, Mitomycin C, 5-Fluorouracil
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Unrecognized Condition
Intravascular Laser Irradiation of Blood Use in Poor Ovarian Responders
The aim of this study was to investigate the effects of intravascular laser irradiation of blood on outcomes of in vitro fertilization cycles in poor ovarian responders.
- Trial name
- NCT05873075
- Testing
- Intravascular laser irradiation of blood
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Non-Small Cell Lung Cancer Without Mutation in Epidermal Growth Factor Receptor (Disorder)
To Explore the Effect of Immune-induced Stereotactic Body Radiotherapy (SBRT) on Reversing Immunoresistance in Stage IIIc/IV Non-small Cell Lung Cancer (NSCLC)
The goal of this clinical trial is to learn about in describe participant population. The main questions it aims to answer are: the outcomes of the efficacy (ORR) and safety (adverse events, including irAEs, AE, SAEs, and…
- Trial name
- NCT06154967
- Testing
- tereotactic body radiotherapy
- Volunteers
- 20 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Radiation- Induced Mucositis, Adverse Effect of Radiation Therapy
Prevention of Mucositis in Patients With Head and Neck Cancer Treated With Radiotherapy
Prevention of radiation-induced mucositis in patients with head and neck cancer treated with radiotherapy : A Double-blind Randomized Controlled Trial
- Conditions
- Radiation- Induced Mucositis, Adverse Effect of Radiation Therapy, Head and Neck Cancer
- Trial name
- NCT03359187
- Testing
- Normal saline with salt/Soda, Clinacanthus nutans, Boesenbergia rotunda
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Chulabhorn Hospital
Cancer, Cardiotoxicity
BIOMARKER and IMAGING CHARACTERISATION of INFLAMMATORY ATHEROMA in PATIENTS RECEIVING IMMUNOTHERAPY and ANGIOGENESIS INHIBITORS
The advent of immunotherapy (immune checkpoint inhibitors [ICI]) has been an extremely important advancement for cancer treatment in recent decades.
- Conditions
- Cancer, Cardiotoxicity, Atherosclerotic Disease
- Trial name
- BIOCAPRI (NCT06597045)
- Testing
- PET/CT with 18-FDG
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Breast Cancer, Fatigue
The Effect of Walking on Fatigue During Radiotherapy in Breast Cancer Patients 65 and Older
This multicenter randomized (1:1) phase 2 study is designed to assess the efficacy of the Walk with Ease exercise program on improving fatigue after adjuvant radiotherapy compared to usual care in 50 women with stage 0-3 breast…
- Trial name
- WWE (NCT02434367)
- Testing
- Walk With Ease Arm A
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- The West Clinic, Memphis
Patients Treated by Radiotherapy With < One Gy to the Brain
Long Term Neurocognitive Effects of Low-dose Radiation in the Brain: Study of 150 Patients in the French Hemangioma Cohort
Context: Studies that address specifically the neurocognitive consequences that can be caused by low-dose radiation receiving during the childhood have still to be performed.
- Trial name
- CogRad (NCT01960751)
- Testing
- neurocognitive tests battery
- Where
- France
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Thoracic Surgery, Ultrasonography
Lung Ultrasound as Alternative to Radiography in Thoracic Surgery
This projects aim is to study the effects of substitute conventional chest x-ray with lung ultrasound for patients undergoing thoracic surgery.
- Trial name
- LUS-ART (NCT06261411)
- Testing
- Lung Ultrasound
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Uppsala University Hospital
Preterm Infant, Body Composition
Effect of Tactile/Kinaesthetic Massage Therapy on DXA Parameter of Preterm Infants
The effect of Tactile/Kinaesthetic massage therapy on weight gain and different components of growth, as assessed by anthropometric measurements and DXA scan, and correlate these components with serum IGF-1, leptin and…
- Conditions
- Preterm Infant, Body Composition, Dual X-ray Absorptiometry (DXA) Scan
- Trial name
- NCT03412578
- Testing
- Massage Therapy
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University Children Hospital
Local Control Rate, Side Effect
Proton Beam Therapy for Unresectable Liver Metastasis
The investigators performed the present study to evaluate the role of proton beam therapy for liver metastasis which is unresectable and unsuitable for radiofrequency ablation (RFA) in terms of local control and safety.
- Trial name
- NCT04456621
- Testing
- PBT
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Healthy Volunteers
Transcranial Electrical Stimulation (TCES) / Cerebral Blood Flow (CBF) / Xenon Under Computerized Tomography (Xe/CT)
Direct stimulation of the cerebral cortex induces an increase in cerebral blood flow. Although this information is known, it has never been documented during Transcranial Cerebral Electrical Stimulation (TCES), which is a non…
- Trial name
- NCT00273663
- Testing
- TCES
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Breast Cancer, Surgery
Analgesic Effect of Resistance Training for Breast Cancer Survivors
Persistent pain after treatment for breast cancer is a major clinical problem, affecting 25-60 % of the patients and is a source of considerable physical disability and psychological distress.
- Conditions
- Breast Cancer, Surgery, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- (ANTRAC) (NCT04509284)
- Testing
- Training, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University
Head and Neck Squamous Cell Carcinoma
Effect of Accelerated RTH in Squamous Cell Carcinoma in Head and Neck
Evaluation of the efficacy of the accelerated radiotherapy in squamous cell carcinoma of head and neck
- Trial name
- NCT05291663
- Volunteers
- 100 people
- Sponsor
- Assiut University
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