Clinical trials: Radiation Induced Fibrosis
Breast Neoplasms, Radiation Pneumonia
Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort
Prospective cohort research to study the state of oxygen metabolism, reserve capabilities of cardiovascular and respiratory systems in patients with breast cancer to create a program of prevention and rehabilitation of lung…
- Conditions
- Breast Neoplasms, Radiation Pneumonia, Radiation Pneumonitis, Radiation Induced Fibrosis
- Trial name
- RELIEF-COHORT (NCT06069115)
- Testing
- Radiation therapy protocol for Breast cancer, Spirography and assessment of pulmonary diffusion capacity, Cardiopulmonary stress test
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Chronic Liver Disease (CLD), Cancer
Chronic Liver Disease and Radiation-induced Second Primary Liver Malignancy
Cancer survivors are at a high risk to develop second primary malignancy (SPM) which constitutes a serious threat for them. Radiotherapy is the cornerstone for the management of many cancers as a locoregional treatment modality.
- Conditions
- Chronic Liver Disease (CLD), Cancer, Liver Fibrosis
- Trial name
- NCT06868394
- Testing
- radiotherapy, No intervention
- Where
- Egypt
- Volunteers
- 20,846 people
- Sponsor
- Suez Canal University
Cardiotoxicity
Cardiac Fibrosis and Risk Prediction in Cancer Treatment-Related Cardiotoxicity
The purpose of this study is to determine whether pre-existing cardiac fibrosis is a predictor of cancer treatment-related cardiotoxicity.
- Trial name
- NCT02798679
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Esophageal Cancer, Radiation Pneumonitis
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology
Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs.
- Conditions
- Esophageal Cancer, Radiation Pneumonitis, Pulmonary Fibrosis, Respiratory Failure
- Trial name
- NCT03462524
- Testing
- Esophagectomy
- Where
- 2 sites in Ireland
- Volunteers
- 384 people
- Sponsor
- St. James's Hospital, Ireland
Head and Neck Squamous Cell Carcinoma
Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer
The purpose of this research is to assess the safety and evaluate the potential of the Multispectral Optoacoustic Tomography (MSOT) device to more precisely identify and assess the neck lymph nodes which might be affected in…
- Trial name
- OUSCCMOTORX (NCT06477003)
- Testing
- Multispectral Optoacoustic Tomography, Temperature Measurement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Breast Cancer, Lymphedema
Vitamin E and Pentoxifylline in Treating Women With Lymphedema After Radiation Therapy for Breast Cancer
RATIONALE: Vitamin E and pentoxifylline may be effective in decreasing lymphedema in women who have received radiation therapy for breast cancer.
- Trial name
- NCT00022204
- Testing
- vitamin E, pentoxifylline, quality-of-life assessment
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Fibrosis
Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen
The pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. Hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of…
- Trial name
- ORT-OXI-2009 (NCT01822405)
- Testing
- pentoxifylline with tocopherol, pentoxifylline+tocopherol + Hyperbaric Oxygen Therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario de Canarias
Breast Carcinoma, Fibrosis
RNA and Heat Shock Protein Biomarkers in Radiation-induced Fibrosis in Breast Cancer
The purpose of this study is to seeking a molecular signature of pathological radiation induced fibrosis based on the response of skin fibroblasts after irradiation, comparing two groups of patients distinguished by their…
- Trial name
- SPLICI-Rad (NCT03000764)
- Testing
- skin biopsies, blood samples
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut de Cancérologie de Lorraine
Radiation Induced Fibrosis to the Head and Neck
Study of Topical Superoxide Dismutase to Treat Radiation Induced Fibrosis
The purpose of this study is to determine if topical superoxide dismutase is an effective treatment of radiation related neck fibrosis, and to determine the quality of life impact from radiation related fibrosis in the head and…
- Trial name
- Sodermix (NCT01771991)
- Testing
- Topical Sodermix Dismutase in the form of Sodermix (SOD)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Sanford Health
Radiation Toxicity, Fibrosis
Pilot Study of the Predictive Value of TREM1 Expression and Activation in Inflammation and Radio-induced Mammary Fibrosis
Breast cancer is the most common cancer in the world. Half of patients with such cancer are treated with radiation therapy. Some patients will develop cutaneous or subcutaneous fibrosis, more or less bothersome.
- Conditions
- Radiation Toxicity, Fibrosis, Breast Cancer
- Trial name
- TREM-1 (NCT04948840)
- Testing
- Blood sampling
- Where
- 3 sites in France, Luxembourg
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse, Luxembourg
Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
The Evaluation of Manual Therapy for the Prevention of Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
The subjects in this study are the patients with head and neck cancer after completion of the radiotherapy. Radiation-induced fibrosis is inevitable and there is no effective treatment to prevent it.
- Trial name
- NCT04850170
- Testing
- manual therapy, Speech therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Interstitial Lung Disease, Idiopathic Interstitial Pneumonias
FAPI PET for Lung Fibrosis
This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in…
- Conditions
- Interstitial Lung Disease, Idiopathic Interstitial Pneumonias, Drug-Induced Pneumonitis, Hypersensitivity Pneumonitis
- Trial name
- FAPI ILD (NCT05365802)
- Testing
- 68Ga-FAPi-46, Computed Tomography, Positron Emission Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Breast Carcinoma, Fibrosis
Clinical Benefit of Spa Care on Severe Radiation-induced Fibrosis After Postoperative Radiotherapy for Breast Cancer
This study evaluates the dermatological life quality six months after spa cares in patients with severe late toxicity involving the skin and / or soft tissues after postoperative radiotherapy for breast cancer.
- Trial name
- FIBROTHERME (NCT02898376)
- Testing
- skin-oriented spa care, Pentoxifylline, Tocopherol acetate
- Where
- 21 sites in France
- Volunteers
- 142 people
- Sponsor
- Institut de Cancérologie de Lorraine
Fibrosis
Trental & Vitamin E for Radiation-Induced Fibrosis
This study seeks to determine if a combination of Trental and Vitamin E prevents the development of radiation fibrosis in women treated with radiation for the definitive management of their breast cancer.
- Trial name
- NCT00583700
- Testing
- Pentoxifylline, Vitamin E
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Iowa
Lung Cancer, Radiation Fibrosis
Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
The goal of this study is to investigate the efficacy of [68Ga]CBP8 to detect collagen deposition in radiation induced tissue injury.
- Conditions
- Lung Cancer, Radiation Fibrosis, Radiation Induced Lung Injury, Pancreas Cancer
- Trial name
- NCT04485286
- Testing
- [68Ga]CBP8
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Massachusetts General Hospital
Malignant Neoplasm of Breast Stage I
Trial to Compare Radiation Fibrosis With Five Versus Three Fractions
Post meno-pausal women with T1 Breast cancers will be randomized to receive either 600 centiGray (cGy) X 5 over five consecutive days (arm 1) versus 800 cGy X 3 fractions given every other day (arm 2).
- Trial name
- NCT02755896
- Testing
- Arm 1 600 cGY x 5 fractions, Arm 2 800 cGY x 3 fractions
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Weill Medical College of Cornell University
Fibrosis, Radiation Injuries
Trial of Pentoxifylline in Patients With Functional Disability Caused by Radiation-Induced Advanced Regional Fibrosis
After initial assessment of their condition by specified clinical and laboratory parameters, each of the patients will be treated for 8 weeks at the standard pentoxifylline dose (400 mg po TID).
- Trial name
- NCT00001437
- Testing
- pentoxifylline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group
Breast Cancer, Myocardial Fibrosis
Losartan in Prevention of Radiation-Induced Heart Failure
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer.
- Conditions
- Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
- Trial name
- NCT05607017
- Testing
- Losartan, Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital