Clinical trials: Radiation Injury
Radiation Dermatitis
Bacterial Decolonization to Prevent Radiation Dermatitis
The purpose of this study is to determine whether bacterial decolonization of the nares and skin prior to treatment with radiotherapy (RT) for patients with cancers of the head and neck or breast, can prevent high-grade radiation…
- Trial name
- NCT03883828
- Testing
- Chlorhexidine gluconate solution, Mupirocin Ointment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Montefiore Medical Center
Cervical Cancer
Evaluation of Vaginal Dose in Cervical Cancer Patients Treated With Radiotherapy
Cervical cancer is the most common malignant in women with the average five-year overall survival rate as high as 70%. Radiation therapy is the main treatment for cervical cancer.
- Trial name
- NCT03257475
- Testing
- Brachytherapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xi'an Jiaotong University
Lung Cancer, Radiation-Induced Disorder
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy.
- Conditions
- Lung Cancer, Radiation-Induced Disorder, Radiation Pneumonitis, Pulmonary Disease
- Trial name
- ASPECT (NCT04676828)
- Testing
- Single-photon-emission CT scan
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Cervical Cancer, Radiotherapy Side Effect
An Analysis of the Quality of Life and Sexual Quality of Life of Cervical Cancer Radiotherapy Patients
Cervical cancer radiotherapy patients have a decline in quality of life and sexual quality of life
- Conditions
- Cervical Cancer, Radiotherapy Side Effect, Quality of Life
- Trial name
- NCT03885505
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Carpal Tunnel Syndrome (CTS), Wrist
Analysis of Radiographic Indices in Carpal Tunnel Syndrome
The aim of this study was to compare wrist radiographic indices in patients with idiopathic carpal tunnel syndrome (CTS) with normal cases.
- Conditions
- Carpal Tunnel Syndrome (CTS), Wrist, X-Ray, Radiography
- Trial name
- NCT06841809
- Where
- Turkey (Türkiye)
- Volunteers
- 275 people
- Sponsor
- Ankara Training and Research Hospital
Breast Cancer
Myocet Plus Endoxan for Older Patients With Breast Cancer
This study will evaluate the efficacy, safety and effect on quality of life of liposomal-encapsulated doxorubicin in combination with cyclophosphamide as first or second line treatment of older patients (≥ 70 years old) with…
- Trial name
- NCT01120171
- Testing
- Cyclophosphamide, Liposomal-encapsulated doxorubicin
- Where
- 11 sites in Greece
- Volunteers
- 64 people
- Sponsor
- Hellenic Oncology Research Group
Cardiotoxicity
Early Detection of Cardiotoxicity From Systemic and Radiation Therapy in Breast Cancer Patients
To assess the role of myocardial oedema on CMR (T2 mapping) after radiation therapy and cardiotoxic systemic therapy in predicting the incidence of cardiotoxicity, defined as by consensus guidelines* (decline of LVEF ≥10% points…
- Trial name
- CARDIOTOX (NCT04790266)
- Testing
- Cardiac MRI
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Oncology Institute of Southern Switzerland
Prostate Adenocarcinoma
Patients Overexposed for a Prostate Adenocarcinoma
Background: Between 2000 and 2006, 433 patients were overexposed (8% to 10%) during a course of conformal radiotherapy for a prostate adenocarcinoma in Jean MONNET hospital, Epinal, France.
- Trial name
- EPOPA (NCT00773656)
- Testing
- Whole blood sample
- Where
- France
- Volunteers
- 249 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Hypofractionation
HYPofractionated Adjuvant RadioTherapy in 1 Versus 2 Weeks in High-risk Patients With Breast Cancer (HYPART).
We at PGIMER have been practicing hypofractionated radiotherapy in breast cancer patients for the last 4 decades. Our standard doses have been 35Gy/15#/3wks to the chest wall after mastectomy and 40Gy/16#/3wks after breast…
- Conditions
- Breast Cancer, Hypofractionation, Radiotherapy Side Effect
- Trial name
- HYPART (NCT04472845)
- Testing
- 1 week RT, 2 week RT
- Where
- India
- Volunteers
- 1,018 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Breast Cancer, Radiotherapy Side Effect
Ultra-hypofractioNated Adjuvant Radiotherapy ± sImultaneous Integrated Boost for Low-risk Breast Cancer Patients
This is a phase II study to investigate the feasibility of Ultra-hypofractionated radiotherapy with or without simultaneous integrated boost for low risk breast cancer patients who have received breast conservative surgery of…
- Trial name
- UNIQUE (NCT05762900)
- Testing
- Ultra-fractionated radiation therapy
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Radiodermatitis, Breast Neoplasms
Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients
The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
- Conditions
- Radiodermatitis, Breast Neoplasms, Adverse Effect of Radiation Therapy
- Trial name
- NCT02922244
- Testing
- Control, Cucumber cream, Centella cream
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chulabhorn Cancer Center
Oral Mucositis, Quality of Life
Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.
The use of a novel topical mucosa composition (XCM-OM118) comprising 2-(trimethylazaniumyl) acetate; (2R,3R,4S)-pentane-1,2,3,4,5-pentol; Hexadecanoic acid; (9Z, 12Z)-octadeca-9,12-dienoic acid; octadecanoic acid…
- Conditions
- Oral Mucositis, Quality of Life, Mucositis, Pain
- Trial name
- STOPOMP (NCT05635929)
- Testing
- XCM-OM118 Composition comprising olive oil, betaine and xylitol
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Mucosa Innovations, S.L.
Ototoxicity, Unspecified Adult Solid Tumor
Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin
RATIONALE: Alpha-lipoic acid may prevent or lessen hearing loss caused by cisplatin. PURPOSE: This randomized clinical trial is studying the effectiveness of alpha-lipoic acid in preventing hearing loss in cancer patients…
- Trial name
- NCT00477607
- Testing
- alpha-lipoic acid, Audiology, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- US Department of Veterans Affairs
Solid Carcinoma, 5-Fluorouracil Toxicity
Prevention of Chest Pain in Chemo-treated Cancer Patients
This is a prospective, exploratory, randomised clinical trial. Patients with diagnosed cancer that are to be treated with 5-fluorouracil (5-FU) will be randomised into standard oncological treatment or a cardiological assessment…
- Conditions
- Solid Carcinoma, 5-Fluorouracil Toxicity, Cardiotoxicity, Chemotherapeutic Toxicity
- Trial name
- CATCH (NCT03486340)
- Testing
- Cardiologic assessment
- Where
- Denmark
- Volunteers
- 218 people
- Sponsor
- Vejle Hospital
Oral Mucositis Due to Radiation
A Sequential Cohort Study Exploring GELCLAIR in the Management of Oral Mucositis in Patients Receiving Radical Radiation for Head and Neck Cancer
The goal of this clinical trial is to learn if Gelclair lubricant gel can help manage Oral Mucositis (OM) among Oropharyngeal and Oral cavity cancer patients receiving radiation treatment.
- Trial name
- GOMS (NCT06897215)
- Testing
- Hyaluronic acid hydrogel
- Volunteers
- 48 people
- Sponsor
- Nova Scotia Health Authority
Radiodermatitis
Dose-Response Curve: Interventions to Prevent and Treat Radiodermatitis
Dose response curve to define the security and tolerable dose to be used for prevention and treatment of radiodermatitis in patients with breast or head and neck cancer.
- Trial name
- DRCPTR (NCT02249884)
- Testing
- Urea Dose A, Urea Dose B, Urea Dose C
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Brasilia
Taxane, Drug-related Side Effects and Adverse Reactions
Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia
Paclitaxel is chemotherapeutic agent used in many of the most common anti-cancer regimens. Its use is frequently associated with moderate to severe muscle and joint pain that may persist for several days after the treatment.
- Conditions
- Taxane, Drug-related Side Effects and Adverse Reactions, Pain, Breast Cancer
- Trial name
- NCT02024568
- Testing
- Pregabalin
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Assaf-Harofeh Medical Center
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Hyperbaric Oxygen Therapy in Treating Patients With Radiation Necrosis of the Brain
RATIONALE: Hyperbaric oxygen may increase blood flow and decrease swelling in areas of the brain damaged by radiation therapy. Giving hyperbaric oxygen therapy together with dexamethasone may be an effective treatment for…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Radiation Toxicity
- Trial name
- NCT00087815
- Testing
- dexamethasone, hyperbaric oxygen, cognitive assessment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Barrett Cancer Center
Radiation Injury, Breast Cancer
Breast Cancer Lung Late Effects
Through improved early detection and treatment, the number of long term breast cancer survivors continues to increase. There are now 2.8 million breast cancer survivors in the U.S.
- Trial name
- BELLE (NCT02725840)
- Testing
- Proton beam radiation therapy., X-ray based radiation therapy, Computed Tomography (CT) Scan
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Florida
Osteoradionecrosis
Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study
There is currently not sufficient evidence that hyperbaric oxygen (HBO) benefits the surgical removal of necrotic bone in osteoradionecrosis patients.
- Trial name
- NCT00760682
- Testing
- Hyperbaric oxygen
- Where
- 4 sites in Denmark, Sweden and 1 more
- Volunteers
- 114 people
- Sponsor
- Lone Forner
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