Clinical trials: Radiation Injury
Radiosensitivity, Pediatric Cancer
Integrative Molecular Analysis of Individual Radiosensitivity in Pediatric Oncology
Analysis of the individual radiosensitivity in pediatric oncology
- Conditions
- Radiosensitivity, Pediatric Cancer, Radiation Toxicity
- Trial name
- FOCUSO (NCT06033183)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Neolys
Breast Cancer, Radiotherapy Side Effect
Simultaneous Integrated Boost Technique in Breast Cancer Radiotherapy
Adjuvant radiotherapy after breast conserving surgery has been shown to improve both local control and overall survival. Dose escalation of the tumor bed by addition of a boost after whole breast radiotherapy reduces the risk of…
- Trial name
- NCT04535895
- Testing
- Simultaneous integrated boost
- Where
- Austria
- Sponsor
- Medical University of Graz
Breast Neoplasms, Hypothyroidism
A Prospective Study of Hypothyroidism After Radiotherapy for Breast Cancer
This study is to prospectively investigate the incidence of hypothyroidism after postoperative radiotherapy and identify risk factors for development of hypothyroidism.
- Conditions
- Breast Neoplasms, Hypothyroidism, Radiation Toxicity
- Trial name
- NCT04528225
- Where
- China
- Volunteers
- 729 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung), Drug-Related Side Effects and Adverse Reactions (MeSH Term)
Cancer Therapy-Related Cardiac Dysfunction Associated With EGFR-TKIs in Advanced EGFR-mutant Non-small Cell Lung Cancer
This study investigated the incidence of cardiac dysfunction in patients with advanced or recurrent epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer treated with EGFR- tyrosine kinase inhibitors.
- Conditions
- Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung), Drug-Related Side Effects and Adverse Reactions (MeSH Term), Egfr Tyrosine Kinase Inhibitor, Cardiotoxicity
- Trial name
- NCT07267247
- Testing
- EGFR-TKI, EGFR tyrosine kinase inhibitor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taichung Veterans General Hospital
Radiation Pneumonitis
Risk Factors of Radiation Pneumonitis
A prospective observational study to evaluate clinical, dosimetrical, functional, and biological factors in predicting radiation pneumonitis.
- Trial name
- NCT00155909
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- National Taiwan University Hospital
Radiation Pneumonitis, Endostatin
Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis
To verify the efficacy and safety of endostatin in the treatment of SRILI（symptomatic radiation-induced lung injury） and fibrosis.
- Trial name
- NCT03796364
- Testing
- Endostar, standard SRILI treatment
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xinqiao Hospital of Chongqing
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer, Radiotherapy Side Effect
Safety of Ultra-hypofractionated Whole Breast Irradiation After Breast-conserving Surgery
SAFE-FORWARD is an observational prospective cohort study. Patient population included both invasive and ductal carcinoma in situ (DCIS) breast cancer receiving ultra-hypofractionated whole breast irradiation (26 Gy in 5…
- Trial name
- SAFE-FORWARD (NCT04842409)
- Testing
- Whole breast irradiation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Rectal Cancer, Total Neoadjuvant Treatment
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
This study hypothesizes that approximately 50% of rectal cancer patients can preserve their rectum using a watch-and-wait strategy if they achieve a complete or near-complete clinical response to total neoadjuvant therapy (TNT).
- Conditions
- Rectal Cancer, Total Neoadjuvant Treatment, Neoadjuvant Therapy, Radiotherapy
- Trial name
- NCT06758830
- Testing
- Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Cardiac Toxicity, Cancer
Cardiovascular Health in Adult Patients With Cancer Exposed to Cardiotoxic Therapies
The goal of this observational study is to evaluate the cardiovascular health and prognosis of adult patients with cancer, treated with cardiotoxic therapies.
- Trial name
- CV_CANCER (NCT06664528)
- Testing
- ECHOCARDIOGRAPHY, ELECTROCARDIOGRAPHY (ECG), LABORATORY TESTS
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Elderly, Cancer
Improving Quality of Life and Function for Older Cancer Patients Receiving Radiotherapy
This study is a first part of a larger project aiming at improving the following outcomes in older cancer patients receiving external beam radiation therapy (EBRT): quality of life, functioning and need for professional help…
- Conditions
- Elderly, Cancer, Radiotherapy Side Effect
- Trial name
- NCT03071640
- Where
- Norway
- Volunteers
- 302 people
- Sponsor
- Sykehuset Innlandet HF
To Evaluate the Safety of Taurine in Preventing Acute Radiation Skin Injury Induced by Adjuvant Radiotherapy in Breast Cancer Patients
Phase I-II Clinical Study of Taurine for External Use in the Prevention and Treatment of Acute Radiation Skin Injury
Acute radiation skin injury is the most common side effect of radiation therapy in patients with chest tumors, which can be manifested as erythema, dry peeling, wet peeling, and severe ulcers.
- Trial name
- NCT06847555
- Testing
- Radiation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shandong Cancer Hospital and Institute
Shoulder Fractures
X-Ray Follow-up in Proximal Humeral Fractures Conservatively Treated
Randomly assign patients with fractures of the proximal humerus to conservative treatment to a group in which a control radiological study will be carried out after a week of evolution of the fracture and to another group in…
- Trial name
- NCT04651543
- Testing
- X-Ray
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital del Mar
Hearing Loss, Ototoxicity
Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity?
Aspirin (ASA) has been shown, in an animal model, to attenuate the ototoxic properties of cisplatin. The researchers plan to investigate this in patients undergoing cisplatin chemotherapy.
- Trial name
- NCT00578760
- Testing
- aspirin
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- University Health Network, Toronto
Radiodermatitis
Preventive Effect of Boron-based Gel on Radiation Dermatitis
Preventive Effect of Boron-based Gel on Radiation Dermatitis
- Trial name
- boron_gel (NCT04239560)
- Testing
- Boron-based Gel (Fibore)
- Where
- Iran
- Volunteers
- 257 people
- Sponsor
- Tabriz University of Medical Sciences
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Cardiotoxicity, Osteosarcoma
Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR
using a contrast-enhanced (CE) cardiac magnetic resonance imaging(CMR) which included the measurement of T1 mapping, T2 mapping, T2* mapping and late gadolinium enhancement(LGE) sequences, as well as LVEF and extracellular…
- Conditions
- Cardiotoxicity, Osteosarcoma, Myocardial Injury, Chemotherapy Induced Systolic Dysfunction
- Trial name
- NCT04461223
- Testing
- contrast-enhanced cardiac magnetic resonance imaging(MAGNETOM Aera 1.5T)
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer
Circulating MicroRNA as Biomarker of Cardiotoxicity in Breast Cancer
In the proposed project the investigators will asses whether changes in expression of selected circulating microRNAs in serum could comprise a sensitive and specific biomarker of cardiotoxicity in cancer patients treated with…
- Trial name
- NCT02065908
- Where
- 3 sites in Poland
- Volunteers
- 128 people
- Sponsor
- West Pomeranian Cancer Center
Radiation Induced Dermatitis
Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer
The standard treatment for early-stage breast cancer is breast-conserving surgery followed by adjuvant radiation therapy to the whole breast.
- Trial name
- NCT01513278
- Testing
- APN201
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Apeiron Biologics
Cancer
Detection of Chemotherapy Induced Cardiotoxicity
To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).
- Trial name
- NCT00636844
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- George Washington University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.